Highly sensitive impedimetric immunosensor based on single-walled carbon nanohorns as labels and bienzyme biocatalyzed precipitation as enhancer for cancer biomarker detection

Yang, Fan; Han, Jing; Zhuo, Ying; Yang, Zhehan; Chai, Yaqin; Yuan, Ruo

doi:10.1016/j.bios.2013.12.040

Cited by 100 publications

(52 citation statements)

References 22 publications

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“…Yang et al developed another sandwich type device, based on a GCE treated with gold and graphene nanoparticles and then incubated with anti-AFP. [116] After incubation in AFP, the sensor was treated with carboxylated single-wall carbon nanohorns that were treated with anti-AFP, GOx, and HRP. AFP increased the resistance of the sensor due to the formation of precipitate.…”

Section: 0 Protein and Biomarkersmentioning

confidence: 99%

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Yang

Denno

Pyakurel

et al. 2015

Analytica Chimica Acta

494

263

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Carbon nanomaterials are advantageous for electrochemical sensors because they increase the electroactive surface area, enhance electron transfer, and promote adsorption of molecules. Carbon nanotubes (CNTs) have been incorporated into electrochemical sensors for biomolecules and strategies have included the traditional dip coating and drop casting methods, direct growth of CNTs on electrodes and the use of CNT fibers and yarns made exclusively of CNTs. Recent research has also focused on utilizing many new types of carbon nanomaterials beyond CNTs. Forms of graphene are now increasingly popular for sensors including reduced graphene oxide, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers. In this review, we compare different carbon nanomaterial strategies for creating electrochemical sensors for biomolecules. Analytes covered include neurotransmitters and neurochemicals, such as dopamine, ascorbic acid, and serotonin; hydrogen peroxide; proteins, such as biomarkers; and DNA. The review also addresses enzyme-based electrodes that are used to detect non-electroactive species such as glucose, alcohols, and proteins. Finally, we analyze some of the future directions for the field, pointing out gaps in fundamental understanding of electron transfer to carbon nanomaterials and the need for more practical implementation of sensors.

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Section: 0 Protein and Biomarkersmentioning

confidence: 99%

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Yang

Denno

Pyakurel

et al. 2015

Analytica Chimica Acta

494

263

View full text Add to dashboard Cite

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“…Another procedure, which guaranties diffusion hindering (then efficient transduction) independently of the size of the targets and probes, was interestingly reported by Yang et al [46] who described detection of α-fetoprotein (AFP) with the use of single-walled carbon nanohorns. Based on a sandwich-type immunoreaction, a bienzymatic (HRP and GOx) cascade was used for transduction and amplification (Figure 7C,D).…”

Section: Discussionmentioning

confidence: 99%

“…Adapted from [45], Copyright 2016, with permission from Elsevier; ( C ) Schematic representation of electrode modification by the nanohorns–bienzyme–Ab 2 complex, for AFP detection; ( D ) Nyquist diagrams of bienzyme/Ab 2 /SWCNHs bioconjugates, for various AFP concentrations. Adapted from [46], Copyright 2014, with permission from Elsevier.…”

Section: Figurementioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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Immunosensors have experienced a very significant growth in recent years, driven by the need for fast, sensitive, portable and easy-to-use devices to detect biomarkers for clinical diagnosis or to monitor organic pollutants in natural or industrial environments. Advances in the field of signal amplification using enzymatic reactions, nanomaterials such as carbon nanotubes, graphene and graphene derivatives, metallic nanoparticles (gold, silver, various oxides or metal complexes), or magnetic beads show how it is possible to improve collection, binding or transduction performances and reach the requirements for realistic clinical diagnostic or environmental control. This review presents these most recent advances; it focuses first on classical electrode substrates, then moves to carbon-based nanostructured ones including carbon nanotubes, graphene and other carbon materials, metal or metal-oxide nanoparticles, magnetic nanoparticles, dendrimers and, to finish, explore the use of ionic liquids. Analytical performances are systematically covered and compared, depending on the detection principle, but also from a chronological perspective, from 2012 to 2016 and early 2017.

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“…In this study, the capture probes were assembled on the surface of the electrodes by covalent binding with the carboxyl group of the MWCNTs. The nanotubes provided a favorable platform and increased the guanine oxidation, which led to the prepared biosensor presented high selectivity and good reproducibility …”

Section: Cnms Used In Biosensorsmentioning

confidence: 99%