High-sensitive quantitative phase imaging with averaged spectral domain phase microscopy

Yan, Yangzhi; Ding, Zhihua; Wang, Chuan; Shen, Yi

doi:10.1016/j.optcom.2013.04.015

Cited by 5 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, polarization-sensitive OCT has the potential of high spatial resolution, which can display detailed structural information. In contrast, the phase-sensitive OCT is based on the high sensitivity to the phase difference between the sample arm and the reference arm [29], avoiding common-mode noise [30]. It is a powerful and potential technology with high sensitivity (26,27), which can be used to measure the sample's motion.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

et al. 2021

View full text Add to dashboard Cite

Optical coherence tomography (OCT) has become a novel approach to noninvasive imaging in the past three decades, bringing a significant potential to biological research and medical biopsy in situ, particularly in three-dimensional (3D) in vivo conditions. Specifically, OCT systems using broad bandwidth sources, mainly centered at near-infrared-II, allow significantly higher imaging depth, as well as maintain a high-resolution and better signal-to-noise ratio than the traditional microscope, which avoids the scattering blur and thus obtains more details from delicate biological structures not just limited to the surface. Furthermore, OCT systems combined the spectrometer with novel light sources, such as multiplexed superluminescent diodes or ultra-broadband supercontinuum laser sources, to obtain sub-micron resolution imaging with high-speed achieve widespread clinical applications. Besides improving OCT performance, the functional extensions of OCT with other designs and instrumentations, taking polarization state or birefringence into account, have further improved OCT properties and functions. We summarized the conventional principle of OCT systems, including time-domain OCT, Fourier-domain OCT, and several typical OCT extensions, compared their different components and properties, and analyzed factors that affect OCT performance. We also reviewed current applications of OCT in the biomedical field, especially in hearing science, discussed existing limitations and challenges, and looked forward to future development, which may provide a guideline for those with 3D in vivo imaging desires.

show abstract

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

Constrained polynomial fit-based k-domain interpolation in swept-source optical coherence tomography

Han

Qiu

et al. 2021

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

We propose a [Formula: see text]-domain spline interpolation method with constrained polynomial fit based on spectral phase in swept-source optical coherence tomography (SS-OCT). A Mach–Zehnder interferometer (MZI) unit is connected to the swept-source of the SS-OCT system to generate calibration signal in sync with the fetching of interference spectra. The spectral phase of the calibration signal is extracted by Hilbert transformation. The fitted phase–time relationship is obtained by polynomial fitting with the constraint of passing through the central spectral phase. The fitting curve is then adopted for [Formula: see text]-domain uniform interpolation based on evenly spaced phase. In comparison with conventional [Formula: see text]-domain spline interpolation, the proposed method leads to improved axial resolution and peak response of the axial point spread function (PSF) of the SS-OCT system. Enhanced performance resulting from the proposed method is further verified by OCT imaging of a home-constructed microspheres-agar sample and a fresh lemon. Besides SS-OCT, the proposed method is believed to be applicable to spectral domain OCT as well.

show abstract

High-sensitive and broad-dynamic-range quantitative phase imaging with spectral domain phase microscopy

et al. 2013

View full text Add to dashboard Cite

Spectral domain phase microscopy for high-sensitive and broad-dynamic-range quantitative phase imaging is presented. The phase retrieval is realized in the depth domain to maintain a high sensitivity, while the phase information obtained in the spectral domain is exploited to extend the dynamic range of optical path difference. Sensitivity advantage of phase retrieved in the depth domain over that in the spectral domain is thoroughly investigated. The performance of the proposed depth domain phase based approach is illustrated by phase imaging of a resolution target and an onion skin.

show abstract

High-sensitive quantitative phase imaging with averaged spectral domain phase microscopy

Cited by 5 publications

References 12 publications

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

Optical Coherence Tomography for Three-Dimensional Imaging in the Biomedical Field: A Review

Constrained polynomial fit-based k-domain interpolation in swept-source optical coherence tomography

High-sensitive and broad-dynamic-range quantitative phase imaging with spectral domain phase microscopy

Contact Info

Product

Resources

About