Highly Sensitive Electrochemical Impedance- Based Biosensor for Label-Free and Wide Range Detection of Fibrinogen Using Hydrothermally Grown AlFeO<sub>3</sub> Nanospheres Modified Electrode

Durai, Lignesh; Badhulika, Sushmee

doi:10.1109/jsen.2020.3032219

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…This structure shape indicates that the sample x = 1 can easily permit absorption and condensation of water vapor inside. Similar results are reported in the literature by [ 28 , 29 ].…”

Section: Resultssupporting

confidence: 93%

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

Petrila

Tudorache

2022

Materials

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The effects of Sb3+ cations substitution on the structural, magnetic and electrical properties of Al1−xSbxFeO3 multiferroic perovskite are investigated. The partial or total substitution of Al3+ cations with Sb3+ cations, in stoichiometric composition Al1−xSbxFeO3 (x = 0.00, 0.25, 0.50, 0.75 and 1.00) were made in order to identify composite materials with sensors applicative properties. Multiferroic perovskite samples were prepared following technology of the ceramic solid-state method, and the thermal treatments were performed in air atmosphere at 1100 °C temperature. The X-ray diffraction studies have confirmed the phase composition of samples and scanning electron microscopy the shape of the crystallites has been evidenced. The perovskite material was subjected to representative magnetic investigations in order to highlight substitutions characteristics. Investigations on electrical properties have evidenced the substitution dependence of relative permittivity and electrical resistivity under humidity influence and the characteristics of humidity sensors based on this material. The results are discussed in term of microstructural changes induced by the substitutions degree and its sensor applicative effects.

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“…This structure shape indicates that the sample x = 1 can easily permit absorption and condensation of water vapor inside. Similar results are reported in the literature by [ 28 , 29 ].…”

Section: Resultssupporting

confidence: 93%

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

Petrila

Tudorache

2022

Materials

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“…This is supported by the formation of sharp concentrated peak at 2θ approx = 33.72. The other diffraction peaks obtained are indexed to JCPDS card #044-4713 which proves that AlFeO 3 is of Pna2 1 space group [17]. Since, no other diffraction peak is noted in the whole spectrum, the AlFeO 3 nanorods are highly pure.…”

Section: Physicochemical Analysismentioning

confidence: 76%

A high performance lead-free flexible piezoelectric nanogenerator based on AlFeO₃ nanorods interspersed in PDMS matrix for biomechanical energy scavenging to sustainably power electronics

Bhattacharyya

Badhulika

2023

Nanotechnology

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Since lead-based piezoelectric nanogenerators (PENGs) possess serious health risks, environmental problems, proper disposal issues, and biocompatibility concerns, this work presents the fabrication of a flexible piezoelectric nanogenerator utilizing lead-free orthorhombic AlFeO3 nanorods for biomechanical energy scavenging to sustainably power electronics. Hydrothermal technique is used to synthesize the AlFeO3 nanorods and the PENG was fabricated on Indium tin oxide (ITO) coated Polyethylene terephthalate (PET) flexible film with AlFeO3 nanorods interspersed in polydimethylsiloxane (PDMS). Transmission Electron Microscopy (TEM) proved that the AlFeO3 nanoparticles are of nanorods shape. Through X-Ray Diffraction (XRD), it is validated that AlFeO3 nanorods have orthorhombic phase and crystalline structure. A high piezoelectric charge coefficient (d33) of 400 pm V-1 is obtained from the Piezoelectric Force Microscopy (PFM) of AlFeO3 nanorods. With optimized concentration of AlFeO3 in the polymer matrix, an open circuit voltage (VOC) of 30.5 V, current density (JC) of 0.7888±0.0001 µA cm-2 and an instantaneous power density of 240.6 mW m-2 are obtained under the application of a force of 1.25 kgf. To investigate the nanogenerator's practical utility, the PENG is used for lighting multiple LEDs, charging of a capacitor and as a pedometer via biomechanical energy harvesting. Hence, it can be employed for developing various self-powered wearable electronics such as flexible skin, artificial cutaneous sensors, etc.

