Histamine-2 receptor antagonist famotidine modulates cardiac stem cell characteristics in hypertensive heart disease

Saheera, Sherin; Potnuri, Ajay Godwin; Nair, R. V.

doi:10.7717/peerj.3882

Cited by 4 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drugs like Famotidine (tradename; Pepcid) are histamine receptor antagonists that are routinely used to treat, and prevent certain types ulcers, and to treat conditions that cause the stomach to produce too much acid, and also to treat gastroesophageal reflux disease condition. Clinical evidence of the role of histamine in heart has been well documented, and histamine receptor antagonist in hypertension are cardioprotective [15][16][17]. Interestingly, HCQ is unique in the sense that, at low doses, it mitigates or blunts both the virus's direct effects, as well as the immune reaction/response.…”

Section: Introductionmentioning

confidence: 99%

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Tyagi

Singh

2021

Mol Cell Biochem

View full text Add to dashboard Cite

is caused by a coronavirus that is also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and is generally characterized by fever, respiratory inflammation, and multi-organ failure in susceptible hosts. One of the first things during inflammation is the response by acute phase proteins coupled with coagulation. The angiotensinogen (a substrate for hypertension) is one such acute phase protein and goes on to explain an association of covid-19 with that of angiotensin-converting enzyme-2 (ACE2, a metallopeptidase). Therefore, it is advisable to administer, and test the efficacy of specific blocker(s) of angiotensinogen such as siRNAs or antibodies to covid-19 subjects. Covid-19 activates neutrophils, macrophages, but decreases T-helper cells activity. The metalloproteinases promote the activation of these inflammatory immune cells, therefore; we surmise that doxycycline (a metalloproteinase inhibitor, and a safer antibiotic) would benefit the covid-19 subjects. Along these lines, an anti-acid has also been suggested for mitigation of the covid-19 complications. Interestingly, there are three primary vegetables (celery, carrot, and long-squash) which are alkaline in their pH-range as compared to many others. Hence, treatment with fresh juice (without any preservative) from these vegies or the antioxidants derived from purple carrot and cabbage together with appropriate anti-coagulants may also help prevent or lessen the detrimental effects of the covid-19 pathological outcomes. These suggested remedies might be included in the list of putative interventions that are currently being investigated towards mitigating the multi-organ damage by Covid-19 during the ongoing pandemic.

show abstract

Section: Introductionmentioning

confidence: 99%