High serum uric acid concentration predicts poor survival in patients with breast cancer

Yue, Caifeng; Feng, Pinning; Yao, Zhenrong; Yu, Xinmin; Lin, Wenbin; Qian, Yuanmin; Guo, Yun-Miao; Li, Laisheng; Liu, Min

doi:10.1016/j.cca.2017.08.027

Cited by 29 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with the highest quartile of uric acid increased their overall risk of cancer death by 27% compared with the lowest quartile group. Yue et al performed a study that included 443 female breast cancer patients to investigate the association between SUA and the risk of breast cancer, and after a 56 months of follow‐up, a poor OS was observed in patients with relative higher SUA concentration, which confirmed a significant association of increased uric acid concentration with poor clinical outcome in breast cancer patients. Another study conducted by Panis et al showed that SUA concentration in advanced breast cancer (TNM stages IIIc and IV) was significantly higher than that in early stages of breast cancer patients (TNM stages I and II) and control group.…”

Section: Discussionmentioning

confidence: 90%

“…Meanwhile, the serum uric acid concentration was positively correlated with the advanced stages (TNM stages IIIc and IV) in breast cancer compared with early stages (TNM stages I and II) . Moreover, high SUA concentration predicted a poor survival in breast cancer patients . Therefore, we hypothesized that there may be a relationship between gout‐related single nucleotide polymorphisms (SNPs; rs2188380) and BC risk.…”

Section: Introductionmentioning

confidence: 99%

“…10 Moreover, high SUA concentration predicted a poor survival in breast cancer patients. 11 Therefore, we hypothesized that there may be a relationship between gout-related single nucleotide polymorphisms (SNPs; rs2188380) and BC risk. In order to verify this hypothesis, our study was conducted to assess the association between rs2188380 and BC risk as well as the clinicopathological characteristics comprehensively among Guangxi population in the southwest China.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Lin

Liao

Chen

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

BackgroundPrevious studies have revealed that the single nucleotide polymorphism (SNP) rs2188380 was identified as a novel locus of gout. Interestingly, gout resulting from high serum uric acid (SUA) was also identified to be associated with the risk of breast cancer (BC). We hypothesized that maybe there was a relationship between rs2188380 and the risk of BC. Therefore, our study was conducted to investigate whether this novel gout‐related SNP (rs2188380) was associated with BC risk as well as the clinical and pathological characteristics in the southwest Chinese population.Materials and methodsWe performed a case‐control study including 104 breast cancer patients and 112 healthy controls to investigate whether rs2188380 is associated with BC risk in the southwest Chinese population. The genotyping was performed by the SNP scan method. General characteristics and clinicopathological characteristics of tumors were also included in the analysis. The statistical evaluations were performed using the Student t test, the chi‐square test or Fisher's exact test, and unconditional logistic regression analysis.ResultsThe C/C genotype of rs2188380 might be related to BC risk to some extent compared with G/G genotype (OR = 9.241, 95% CI = 1.122‐76.101, P = 0.039). Furthermore, after adjusting the age, the association still existed (OR = 8.788, 95% CI = 1.063‐72.636, P = 0.044). However, no significant association was observed between rs2188380 and the clinicopathological characteristics of BC.ConclusionsOur study primarily indicated that rs2188380 might have a potential association with BC risk to some extent. With a limited sample size and statistical power, further studies based on larger populations are needed to confirm the association.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Lin

Liao

Chen

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…However, there is a growing consensus that high SUA levels increase the risk of cancer. When intracellular SUA increases, in ammatory stress is induced by affecting the activation of cyclooxygenase-2 and production of reactive oxygen species, while extracellular SUA level increase stimulates a variety of transcription factors and promotes cancer cell survival, proliferation, and migration [7,9,21]. SUA also enters adipocytes through uric acid-speci c transporter and down-regulates expression of xanthine dehydrogenase or xanthine oxidoreductase, thus increasing expression of matrix metalloproteinases, cyclooxygenase-2, epithelial-mesenchymal transition genes, and transforming growth factor-β to encourage stronger invasiveness and metastatic ability in liver, breast, and other cancer cells [5,17,18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Preoperative Serum Uric Acid-to-Lymphocyte Ratio in Hepatocellular Carcinoma Patients Undergoing Postoperative Transarterial Chemoembolization: A Propensity Score-Matching Study