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“…Since biological components were used, storage conditions will largely affect the performance and stability. Recently, Durai and Badhulika [34] developed a simple impedimetric sensor by modifying a screen-printed carbon electrode with aluminum ferrite nanoparticles synthesized via the hydrothermal method. It has a wide linear range of detection and very low LOD, but the material synthesis is a comparatively time-consuming process compared to the present work.…”

Section: Performance Comparisonmentioning

confidence: 99%

Binary Ni–Fe layered double hydroxide on flexible nickel foam for the wide-range voltammetric detection of fibrinogen in simulated body fluid

Mukundan,

Badhulika

2023

Nanotechnology

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Fibrinogen, a circulating glycoprotein in the blood, is a potential biomarker of various health conditions. This work reports a flexible electrochemical sensor based on Ni-Fe layered double hydroxide (Ni-Fe LDH) coated on Nickel foam (Ni-Fe LDH/NF) to detect fibrinogen in simulated human body fluid (or blood plasma). The nanoflakes like morphology and hexagonal crystal structure of LDH,synthesized via urea hydrolysis assisted precipitation technique, are revealed by scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD) techniques, respectively. The fabricated sensor exhibits linearity in a wide dynamic range covering the physiological concentration from 1 ng/ml to 10 mg/ml with a sensitivity of 0.0914 mA (ng/ml)-1(cm)-2. This LDH-based sensor is found to have a limit of detection (LOD) of 0.097 ng/ml and a limit of quantification (LOQ) of 0.294 ng/ml (S/N=3.3). The higher selectivity of the sensor towards fibrinogen protein is verified in the presence of various interfering analytes such as dopamine, epinephrine, serotonin, glucose, potassium, chloride, and magnesium ions. The sensor is successful in the trace-level detection of fibrinogen in simulated body fluid with excellent recovery percentages ranging from 99.5% to 102.5%, proving the synergetic combination of 2D Ni-Fe layered double hydroxide and 3D nickel foam as a promising platform for electrochemical sensing that has immense potential in clinical applications.

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Highly Sensitive Electrochemical Impedance- Based Biosensor for Label-Free and Wide Range Detection of Fibrinogen Using Hydrothermally Grown AlFeO₃ Nanospheres Modified Electrode

Cited by 10 publications

References 27 publications

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

A high performance lead-free flexible piezoelectric nanogenerator based on AlFeO₃ nanorods interspersed in PDMS matrix for biomechanical energy scavenging to sustainably power electronics

Binary Ni–Fe layered double hydroxide on flexible nickel foam for the wide-range voltammetric detection of fibrinogen in simulated body fluid

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Highly Sensitive Electrochemical Impedance- Based Biosensor for Label-Free and Wide Range Detection of Fibrinogen Using Hydrothermally Grown AlFeO3 Nanospheres Modified Electrode

Cited by 10 publications

References 27 publications

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

Influence of Sb3+ Cations on the Structural, Magnetic and Electrical Properties of AlFeO3 Multiferroic Perovskite with Humidity Sensors Applicative Characteristics

A high performance lead-free flexible piezoelectric nanogenerator based on AlFeO3 nanorods interspersed in PDMS matrix for biomechanical energy scavenging to sustainably power electronics

Binary Ni–Fe layered double hydroxide on flexible nickel foam for the wide-range voltammetric detection of fibrinogen in simulated body fluid

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Highly Sensitive Electrochemical Impedance- Based Biosensor for Label-Free and Wide Range Detection of Fibrinogen Using Hydrothermally Grown AlFeO₃ Nanospheres Modified Electrode

A high performance lead-free flexible piezoelectric nanogenerator based on AlFeO₃ nanorods interspersed in PDMS matrix for biomechanical energy scavenging to sustainably power electronics