High sucrose consumption during pregnancy induced ADHD-like behavioral phenotypes in mice offspring

Choi, Chang Soon; Kim, Pitna; Park, Jin Hee; Gonzales, Edson Luck; Kim, Ki Chan; Cho, Kyu Suk; Ko, Mee Jung; Yang, Sung Min; Seung, Hana; Han, Seol‐Heui; Ryu, Jong Hoon; Cheong, Jae Hoon; Shin, Chan Young

doi:10.1016/j.jnutbio.2015.07.018

Cited by 33 publications

(28 citation statements)

References 47 publications

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“…By disentangling externalizing problems, these results extend prior epidemiological evidence based on DP analysis (Jacka et al., ; Steenweg‐de Graaff et al., ) and show that maternal diet during pregnancy is more likely related to ADHD symptoms rather than conduct problems. This finding extends human and animal research data by suggesting that variations in the exposure to certain nutrients could increase the likelihood that offspring will display externalizing problems such as ADHD (Choi et al., ; Liu & Raine, ; Sullivan et al., ).…”

Section: Discussionsupporting

confidence: 74%

“…Conduct problems are indeed more likely to be affected by social variables (e.g., socioeconomic and educative disadvantage, hostile parenting) than ADHD, which is conceptualized as a neurodevelopmental disorder (Scott, ). In addition, although animal studies (e.g., those conducted in rodents) suggest that prenatal intake of fat and sucrose as well as micronutrient deficiencies are associated with enhanced ADHD‐like behaviors in offspring (Choi et al., ; Sullivan, Riper, Lockard, & Valleau, ), such an association is less consistent regarding aggressive behaviors. Second, some important confounders including maternal anxiety during pregnancy, gestational diabetes, and maternal alcohol consumption (Ornoy, Reece, Pavlinkova, Kappen, & Miller, ) have not been addressed by previous research.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort

Galèra

Heude

Forhan

et al. 2018

Child Psychology Psychiatry

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort

Galèra

Heude

Forhan

et al. 2018

Child Psychology Psychiatry

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“…Research has suggested that the adverse effects of sugar may be due to ADHD children’s inclination to consume more SSBs, but many studies have also reported the converse relationship [ 67 , 69 , 70 ]. Animal studies have also shown that prenatal sucrose consumption is a risk factor for ADHD, but this association may need to be further investigated among humans [ 71 ]. The total sugar content of popular US beverages ranged from 5.5 to 12.7 g per 100 mL [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder

Yu¹,

Chiou

et al. 2016

IJERPH

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Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood neurobehavioral conditions. Evidence of the negative effects of sugar-sweetened beverages (SSBs) on mental health has not been convincing, although a few studies have found an association between high SSB levels and attention problems in children. This study aimed to test the hypothesis that SSB consumption is associated with ADHD among children. Doctor-diagnosed ADHD cases (n = 173) and non-ADHD controls (n = 159) between age 4 to 15 were recruited. SSB consumption, socio-demographic and lifestyle characteristics of the children, as well as of their mothers’ characteristics during pregnancy, were collected using a questionnaire. Blood lead levels and polymorphisms of two commonly verified dopaminergic-related genes (the D4 dopamine receptor gene DRD4 and the dopamine transporter gene DAT1) were also analyzed. There was a dose-response relationship between SSB consumption and ADHD. After covariates were adjusted, children who consumed SSBs at moderate levels and high levels had 1.36 and 3.69 odds, respectively, of having ADHD, compared with those who did not consume SSBs (p for trend < 0.05). Similar results were obtained when females were excluded. Our findings highlighted the adverse correlation between SSB consumption and ADHD and indicated a dose-response effect even after covariates were adjusted.

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“…Recent studies suggested that excessive SUC consumption also induces brain dysfunctions, such as learning impairments and addiction-like behavior (Reichelt et al, 2015;Abbott et al, 2016;Wiss et al, 2018). Excessive SUC intake during pregnancy in rodents has also been reported to induce ADHD-like behavioral alterations with increased striatal DAT expression in offspring (Choi et al, 2015). Our study suggests that excessive SUC and SAC consumptions during the juvenile period induce an assortment of behavioral and neural alterations, some of which could further interact with maturation processes during adolescence, consequently causing both concurrent juvenile and adult expressions of alterations.…”

Section: Discussionmentioning

confidence: 99%

Concurrent and Delayed Behavioral and Monoamine Alterations by Excessive Sucrose Intake in Juvenile Mice

et al. 2020

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Our daily diet in the modern society has substantially changed from that in the ancient past. Consequently, new disorders associated with such dietary changes have emerged. For instance, excessive intake of compounds, such as sucrose (SUC), has recently been reported to induce pathological neuronal changes in adults, such as food addiction. It is still largely unclear whether and how excessive intake of such nutrients affects neurodevelopment. We investigated changes in behavior and monoamine signaling caused by excessive, semi-chronic intake of SUC and the noncaloric sweetener saccharin (SAC) in juvenile mice, using a battery of behavioral tests and high-performance liquid chromatography. Both SUC and SAC intake induced behavioral alterations such as altered amphetamine responses, sucrose preference, stress response, and anxiety, but did not affect social behavior and cognitive function such as attention in juvenile and adult mice. Moreover, SUC and SAC also altered dopamine and serotonin transmission in mesocorticolimbic regions. Some of these behavioral and neural alterations were triggered by SAC and SUC but others were distinct between the treatments. Moreover, alterations induced in juvenile mice were also different from those observed in adult mice. These results suggest that excessive SUC and SAC intake during the juvenile period may cause concurrent and delayed behavioral and monoamine signaling alterations in juvenile and adult mice, respectively.

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High sucrose consumption during pregnancy induced ADHD-like behavioral phenotypes in mice offspring

Cited by 33 publications

References 47 publications

Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort

Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort

Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder

Concurrent and Delayed Behavioral and Monoamine Alterations by Excessive Sucrose Intake in Juvenile Mice

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