High sensitive detection in tumor extracts with SiNW-FET in-air biosensors

Puppo, Francesca; Doucey, Marie‐Agnès; Delaloye, Jean-François; Moh, T. S. Y.; Pandraud, G.; Sarro, P.M.; Micheli, Giovanni De; Carrara, Sandro

doi:10.1109/icsens.2014.6985137

Cited by 9 publications

(11 citation statements)

References 11 publications

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“…A SiNW-based device was previously reported for the detection of pathogenic factors at very low concentrations (fM) in phosphate buffered saline (PBS). In this device, the SiNW senses rabbit antigen molecules in the presence of a 100 000 mass excess of the non-specific tumor protein, indicating that the biosensor is excessively resistant to noise (Puppo et al, 2014).…”

Section: Protein Sensors Regonda Et Al Demonstrated a New Fet-biosementioning

confidence: 99%

Current trends in nanomaterial embedded field effect transistor-based biosensor

Nehra

Singh

2015

Biosensors and Bioelectronics

116

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Section: Protein Sensors Regonda Et Al Demonstrated a New Fet-biosementioning

confidence: 99%

Current trends in nanomaterial embedded field effect transistor-based biosensor

Nehra

Singh

2015

Biosensors and Bioelectronics

116

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“…Although nanowire-based detection of protein cancer markers has clearly evolved from the measurement of purified markers spiked into buffer to the measurement of markers spiked into healthy human serum, a very limited number of studies have quantified these markers in cancer patient blood-derived specimens [27,28]. Along the same lines, to date only two studies have reported the detection of a spiked antigen in cancer patient tissues using antibody-based FET [29,30] or memristor sensors [31]. In these Box 2.…”

Section: Protein Cancer Markersmentioning

confidence: 99%

“…studies, a spiked rabbit antigen was detected in the fM range in the presence of a 100 000-fold molar excess of non-specific human proteins [29][30][31]. The main limitations of nanowire sensors in detecting cancer markers in clinical specimens are the presence of salts that decrease the Debye length, the need for individual sensor calibration, and the multiplex capabilities of nanowire sensors which are so far limited to a maximum of three analytes.…”

Section: Protein Cancer Markersmentioning

confidence: 99%

Nanowire Sensors in Cancer

Doucey

Carrara

2019

Trends in Biotechnology

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In 2006, the group of Dr C.M. Lieber pioneered the field of nanowire sensors by fabricating devices for the ultra-sensitive label-free detection of biological macromolecules. Since then, nanowire sensors have demonstrated their ability to detect cancer-associated analytes in peripheral blood, tumor tissue, and the exhaled breath of cancer patients. These innovative developments have marked a new era with unprecedented detection performance, capable of addressing crucial needs such as cancer diagnosis and monitoring disease progression and patient response to therapy. The ability of nanowire sensors to identify molecular features of patient tumor represents a first step toward precision medicine, and their integration into portable devices has the potential to revolutionize cancer diagnosis and patient monitoring.

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“…Protein detection and investigation in various biological samples such as blood, serum, urine, and saliva is the center to disease diagnosis and treatment. In another report, Puppo et al (2014) used single NW-based FET to detected bioanalytes in exogenously added rabbit antigen (5-200 fM) in a human breast tumor extract (a much more complex environment). They fabricated Si NGs-FETs with highly uniform performance using a complementary metal-oxide semiconductor (CMOS) process on low pdoped silicon-on-insulator wafers (Fig.…”

Section: Silicon Nws-based Fet Biosensormentioning

confidence: 99%

Recent advances in nanowires-based field-effect transistors for biological sensor applications

Ahmad

Mahmoudi

Ahn

et al. 2018

Biosensors and Bioelectronics

136

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Nanowires (NWs)-based field-effect transistors (FETs) have attracted considerable interest to develop innovative biosensors using NWs of different materials (i.e. semiconductors, polymers, etc.). NWs-based FETs provide significant advantages over the other bulk or non-NWs nanomaterials-based FETs. As the building blocks for FET-based biosensors, one-dimensional NWs offer excellent surface-to-volume ratio and are more suitable and sensitive for sensing applications. During the past decade, FET-based biosensors are smartly designed and used due to their great specificity, sensitivity, and high selectivity. Additionally, they have the advantage of low weight, low cost of mass production, small size and compatible with commercial planar processes for large-scale circuitry. In this respect, we summarize the recent advances of NWs-based FET biosensors for different biomolecule detection i.e. glucose, cholesterol, uric acid, urea, hormone, proteins, nucleotide, biomarkers, etc. A comparative sensing performance, present challenges, and future prospects of NWs-based FET biosensors are discussed in detail.

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High sensitive detection in tumor extracts with SiNW-FET in-air biosensors

Cited by 9 publications

References 11 publications

Current trends in nanomaterial embedded field effect transistor-based biosensor

Current trends in nanomaterial embedded field effect transistor-based biosensor

Nanowire Sensors in Cancer

Recent advances in nanowires-based field-effect transistors for biological sensor applications

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