Imagerie par résonance magnétique nucléaire de la neurohypohyse

Antoine, V.; Schmitt, Emmanuelle; Klein, Marc; Bracard, Serge

doi:10.1016/j.ando.2008.02.026

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…In the diagnosis of pituitary tumors, a pathological diagnosis remains the gold standard, sometimes by means of B-mode ultrasound, computed tomography and other imaging examinations, as well as nasal endoscopic and other methods used to judge the distance of the invasion (15,16). However, these methods are difficult as a substitute for pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients

Sun

Fang

et al. 2017

Oncology Letters

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The aim of the study was to investigate the expression and clinical significance of early growth response protein 1 (EGR-1) and phosphatase and tensin homolog (PTEN) in the pituitary tumors of elderly patients. From January 2014 to December 2015, we collected 25 patient cases with non-invasive pituitary tumors, 10 cases with invasive pituitary tumors and 35 cases with healthy pituitary tissues (the healthy control group). Immunohistochemical staining was used to detect the expression of EGR-1 and PTEN, and analyze specific differences. The expression of EGR-1 and PTEN in patients with invasive and non-invasive pituitary tumors increased significantly, when compared with the healthy control group, and the difference was statistically significant (p<0.05). In patients with invasive tumors, EGR-1 levels were higher than levels in patients with non-invasive tumors. The difference was statistically significant (p<0.05). PTEN levels in patients with invasive tumors were significantly lower than levels in patients with non-invasive tumors. The difference was statistically significant (p<0.05). In conclusion, EGR-1 and PTEN levels in patients with pituitary tumors were significantly higher. In addition, EGR-1 levels were higher in patients with invasive pituitary tumors, while PTEN levels were lower. The combination of increases in both levels highlights an important role in the evaluation and prognosis of elderly patients with pituitary tumors.

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Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients

Sun

Fang

et al. 2017

Oncology Letters

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“…Le DIC apparait lorsque 85% des cellules neurosécrétrices sont détruites. En imagerie cela se traduit par une disparition de l'hyper signal spontané de la post hypophyse en pondération T1 [ 18 , 19 ]. D'autres anomalies à l'IRM, sans être spécifiques, permettent en plus d'orienter vers une étiologie du DIC, notamment tumorale et infiltrative.…”

Section: Discussionunclassified

“…Le craniopharyngiome est parmi les tumeurs les plus pourvoyeuses de DIC en raison d'un développement suprasellaire. Cependant, le DIC est rarement le signe révélateur [ 18 ]. Les adénomes hypophysaires se compliquent d'un DIC en cas d'apoplexie ou de développement suprasellaire [ 20 ].…”

Section: Discussionunclassified

Diagnostic étiologique du diabète insipide central: à propos de 41 cas

Chaker¹,

Chihaoui²,

Yazidi³

et al. 2016

Pan Afr Med J

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La survenue d'un syndrome polyuro-polydipsiqueavec des urines hypotoniques nécessite une stratégie diagnostique rigoureuse. Le but de cette étude était d’étudier les modalités de diagnostic du diabète insipide central. A travers une étude rétrospective de 41 cas de diabète insipide central(DIC) colligés au service d'Endocrinologie à l'hôpital de la Rabta de Tunis, allant de l'année 1990 à l'an 2013, nous avons relevé les circonstances de découverte du DIC, les anomalies du bilan anté-hypophysaire etde l'imagerie hypophysaire. Le DIC était post opératoire chez 20 patients. La diurèse moyenne de 24 heures était significativement plus élevée chez les patients ayant un DIC en dehors d'un contexte chirurgical. L’épreuve de restriction hydrique était concluante chez tous les patients qui en ont bénéficié. En dehors d'un contexte neurochirurgical, les causes infiltratives étaient retrouvées chez 6 patientset les causes tumorales chez 6 patients. Le DIC était associé à une selle turcique vide dans 1 cas et idiopathique chez 3 malades. L'imagerie par résonnance magnétique hypothalamo-hypophysaire et le bilan anté-hypophysaire sont systématiques en dehors d'un contexte de chirurgie hypophysaire et d'une polydipsie primaire évidente.

