High-throughput transcriptomics reveals the mechanisms of nanopesticides – nanoformulation, commercial formulation, active ingredient – finding safe and sustainable-by-design (SSbD) options for the environment

Abstract

Nanoformulations are developed to offer controlled release of active ingredients (a.i.) and thus aim to keep functionality while having a smaller environmental footprint. This means that nanoformulations aim to comply...

Molecular mechanisms of zinc toxicity in the potworm Enchytraeus crypticus, analysed by high-throughput gene expression profiling

“…Such a response pattern has been also observed with other chemicals such as phenanthrene (Roelofs et al, 2016), nickel (Gomes et al, 2019a), and silver nanomaterials (Gomes et al, 2017), but not for all, e.g. copper nanomaterials (Gomes et al, 2018) or atrazine, including its nanoformulation (Gomes et al, 2021). Such a dose-dependent increase in the number of DEGs was not observed for E. albidus when exposure to Zn increased from EC50 to EC90 (Novais et al, 2012a).…”

“…for silver (Gomes et al, 2017) and copper nanomaterials (Gomes et al, 2018)). On the other hand, for nickel (Gomes et al, 2019a) and atrazine (Gomes et al, 2021), a higher transcriptional response was observed after 7 days compared to 3 days. Although the gene/molecular responses precede the effects at higher levels of biological organization, the temporal pattern can be chemical specific, besides species specificity (Novais et al, 2012a).…”

Assessing the Fate of Superparamagnetic Iron Oxide Nanoparticles Carrying Usnic Acid as Chemical Cargo on the Soil Microbial Community

“…Soil microbial community maintenance depends on their homeostatic ability to face the complexity of exogenous environmental changes and disturbances, , such as nanoenabled pesticides and biopesticides. , The effect of these materials on soil microbiota can be evaluated by the strength of connectivity among elements interacting in a biological network such as the approach proposed by Amzallag. , A systemic approach was used to evaluate the global connectance of the soil microbial community ( Cg Total ). The Cg Total results revealed a decline in the stability of the microbial community, as can be seen, by the reduction in connection strength among the evaluated parameters (Figure ).…”