Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide

Pierpaoli, Simone; Marzocca, Cosimo; Bello, M. G. Di; Schunack, Walter; Mannaioni, P. F.; Masini, Emanuela

doi:10.1007/s00011-003-1191-7

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…However, rat hearts do not possess functional H 2 -histamine receptors. After a myocardial infarction, histamine is released, at least in part, from mast cells in the myocardium ( Pierpaoli et al, 2003 ). Indeed, the extent of the increase in histamine in the plasma in dogs after coronary occlusion was correlated with the severity of the arrhythmias, which Wolff and Levi (1988) showed in their review.…”

Section: Roles Of Histamine and Histamine Receptors In Cardiac Diseasementioning

confidence: 99%

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Neumann¹,

Kirchhefer²,

Dhein³

et al. 2021

Front. Pharmacol.

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This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electrophysiological effects on the mammalian heart, will then be discussed in context. The potential clinical role of cardiac H2-histamine-receptors in cardiac diseases will be examined. The use of H2-histamine receptor agonists to acutely increase the force of contraction will be discussed. Special attention will be paid to the potential role of cardiac H2-histamine receptors in the genesis of cardiac arrhythmias. Moreover, novel findings on the putative role of H2-histamine receptor antagonists in treating chronic heart failure in animal models and patients will be reviewed. Some limitations in our biochemical understanding of the cardiac role of H2-histamine receptors will be discussed. Recommendations for further basic and translational research on cardiac H2-histamine receptors will be offered. We will speculate whether new knowledge might lead to novel roles of H2-histamine receptors in cardiac disease and whether cardiomyocyte specific H2-histamine receptor agonists and antagonists should be developed.

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Section: Roles Of Histamine and Histamine Receptors In Cardiac Diseasementioning

confidence: 99%

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Neumann¹,

Kirchhefer²,

Dhein³

et al. 2021

Front. Pharmacol.

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“…It emerges clearly that, in addition to the respiratory tract, the cardiovascular system is a major target of anaphylactic reaction, due to the striking vascular and cardiac effects of mediators derived from activation of tissue mast cell and circulating basophils, such as histamine (in the short term) and arachidonic acid metabolites and chemokines (in the longer term). Detailed analysis of the well-known actions of these mediators on peripheral blood vessels-chiefly vasodilatation and increased endothelial permeability [5]-is beyond the scope of this article, which is rather focused on the cardiac effects of IgE-mediated allergic disease and its regulation by histamine and gaseous autacoids, such as nitric oxide (NO) and carbon monoxide (CO).…”

Section: Introductionmentioning

confidence: 99%

Cardiac anaphylaxis: Pathophysiology and therapeutic perspectives

Bani

Nistri²,

Mannaioni³

et al. 2006

Curr Allergy Asthma Rep

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Cardiac anaphylaxis refers to the functional and metabolic changes in the heart caused by the anaphylactic release of histamine and vasoactive products of arachidonic acid cascade by mast cells and basophils. As in most type I hypersensitivity-based diseases, histamine plays a key role in the pathophysiology of cardiac anaphylaxis. In the heart, mast cell activation and histamine release are controlled by multiple endogenous mechanisms, including adrenergic neural control, histamine-dependent negative feedback operated through H2 receptors, and the endogenous generation of nitric oxide (NO) and carbon monoxide (CO). All these mechanisms can be targeted by substances that have revealed a clear-cut effect in blunting cardiac anaphylaxis in experimental animal models, and could be developed as potential, novel anti-anaphylactic drugs. In this article, we discuss new findings and significant trends related to this topic.

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“…Although this eNOS upregulation may be protective under normal circumstances, as it increases NO production, it may become harmful under conditions of oxidative stress when eNOS produces reactive oxygen species (ROS) at the expense of NO [15–18]. Also, it is shown that histamine produces coronary dilation via H2 receptor, which is not endothelium dependent [11, 12], as well as through H2- and H3-dependent mechanism involving the generation of nitric oxide [19]. …”

Section: Introductionmentioning

confidence: 99%

Histamine Blood Concentration in Ischemic Heart Disease Patients

Zdravković

Pantović

Rosić

et al. 2011

BioMed Research International

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The aim of this study was to investigate histamine blood concentration in subjects suffering from different types of ischemic heart diseases during the period of eight days. Our results showed that the histamine blood level was associated with different types of ischemic heart diseases. The blood histamine level in all investigated patients was significantly higher when compared to control subjects (44.87 ± 1.09 ng mL−1), indicating the increase of histamine release in patients suffering from coronary diseases. In patients suffering from ACS-UA and ACS-STEMI, the second day peak of histamine level occurs (90.85 ± 6.34 ng mL−1 and 121.7 ± 6.34 ng mL−1, resp.) probably as the reperfusion event. Furthermore, our data suggest that histamine can be additional parameter of myocardial ischemia along with cardiac specific enzymes and may prove to be an excellent single prognostic marker for multitude of ischemic heart diseases.

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Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide

Abstract: These results suggest that, in isolated guinea pig hearts, histamine produces coronary dilation through an H (2 )/H (3 )-dependent mechanism involving the generation of nitric oxide.

Cited by 10 publications

References 27 publications

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Cardiac anaphylaxis: Pathophysiology and therapeutic perspectives

Histamine Blood Concentration in Ischemic Heart Disease Patients

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