High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

Abstract

Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P < 0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P < 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P < 0.001), logarithmically transformed creatinine (log-creatinine; P < 0.001), female DM patients (P < 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P = 0.013) were positively correlated, while albumin (P = 0.004) and glomerular filtration rate (GFR; P = 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.

Adipocyte Fatty Acid‐Binding Protein as a Novel Marker of Psoriasis and Clinical Response to Acitretin

“…These differences may be due to some methodological nuances or other modifying factors within the studied groups. There were no statistical differences in terms of sex in both of our studies, although a significantly elevated level of adipocyte-type FABP was reported in females suffering from chronic obstructive pulmonary disease (COPD) (Zhang, 2016) and type 2 diabetes (Li, 2016).…”

“…Several studies on the systemic pharmacological influence on FABP4 were conducted. Li, did not reveal any associations between selected drugs such statins, fibrate, or antidiabetic drugs inter alia thiazolidinedione and adipocyte‐type FABP in diabetics. Contrarily, Cabré et al () noted that TZD increased plasma and mRNA of FABP4 along with PPAR‐γ activation in diabetic patients.…”

“…Nonetheless, the lack of relation with metabolic indices does not exclude the potential role of FABP4 as an indicator of comorbidities in psoriatics. Furthermore, statistical correlations of FABP4 with HDL‐cholesterol and LDL‐cholesterol, TAG, BMI, or CRP have been shown in other diseases (Kralisch, ; Li, ; Xu, ). Contrarily, Zhang () did not prove a positive relation with BMI in patients with COPD.…”

High Levels of Serum Adipocyte Fatty Acid-binding Protein Predict Cardiovascular Events in Coronary Artery Disease Patients

“…It plays an important role in lipid oxidation and insulin sensitivity regulation. Several studies in mice report that A-FABP deficiency protects against hyperglycemia, insulin resistance, and dyslipidemia 16 , and clinical studies show that serum A-FABP level is positively associated with the occurrence of metabolic syndrome 3 , 10 , 13 , 17 . Both waist circumference and TG level are important risk factors for metabolic syndrome.…”

Study on the correlation between adipocyte fatty‐acid binding protein, glucolipid metabolism, and pre‐eclampsia

“…A‐FABP is an adipokine that participates in lipid metabolism and its expression has been strongly linked with diabetes and metabolic syndrome . Typically, insulin resistance is actually an adaptive response during pregnancy for maintaining blood glucose within a certain range, which is conducive to satisfying fetal growth and maternal energy metabolism needs.…”