High‐strength hydrogels: Microstructure design, characterization and applications

Hua, Jiachuan; Ng, Pui Fai; Fei, Bin

doi:10.1002/polb.24725

Cited by 55 publications

(35 citation statements)

References 165 publications

(258 reference statements)

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“…For example, to seed osteoblast cells, a more rigid material is required than for culturing adipocytes [17]. However, materials characterization, tensile and compressive tests are basic methods for mechanical performance evaluation [18,19].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review

Mohapatra

Mirza

Hilles

et al. 2021

Gels

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Hydrogels are known for their leading role in biomaterial systems involving pharmaceuticals that fascinate material scientists to work on the wide variety of biomedical applications. The physical and mechanical properties of hydrogels, along with their biodegradability and biocompatibility characteristics, have made them an attractive and flexible tool with various applications such as imaging, diagnosis and treatment. The water-cherishing nature of hydrogels and their capacity to swell—contingent upon a few ecological signals or the simple presence of water—is alluring for drug conveyance applications. Currently, there are several problems relating to drug delivery, to which hydrogel may provide a possible solution. Hence, it is pertinent to collate updates on hydrogels pertaining to biomedical applications. The primary objective of this review article is to garner information regarding classification, properties, methods of preparations, and of the polymers used with particular emphasis on injectable hydrogels. This review also covers the regulatory and other commerce specific information. Further, it enlists several patents and clinical trials of hydrogels with related indications and offers a consolidated resource for all facets associated with the biomedical hydrogels.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review

Mohapatra

Mirza

Hilles

et al. 2021

Gels

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show abstract

“…This may be due to its relatively poor tensile strength. At a tensile strength of 0.128 MPa, Hussain et al [ 88 ] found their glycogen-derived hydrogel to have an average value amongst the group, and certainly inferior to other biopolymer-derived hydrogels like chitosan and gelatine, as collated in a review by Hua et al [ 88 , 89 , 90 , 91 ]. However, the glycogen-derived hydrogel demonstrated superior elongation at fracture, reaching 810% strain.…”

Section: The History Contemporary Status and Future Applicationsmentioning

confidence: 99%

Biomedical Applications of Bacteria-Derived Polymers

et al. 2021

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Plastics have found widespread use in the fields of cosmetic, engineering, and medical sciences due to their wide-ranging mechanical and physical properties, as well as suitability in biomedical applications. However, in the light of the environmental cost of further upscaling current methods of synthesizing many plastics, work has recently focused on the manufacture of these polymers using biological methods (often bacterial fermentation), which brings with them the advantages of both low temperature synthesis and a reduced reliance on potentially toxic and non-eco-friendly compounds. This can be seen as a boon in the biomaterials industry, where there is a need for highly bespoke, biocompatible, processable polymers with unique biological properties, for the regeneration and replacement of a large number of tissue types, following disease. However, barriers still remain to the mass-production of some of these polymers, necessitating new research. This review attempts a critical analysis of the contemporary literature concerning the use of a number of bacteria-derived polymers in the context of biomedical applications, including the biosynthetic pathways and organisms involved, as well as the challenges surrounding their mass production. This review will also consider the unique properties of these bacteria-derived polymers, contributing to bioactivity, including antibacterial properties, oxygen permittivity, and properties pertaining to cell adhesion, proliferation, and differentiation. Finally, the review will select notable examples in literature to indicate future directions, should the aforementioned barriers be addressed, as well as improvements to current bacterial fermentation methods that could help to address these barriers.

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“…The organogel‐REs possess very good mechanical properties and show an ultrahigh breaking strength of 80 MPa, which surpasses most gel materials. [ 37 , 38 , 39 , 40 , 41 ] By utilizing the luminescent colors of the organogel‐REs as the binary codes of “0” and “1,” information storage and encryption are realized in complex patterns of organogel‐REs, such as self‐information pattern, quick‐response (QR) code and barcode. Information encoded in the apparent patterns could easily be retrieved using a standard decoding program, while information encrypted in the pattern colors could only be deciphered from the color image under 365 nm illumination using a color recognition and shape detection program.…”

Section: Introductionmentioning

confidence: 99%

Highly Plasticized Lanthanide Luminescence for Information Storage and Encryption Applications

et al. 2022

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The development of new storage media to meet the demands for diverse information storage scenarios is a great challenge. Here, a series of lanthanide‐based luminescent organogels with ultrastrong mechanical performance and outstanding plasticity are developed for patterned information storage and encryption applications. The organogels possessing outstanding mechanical properties and tunable luminescent colors are prepared by electrostatic and coordinative interactions between natural DNA, synthetic ligands, and rare earth (RE) ions. The organogel‐REs can be stretched by 180 times and show an ultrastrong breaking strength of 80 MPa. A series of applications with both information storage and encryption, such as self‐information pattern, quick response (QR) code, and barcode, are successfully demonstrated by the organogel‐REs. The developed information storage systems have various advantages of good processability, high stretchability, excellent stability, and versatile design of information patterns. Therefore, the organogel‐RE‐based information storage systems are suitable for applications under different scenarios, such as flexible devices under repeating rude operations. The advancements will enable the design and development of luminescent organogel‐REs as information storage and encryption media for various scenarios.

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High‐strength hydrogels: Microstructure design, characterization and applications

Cited by 55 publications

References 165 publications

Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review

Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review

Biomedical Applications of Bacteria-Derived Polymers

Highly Plasticized Lanthanide Luminescence for Information Storage and Encryption Applications

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