Histiocytoma of the Bronchus

Plasma cell granuloma of the lung, a designation that we consider preferable to “inflammatory pseudotumor,” represents localized proliferations predominantly of mature plasma cells, with Russell bodies, reticuloendothelial cells, and intermediate forms, supported by a stroma of granulation tissue. Other cellular elements, including lymphocytes and large mononuclear cells, may coexist with the plasma cells. The latter may have a large content of cytoplasmic fat, hence the term “xanthoma” or “fibroxanthoma” applied by some. The stroma may contain interlacing or whorled masses of fibroblasts, and may be focally ossified or calcified. It is often hyalinized with an appearance similar to that of paramyloid. These lesions are usually asymptomatic, and are most commonly detected in routine chest films as circumscribed “coin” lesions, or large masses. They may be static or increase slowly in size. In a minority, they are sessile or polypoid intrabronchial masses. More than two thirds of the patients are less than 30 years of age; indeed plasma cell granulomas are prominent among the large solitary intrapulmonary lesions in children. Bacterial cultures and skin tests for mycobacteria and fungi have been negative. The prognosis is good even after lobectomy, and probably even after segmental resection. Plasma cell granulomas have structural features and a natural history quite distinct from those of sclerosing hemangioma and myeloma.

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Histiocytoma of the Bronchus

Cited by 43 publications

References 12 publications

Cultural characteristics of malignant histiocytomas and fibrous xanthomas

Cultural characteristics of malignant histiocytomas and fibrous xanthomas

Solitary mast cell granuloma (histiocytoma) of the lung.A Histopathologic, Tissue Culture and Time-Lapse Cinematographic Study

Plasma cell granulomas of the lung

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