2001
DOI: 10.1080/028418501127346567
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High signal intensity of the posterior pituitary gland on T1-weighted MR images: Correlation with plasma vasopressin concentration to water deprivation

Abstract: There was a negative, linear correlation between the signal intensity ratio of the posterior pituitary gland on T1-weighted MR images and plasma vasopressin concentration to water deprivation. The results support that the high signal intensity of the posterior pituitary gland on T1-weighted MR images is attributed to the normal content of vasopressin-neurosecretory granules.

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Cited by 7 publications
(3 citation statements)
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“…This observation has been made previously 33,34 in a small number of adults, but is not widely appreciated in paediatrics. Experiments in water‐deprived rabbits showed a direct correlation between the signal intensity of the bright spot and vasopressin concentration in the posterior pituitary, 35 and a negative correlation between the signal intensity and plasma vasopressin concentration, 36 suggesting that the hyperintensity on MRI is caused by vasopressin in neurosecretory granules. Depletion or absence of this stored vasopressin results in loss of the bright spot, which explains why the posterior pituitary bright spot disappears in states of AVP hypersecretion, such as untreated XNDI.…”
Section: Discussionmentioning
confidence: 99%
“…This observation has been made previously 33,34 in a small number of adults, but is not widely appreciated in paediatrics. Experiments in water‐deprived rabbits showed a direct correlation between the signal intensity of the bright spot and vasopressin concentration in the posterior pituitary, 35 and a negative correlation between the signal intensity and plasma vasopressin concentration, 36 suggesting that the hyperintensity on MRI is caused by vasopressin in neurosecretory granules. Depletion or absence of this stored vasopressin results in loss of the bright spot, which explains why the posterior pituitary bright spot disappears in states of AVP hypersecretion, such as untreated XNDI.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, the PBS, first attributed to the presence of fat deposits (Chen and Kucharczyk 1989;Nishimura et al 1986), is now thought to reflect the levels of mature ADH levels (Côté et al 2014;Fujisawa et al 1987). Its intensity thus varies with hydration state, as shown experimentally in animals (Lee et al 2001). It also varies with gender (Yamamoto et al 2013).…”
Section: Accounting For the Pbsmentioning
confidence: 97%
“…Il a une forme généra-lement ovalaire ou en « croissant de lune », moins souvent arrondie. Après avoir longtemps fait l'objet de débats passionnés, il est maintenant admis que l'hypersignal en pondération T1 dans la posthypophyse est directement lié à la concentration en ADH stockée [2][3][4] et plus précisément aux granules neurosécrétoires contenant l'ADH. Il s'agit d'un reflet direct du bon fonctionnement de la neurohypophyse.…”
Section: Posthypophyseunclassified