Hu¹,

Liu²,

Tang³

2020

Preprint

View full text Add to dashboard Cite

BackgroundHepatocellular carcinoma (HCC) accounts for 85%–90% of primary liver cancers and is the seventh most common cancer worldwide. The purpose of this study is to determine an innovative and effective clinical index for prognosis prediction in HCC patients. MethodsA total of 132 patients with HCC were included in this research. A cohort of 72 cases was obtained through propensity score-matching. Patients were divided into high- and low-level groups based on the ratio of preoperative uric acid levels to lymphocytes. The differences in clinical characteristics and survival indicators were compared between the two groups.ResultsThere was a statistical difference between uric acid-to-lymphocyte ratio (ULR) level and tumor size (P < 0.01). Multivariate analysis showed that ULR (P = 0.03) and tumor size (P = 0.03) were independent risk factors for overall survival (OS). ULR (P < 0.04) and diabetes (P = 0.04) were independent risk factors for progression-free survival (PFS) in HCC patients. Further survival analysis of the entire cohort and propensity score-matching cohort showed that the OS and PFS in the high-level ULR group were significantly shorter than those in the low-level ULR group (log-rank P < 0.001). Conclusion This study demonstrated that ULR is a marker of poor prognosis in postoperative HCC patients, while high ULR levels predicted shorter OS and PFS.

show abstract

“…High cellular turnover and the occurrence of tumour cell lysis are classically considered as an explanation for the increased UA levels in cancer patients. High serum UA levels are associated with aggressiveness in tumours originating from the colon and rectum [ 9 , 10 ], pancreas [ 11 ], breast [ 12 ] and the upper aero-digestive tract [ 13 , 14 ]. However, an increase in serum UA levels can also occur in the early stages of tumorigenesis [ 15–17 ].…”

Section: Introductionmentioning

confidence: 99%

A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates

Saidak

Louandre²,

Dahmani³

et al. 2018

Bioscience Reports

View full text Add to dashboard Cite

Uric acid (UA) is the end product of the catabolism of purines, and its serum levels are commonly increased in cancer patients. We aimed to explore the transcriptional regulation of tumour uricogenesis in human tumours, and relate uricogenesis with tumour pathological and pharmacological findings. Using data from The Cancer Genome Atlas (TCGA), we analysed the expression levels of xanthine dehydrogenase (XDH) and adenine phosphoribosyltransferase (APRT), two key enzymes in UA production and the purine salvage pathway, respectively. We found large differences between tumour types and individual tumours in their expression of XDH and APRT. Variations in locus-specific DNA methylation and gene copy number correlated with the expression levels of XDH and APRT in human tumours respectively. We explored the consequences of this differential regulation of uricogenesis. Tumours with high levels of XDH mRNA were characterised by higher expression of several genes encoding pro-inflammatory and immune cytokines, and increased levels of tumour infiltration with immune cells. Finally, we studied cancer drug sensitivity using data from the National Cancer Institute-60 (NCI-60) database. A specific correlation was found between the expression levels of APRT and cell sensitivity to the chemotherapeutic agent 5-fluorouracil (5-FU). Our findings underline the existence of great differences in uricogenesis between different types of human tumours. The study of uricogenesis offers promising perspectives for the identification of clinically relevant molecular biomarkers and for tumour stratification in the therapeutic context.

show abstract

High serum uric acid concentration predicts poor survival in patients with breast cancer

Cited by 29 publications

References 30 publications

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Prognostic Significance of Preoperative Serum Uric Acid-to-Lymphocyte Ratio in Hepatocellular Carcinoma Patients Undergoing Postoperative Transarterial Chemoembolization: A Propensity Score-Matching Study

A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates

Contact Info

Product

Resources

About