High strength brushite bioceramics obtained by selective regulation of crystal growth with chiral biomolecules

Moussa, Hanan; Jiang, Wenge; Alsheghri, Ammar; Mansour, Alaa; hadad, Amir A. El; Pan, Haihua; Tang, Ruikang; Song, Jun; Vargas, Javier; McKee, Marc D.; Tamimi, Faleh

doi:10.1016/j.actbio.2020.01.047

Cited by 26 publications

(50 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 17 This can lead to particle release causing inflammation and deep vein thrombosis in extreme cases. 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

“… 33 − 36 Recent studies suggest that matrix proteins composed of chiral l -amino acids play an important mineral modulatory role and control mineral crystal nucleation, growth, and morphology of bioceramics through chiral recognition. 37 , 38 It is suggested that α-hydroxy carboxyl acid groups recognize the [101] dynamic step of brushite crystal growth, 18 , 38 allowing compounds such as l -(+)-tartaric acid ( l -(+)-Tar), already used in the pharmaceutical industry, to have a similar mineralization modulatory role, 18 , 37 , 38 which enhances the mechanical properties of bioceramics. 18 …”

Section: Introductionmentioning

confidence: 99%

“…However, l -(+)-Tar interacts strongly with the dynamic step [101] ({020} crystal plane) and limits brushite crystal size. 18 According to computer simulations, tartaric acid has three interaction sides with brushite: a carboxyl group of the tartaric acid interacts with calcium (hydrogen bond) and HPO 4 (hydrogen bond). A hydroxyl group of the tartaric acid forms another hydrogen bond with HPO 4.…”

Section: Introductionmentioning

confidence: 99%

“…A hydroxyl group of the tartaric acid forms another hydrogen bond with HPO 4. 18 The main difference between l -(+)- and d -(−)-Tar is that the hydroxyl group that interacts with brushite is different. In the former, the hydroxyl group is adjacent to the carboxyl group.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, l -(+)-Tar does and inhibits mineral crystal growth. 18 , 39 The theory behind this process is described in Figure 1…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements

Sarrigiannidis

Moussa

Dobre

et al. 2020

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Brushite cements are promising bone regeneration materials with limited biological and mechanical properties. Here, we engineer a mechanically improved brushite–collagen type I cement with enhanced biological properties by use of chiral chemistry; d - and l -tartaric acid were used to limit crystal growth and increase the mechanical properties of brushite–collagen cements. The impact of the chiral molecules on the cements was examined with Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). A 3-point bend test was utilized to study the fracture toughness, and cell attachment and morphology studies were carried out to demonstrate biocompatibility. XRD and SEM analyses showed that l -, but not d -tartaric acid, significantly restrained brushite crystal growth by binding to the {010} plane of the mineral and increased brushite crystal packing and the collagen interaction area. l -Tartaric acid significantly improved fracture toughness compared to traditional brushite by 30%. Collagen significantly enhanced cell morphology and focal adhesion expression on l -tartaric acid-treated brushite cements.

show abstract

“… 17 This can lead to particle release causing inflammation and deep vein thrombosis in extreme cases. 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In contrast, l -(+)-Tar does and inhibits mineral crystal growth. 18 , 39 The theory behind this process is described in Figure 1…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements

Sarrigiannidis

Moussa

Dobre

et al. 2020

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

Chirality‐Induced Bionic Scaffolds in Bone Defects Repair—A Review

Sun

Liu

Wei

et al. 2022

Macromolecular Bioscience

View full text Add to dashboard Cite

Due to lack of amino sugar with aging, people will suffer from various epidemic bone diseases called “undead cancer” by the World Health Organization. The key problem in bone tissue engineering that is not completely resolved is the repair of critical large‐scale bone and cartilage defects. The chirality of the extracellular matrix plays a decisive role in the physiological activity of bone cells and the occurrence of bone tissue, but the mechanism of chirality in regulating cell adhesion and growth is still in the early stage of exploration. The application progress of chirality‐induced bionic scaffolds is reviewed here in bone defects repair based on “soft” and “hard” scaffolds. The aim is to summarize the effects of different chiral structures (l‐shaped and d‐shaped) in the process of inducing bionic scaffolds in bone defects repair. In addition, many technologies and methods as well as issues worthy of special consideration for preparing chirality‐induced bionic scaffolds are also introduced. It is expected that this work can provide inspiring ideas for designing new chirality‐induced bionic scaffolds and promote the development of chirality in bone tissue engineering.

show abstract

Chiral Materials: Progress, Applications, and Prospects

Niu

Zhao

Yan

et al. 2023

Small

View full text Add to dashboard Cite

Chirality is a universal phenomenon in molecular and biological systems, denoting an asymmetric configurational property where an object cannot be superimposed onto its mirror image by any kind of translation or rotation, which is ubiquitous on the scale from neutrinos to spiral galaxies. Chirality plays a very important role in the life system. Many biological molecules in the life body show chirality, such as the “codebook” of the earth's biological diversity‐DNA, nucleic acid, etc. Intriguingly, living organisms hierarchically consist of homochiral building blocks, for example, l‐amino acids and d‐sugars with unknown reason. When molecules with chirality interact with these chiral factors, only one conformation favors the positive development of life, that is, the chiral host environment can only selectively interact with chiral molecules of one of the conformations. The differences in chiral interactions are often manifested by chiral recognition, mutual matching, and interactions with chiral molecules, which means that the stereoselectivity of chiral molecules can produce changes in pharmacodynamics and pathology. Here, the latest investigations are summarized including the construction and applications of chiral materials based on natural small molecules as chiral source, natural biomacromolecules as chiral sources, and the material synthesized by design as a chiral source.

show abstract

High strength brushite bioceramics obtained by selective regulation of crystal growth with chiral biomolecules

Cited by 26 publications

References 55 publications

Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements

Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite–Collagen Bone Cements

Chirality‐Induced Bionic Scaffolds in Bone Defects Repair—A Review

Chiral Materials: Progress, Applications, and Prospects

Contact Info

Product

Resources

About