Higher levels of cardiorespiratory fitness keep liver mitochondria happy!

Cuthbertson, Daniel J.; Davies, Kelly A Bowden

doi:10.1113/jp274592

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…Lastly, defective mitochondrial biogenesis is another mechanism underlying MetS pathology in skeletal muscle, liver, and pancreas, in conjunction with impaired insulin signaling and glucose metabolism. On the other hand, high CRF protects from MetS by enhancing insulin sensitivity, glucose metabolism, and fatty acid oxidation [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Cardiorespiratory Fitness and Metabolic Syndrome in Korean Older Adults

Kim

2022

IJERPH

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Background: Little is known about the relationship between non-exercise-based estimation of cardiorespiratory fitness (eCRF) and metabolic syndrome (MetS) in Korea. The current study examined the prognostic role of eCRF in the risk stratification of MetS in a representative sample of Korean older adults (1822 men and 3069 women). Methods: The data used in the current study were extracted from the Korea National Health and Nutrition Examination Surveys IV and V. eCRF was obtained using a previously validated algorithm. MetS was defined according to the National Cholesterol Education Program definition with the acceptance of a Korean-specific waist circumference cutoff point. Results: Lower eCRF was significantly correlated with abnormalities in several components of MetS, including abdominal obesity, elevated glucose, elevated triglycerides, and decreased high-density lipoprotein cholesterol. Furthermore, there was an inverse linear relationship between MetS prevalence and eCRF levels; higher eCRF was significantly and independently associated with lower prevalence of MetS. Conclusion: The current findings suggest that eCRF can be adopted as a prognostic measure in determining the risk for MetS for elderly persons.

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Section: Discussionmentioning

confidence: 99%

Association between Cardiorespiratory Fitness and Metabolic Syndrome in Korean Older Adults

Kim

2022

IJERPH

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“…Since patients with NAFLD die as frequently from CVD events as from end‐stage liver disease, 5‐8 it is important to understand the factors that contribute to low CRF because low levels of fitness might explain (at least in part) the increased risk of CVD in such patients. It has been suggested that reduced hepatic mitochondrial function may be linked to low CRF as hepatic mitochondrial dysfunction is an important feature of NAFLD 9 . However, there are no studies to date that have examined the relationship between CRF and hepatic mitochondrial function in patients with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that reduced hepatic mitochondrial function may be linked to low CRF as hepatic mitochondrial dysfunction is an important feature of NAFLD. 9 However, there are no studies to date that have examined the relationship between CRF and hepatic mitochondrial function in patients with NAFLD. Furthermore, it is important to elucidate the key factors that contribute to CRF in NAFLD, since a better understanding of these factors would provide a better insight into the potential for improving CRF, to reduce CVD risk.…”

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confidence: 99%

Factors independently associated with cardiorespiratory fitness in patients with non‐alcoholic fatty liver disease

Afolabi

Scorletti

Calder

et al. 2020

Liver International

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Low cardiorespiratory fitness (CRF) is associated with non‐alcoholic fatty liver disease (NAFLD) and low CRF is an important risk factor for cardiovascular disease. The factors that influence CRF in NAFLD are poorly understood and it has been suggested that reduced hepatic mitochondrial function (HMF) may be linked to low CRF. Therefore, our aim was to determine the factors associated with CRF in NAFLD. Methods Ninety‐seven patients with NAFLD were studied. CRF was assessed by treadmill testing and expressed as maximal O2 consumption (VO2 peak) per lean body mass. HMF was assessed by the 13C‐ketoisocaproate breath test. Multivariable linear regression modelling was undertaken to test the independence of associations with CRF. Results Mean (SD) age was 51 (13) years and 61% were men. With CRF as the outcome, age (B coefficient −0.3, 95%CI −0.4, −0.2, P < .0001), total body fat mass (B coefficient −0.2, 95%CI −0.3, −0.05, P = .01), type 2 diabetes mellitus (T2DM) (B coefficient −3.6, 95%CI −1.1, −6.1, P = .005), smoking status (B coefficient −5.7, 95%CI −1.9, −9.5, P = .004), serum γ‐glutamyl transferase (GGT) (B coefficient −0.04, 95%CI −0.05, −0.02, P < .0001), HMF (B coefficient −0.5, 95%CI −0.8, −0.1, P = .01) and diastolic function (B coefficient 0.1, 95%CI 0.05, 0.13, P < .0001) were independently associated with CRF. This model explained 60% of the total variance in CRF (R2 = 0.6, P < .0001); and this model with GGT alone explained 24% of the variance in CRF. Conclusions In patients with NAFLD, HMF is independently associated with CRF and a model with GGT alone explained most of the variance in CRF.

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“…The results found showed that the group that practiced physical training, produced a higher level of produced speed, in addition to higher levels of lactate in response to effort, associated with these results there was a bradycardia response in these animals in 21% in relation to the sedentary group. This demonstrates that aerobic exercise was able to produce significant adaptations in the cardiovascular system [31,51] .…”

Section: Nafld Mitochondria and Aerobic Exercisementioning

confidence: 85%

Effects of Aerobic Physical Training in Non-Alcoholic Fat Hepatic Disease Aspects Related to Mitochondrial Biogenesis and Oxidative Stress: A Review

Fernandes

Santos

Lima

et al. 2020

Journal of Gastroenterology and Hepatology Research

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Higher levels of cardiorespiratory fitness keep liver mitochondria happy!

Cited by 6 publications

References 5 publications

Association between Cardiorespiratory Fitness and Metabolic Syndrome in Korean Older Adults

Association between Cardiorespiratory Fitness and Metabolic Syndrome in Korean Older Adults

Factors independently associated with cardiorespiratory fitness in patients with non‐alcoholic fatty liver disease

Effects of Aerobic Physical Training in Non-Alcoholic Fat Hepatic Disease Aspects Related to Mitochondrial Biogenesis and Oxidative Stress: A Review

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