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“…These dimensions are approximately 20% longer than our findings; this may be explained by the fact that the neurohypophysis is an anatomical structure that is larger than the region dense in vasopressin granules that is seen as a hyperintense signal on T1-weighed MRI. 1 In a study of 60 normal subjects (30 men and 30 women), the dimensions of the PBS on T1-weighted and proton density MRI were found to be 4.1 ± 1.6 mm for men and 5.3 ± 1.0 mm for women along the craniocaudal axis and 3.1 ± 0.9 mm (men) and 3.6 ± 0.8 mm (women) along the anteroposterior axis. 8 Our finding of an average long-axis dimension of 4.8 mm seems to be in agreement with these authors' conclusions; we also observed a trend toward larger PBSs in women along the long axis, although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon, often referred to as the pituitary bright spot (PBS), is thought to result from the T1-shortening effect of stored vasopressin in the posterior lobe of the pituitary 1,12 and is observed in 100% of children 15,17 and in 52% to 100% of adults 5,6,8,19,22 without pituitary disease. The PBS may be absent in up to 48% of normal subjects, more often in older patients.…”

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confidence: 99%

Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging

Côté¹,

Salzman

Sorour³

et al. 2014

JNS

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A n area of T1 hyperintensity is normally observed in the posterior part of the sella turcica on MR images of the brain. This phenomenon, often referred to as the pituitary bright spot (PBS), is thought to result from the T1-shortening effect of stored vasopressin in the posterior lobe of the pituitary 1,12 and is observed in 100% of children 15,17 and in 52% to 100% of adults 5,6,8,19,22 without pituitary disease. The PBS may be absent in up to 48% of normal subjects, more often in older patients.5,23 Individual variations in the appearance of the PBS have been observed. Physiological conditions such as very young age, pregnancy, or lactation may result in an enlarged PBS. 2An abnormal PBS can also be seen in various pathological processes. Central diabetes insipidus (DI) results from low blood levels of vasopressin and may be primary or secondary to a number of causes. In primary central DI, the PBS has been found to be absent in 25% to 100% of cases. 12,15,17 Secondary central DI is a feature of Langerhans cell histiocytosis, germinoma, teratoma, craniopharyngioma, idiopathic giant cell granulomatous hypophysitis, and Wolfram syndrome. When DI was a presenting symptom of one of these conditions, the PBS was always absent. 7,9,12,15,17,18 In conditions in which the posterior pituitary is depleted of its vasopressin granules, the hyperintense T1 signal can also be lost. An absent PBS was observed in 32% of patients with uncontrolled diabetes mellitus 11 and in a patient with severe anorexia nervosa. 21Finally, when the pituitary stalk is interrupted, the vasopressin synthesized in the hypothalamus does not reach the posterior pituitary. The absence of a normal PBS in these cases is often accompanied by an ectopic bright spot due to the storage of vasopressin granules in another anatomical location. A patient with pituitary dwarfism was found to have an absent PBS with an ectopic bright spot. 24Acquired section of the pituitary stalk of traumatic or surgical origin has also been found to result in an absent PBS and ectopic bright spot. Object. The normal pituitary bright spot seen on unenhanced T1-weighted MRI is thought to result from the T1-shortening effect of the vasopressin stored in the posterior pituitary. Individual variations in its size may be difficult to differentiate from pathological conditions resulting in either absence of the pituitary bright spot or in T1-hyperintense lesions of the sella. The objective of this paper was to define a range of normal dimensions of the pituitary bright spot and to illustrate some of the most commonly encountered pathologies that result in absence or enlargement of the pituitary bright spot.Methods. The authors selected normal pituitary MRI studies from 106 patients with no pituitary abnormality. The size of each pituitary bright spot was measured in the longest axis and in the dimension perpendicular to this axis to describe the typical dimensions. The authors also present cases of patients with pituitary abnormalities to highlight the differences and potential ov...

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Imagerie par résonance magnétique nucléaire de la neurohypohyse

Cited by 5 publications

References 17 publications

Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients

Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients

Diagnostic étiologique du diabète insipide central: à propos de 41 cas

Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging

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