Histochemische Studien über die Infarktausdehnung bei temporärer regionaler Myocardischämie beim Schwein

Hetzer, Roland; Balten, U.; Nevermann, L; Vykoupil, K. F.; Borst, H. G.

doi:10.1007/978-3-642-65840-2_2

Cited by 2 publications

(5 citation statements)

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“…Our own results correspond to some extent to the findings of Hetzer et al [33] and Kane et al [29]. It is suggested that in the pig early revascularization following an acute coronary occlusion exceeding 1 h appears to be of little value with regard to myocardial tissue structure and cardiac function.…”

Section: Myocardial Response To Occlusion and Reperfusionsupporting

confidence: 90%

“…Recently Hetzer et al [33] determined the relation between necrotic and resuscitated myocardium following a prolonged period of reperfusion: after a 1 h occlusion 34% of the area supplied by the temporarily occluded artery was found necrotic; after 3 h of occlusion 61 $4 and after permanent occlusion 8 1 % of the corresponding area turned out to be infarcted. Recently Hetzer et al [33] determined the relation between necrotic and resuscitated myocardium following a prolonged period of reperfusion: after a 1 h occlusion 34% of the area supplied by the temporarily occluded artery was found necrotic; after 3 h of occlusion 61 $4 and after permanent occlusion 8 1 % of the corresponding area turned out to be infarcted.…”

Section: Myocardial Response To Occlusion and Reperfusionmentioning

confidence: 99%

“…There are only a few reports of coronary reperfusion in pigs. Recently Hetzer et al [33] determined the relation between necrotic and resuscitated myocardium following a prolonged period of reperfusion: after a 1 h occlusion 34% of the area supplied by the temporarily occluded artery was found necrotic; after 3 h of occlusion 61 $4 and after permanent occlusion 8 1 % of the corresponding area turned out to be infarcted. When the irreversibly damaged zone exceeded 50% of the supplied area, the latter was entirely akinetic.…”

Section: Myocardial Response To Occlusion and Reperfusionmentioning

confidence: 99%

See 2 more Smart Citations

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Althaus

Gurtner

Baur

et al. 1977

Eur J Clin Investigation

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The effects of myocardial reperfusion have been examined following a 1 h coronary occlusion and compared to a permanent coronary ligation in pigs. Haemodynamic investigations were carried out throughout the surgical intervention and repeated after 7 days. Cellular injury was estimated by serial serum enzyme determinations (creatin phosphokinase, alpha-hydroxybutyric dehydrogenase, aspartate aminotransferase, lactic dehydrogenase) during the first 5 postoperative days; infarct size was assessed morphometrically by a histochemical staining procedure 1 week after the temporary or permanent coronary occlusion. A linear correlation was found between the logarithmically plotted peak serum activity of AST, HBDH, CPK and the morphometrically determined infarct size. Based upon enzyme and morphometrical studies no significant difference could be detected between the two experimental groups. In the animals subjected to transient coronary occlusion, however, the development of a ventricular aneurysm had been prevented to early and sustained reperfusion. Early re-establishment of coronary circulation appears to accelerate the proliferation of a more resistant granulation tissue into the infarcted area. Cardiac performance was not improved by myocardial reperfusion.

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Section: Myocardial Response To Occlusion and Reperfusionsupporting

confidence: 90%

Section: Myocardial Response To Occlusion and Reperfusionmentioning

confidence: 99%

Section: Myocardial Response To Occlusion and Reperfusionmentioning

confidence: 99%

See 1 more Smart Citation

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Althaus

Gurtner

Baur

et al. 1977

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…So far, predominantly the critical time factor under conditions of temporary total coronary artery occlusion has been studied (1, 14,23,27). So far, predominantly the critical time factor under conditions of temporary total coronary artery occlusion has been studied (1, 14,23,27).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous authors have dealt with myocardial survival after temporary occlusion of a coronary artery (1, 5,14,16,23,33). As a result of these studies, it is widely accepted that viability of an ischemic border zone is maintained by collateral blood supply (13,18,28,30,32).…”

Section: Introductionmentioning

confidence: 99%

The effect of coronary flow restriction on the viability of porcine myocardium

et al. 1982

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The effect of a prolonged (3 hours) defined coronary flow restriction on early (30 minutes) and late (24 hours) reperfusability and survival of the myocardium was studied in a closed-chest pig model. Coronary blood flow (CBF) was restricted to 51 +/- 4% (moderate flow restriction) and 36 +/- 6% (severe flow restriction) of preexisting resting flow values. Regional determination of the restricted CBF after severe flow restriction showed the anticipated extension of the ischemic area from endocardial to epicardial layers and to the lateral border zone. Upon early reperfusion a hyperemic effect was observed, which reflected the preceding degree of underperfusion. The maximal hyperemic effect was found in samples with CBF restriction to 38% of the control flow values. Twenty-four hours after blood flow restitution the hyperemic effect had disappeared. At this time control flow values had not returned, where previous CBF restriction had exceeded 50%. The amount of infarcted tissue in the area supplied by the left circumflex artery was 5.7% after moderate, and 31.6% after severe flow restriction. Morphologically the infarcted myocardium consisted of disseminated necrosis after moderate, and of confluent necrosis after severe flow restriction. At flow restriction exceeding 50%, the chances of reestablishing perfusion and thus salvaging the myocardium appear minimal.

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Histochemische Studien über die Infarktausdehnung bei temporärer regionaler Myocardischämie beim Schwein

Cited by 2 publications

References 1 publication

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings

The effect of coronary flow restriction on the viability of porcine myocardium

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