Histamine Release Following Pancuronium

Buckland, R. W.; Avery, Anthony

doi:10.1093/bja/45.5.518

Cited by 27 publications

(4 citation statements)

References 23 publications

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“…In addition, histamine can produce increases in Pa CO2 secondary to an increase in pulmonary deadspace [24], and increases in Pa CO2 can in turn produce increases in cerebral blood flow [25] and cerebral electrical excitation [26]. Atracurium is reported to release histamine in approximately one-third the amount noted following the administration of tubocurarine [27], while pancuronium and vecuronium do not readily release histamine [28,29]. Despite histamine release after atracurium, we recently demonstrated no significant alterations in CBF in dogs given massive doses of either atracurium or pancuronium during 1.0 MAC halothane anaesthesia [6].…”

Section: Discussionmentioning

confidence: 99%

Effects of Atracurium, Vecuronium or Pancuronium Pretreatment on Lignocaine Seizure Thresholds in Cats

Lanier¹,

Sharbrough²,

Michenfelder³

1988

British Journal of Anaesthesia

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Among the non-depolarizing neuromuscular blocking drugs, atracurium appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals. This effect is attributed to the atracurium metabolite, laudanosine. The following studies were performed to determine if pretreatments with the non-depolarizing neuromuscular blockers pancuronium, atracurium or vecuronium would differ in their effects on the seizure threshold of lignocaine. Adult mongrel cats were anaesthetized with 1.0 MAC halothane in oxygen and nitrogen. Ventilation, blood-gas tensions, acid-base balance and temperature were controlled. Cats received pancuronium 0.2 mg kg 1 i.v. (n = 7), atracurium 1.0 mg kg-1 i.v. (n = 7) or vecuronium 0.2 mg kg-1 i.v. (n = 7). Ten minutes after the administration of the myoneural blocker, all cats received lignocaine 4 mg kg-1 min-1 i.v. until the onset of EEG evidence of generalized seizure activity. At seizure onset, there were no statistically significant differences among the cumulative lignocaine doses or the serum lignocaine concentrations in cats pretreated with pancuronium, atracurium or vecuronium.

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Section: Discussionmentioning

confidence: 99%

Effects of Atracurium, Vecuronium or Pancuronium Pretreatment on Lignocaine Seizure Thresholds in Cats

Lanier¹,

Sharbrough²,

Michenfelder³

1988

British Journal of Anaesthesia

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“…For most drugs the elevation of plasma histamine especially during anaphylaxis has to be shown in future, although a large variety of them are thought to be powerful liberators of histamine [4,53,54]. Liberation of histamine by contrast media was discussed already by MANY [40].…”

Section: Introductionmentioning

confidence: 99%

Contrast media as histamine liberators in man

1974

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6 minutes after Joduron | 70% (0.5 ml/kg), Biligrafin | 30% (0.4 ml/kg), Urografin | 60% (0.5 ml/kg), Urovison | 58% (0.5 ml/kg), Urovist | 65% (0.75 ml/kg) and Conray | 70% (0.5 ml/kg) (within 1 minute injected) the level of circulating histamine in plasma is increased from less than 1.0 ng/ml to 2.0-2.5 ng/ml. The elevated levels return to normal within 20 minutes, in the case of Joduron | 70% and Biligrafin | 30% slower than after the other contrast media. Urivison | 30%, infused over 4 minutes (total dose 4 ml/kg), as dextrose 50%-solution (0.5 ml/kg) failed to change histamine concentration in plasma. Obviously the histamine liberating effect of the contrast media is a specific effect of these agents.

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“…Because of increased use of synthetic neuromuscular blocking drugs, there has been an increase in the number of reported cases of hypersensitivity reactions, caused partly by immunological mechanisms (reaginic) [1] and in the majority of cases by non-immunological factors (release of histamine, complement activation etc.) [2,3].…”

mentioning

confidence: 99%

“…Pancuronium is well tolerated, but cases of undesirable secondary reactions have been reported [2][3][4].…”

mentioning

confidence: 99%

Pancuronium Allergy: A Case Report

Patriarca

Nucera

Schiavino

et al. 1989

British Journal of Anaesthesia

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A case of anaphylactic shock to pancuronium bromide is described in which a type I immunological reaction occurred. A 33-yr-old male anaesthetist, with no family or personal history of allergy, collapsed soon after induction of anaesthesia. The drugs used included fentanyl, droperidol, thiopentone and pancuronium. Diffuse erythema occurred, with probable cardiac arrest. The patient was treated with cardiac massage, sympathomimetics and cortisone, and made a complete recovery. Examination (skin tests, passive transfer according to Prausnitz and Küstner, in vitro lymphocyte transformation test, total IgE assay) revealed that the allergic reaction was to pancuronium bromide.

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Histamine Release Following Pancuronium

Cited by 27 publications

References 23 publications

Effects of Atracurium, Vecuronium or Pancuronium Pretreatment on Lignocaine Seizure Thresholds in Cats

Effects of Atracurium, Vecuronium or Pancuronium Pretreatment on Lignocaine Seizure Thresholds in Cats

Contrast media as histamine liberators in man

Pancuronium Allergy: A Case Report

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