Histogenesis of Carcinoma in the Glandular Stomach of the Rat After B I Resection

Schlake, W.; Nomura, Kosuke

doi:10.1007/978-3-642-67292-7_1

Cited by 14 publications

(6 citation statements)

References 94 publications

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“…In 1979, Schlake and Nomura [31] performed gastrectomy, with the B I procedure, in male Wistar rats. At 104 weeks after the operation, a few carcinomas were found to have developed, without MNNG having been used.…”

Section: Animal Models Of Duodenogastric Reflux Without Carcinogenmentioning

confidence: 99%

Duodenogastric reflux and gastric stump carcinoma

Kondo

2002

Gastric Cancer

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Section: Animal Models Of Duodenogastric Reflux Without Carcinogenmentioning

confidence: 99%

Duodenogastric reflux and gastric stump carcinoma

Kondo

2002

Gastric Cancer

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“…[7][8][9][10][11] The variants fall into two main groups: an incomplete type shows features of both gastric and small intestinal epithelia,8 12 13 whereas a 'colonic' type has acquired characteristics of large intestine including enzymes14 and mucins.9-11 The present study was designed to examine further the significance and interrelationships of these variants.…”

mentioning

confidence: 99%

Role of intestinal metaplasia in the histogenesis of gastric carcinoma.

Jass¹

1980

J Clin Pathol

180

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SUMMARY Recent evidence suggests that intestinal metaplasia (IM) cannot be regarded as a single entity. A simple classification of IM and its variants based on histological and mucin histochemical criteria was devised, and the incidence of IM subtypes in cancerous and benign gastrectomy specimens was recorded. A particular subtype was associated with 'intestinal' cancers but not with tumours considered to arise in normal gastric epithelium (P < 0-01) or with benign lesions (P < 0 01). This subtype appeared to lack absorptive cells at light microscopic level and secreted both neutral and acid mucins, including marked amounts of sulphomucin but no O-acetyl sialomucin.

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“…Der operierte Magen wird heute neben dem Morbus M6n6trier, den neoplastischen Magenpolypen und der pernizi6sen Anfimie zu den Pr~icancerosen gerechnet, zu denen mit Einschrfinkungen auch die schwere chronische athrophische Gastritis geh6rt [6,23,25,26]. Hierbei wird insbesondere der Bereich der Magen-Darm-Anastomose bzw.…”

Section: Cell Proliferations In the Gastroenterostomic Areaunclassified

“…Beziiglich der Lokalisation der DNS-synthetisierenden Zellen in der normalen Schleimhaut des Drfisenmagens der Ratte und auch in der Corpusschleimhaut andere Tierspecies und des Menschen stimmen alle Autoren iiberein [13,19,26].…”

Section: Diskussionunclassified

“…Die fiber lange Zeit nachweisbare Erh6hung der 3H-Markierungsindices im Bereich der anastomosierten Schleimhautabschnitte und die Aufl6sung der im Driisenhalsbereich gelegenen Proliferationszone, abzulesen an den v611ig wahllosen Markierungsmustern, belegen eindrucksvoll die permanent bestehende ,,Unruhe" in den anastomosierten Schleimhautabschnitten und zeigen, warum die Anastomose als Pr/idilektionsstelle fiir das Angehen eines Carcinoms anzusehen ist [6,26,27].…”

Section: Diskussionunclassified

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Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

Meyer

Schlake²,

Nomura

1985

Langenbecks Arch Chiv

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Nowadays the resected stomach is considered to be in a precancerous state in the broader sense. Until now there have been no systematic, histoautoradiographic investigations concerning the proliferative kinetics of the resected stomach in the region of anastomosed mucosa sections. Histoautoradiographic investigations should give an answer to the following questions: 1. In which way do the proliferative kinetics of gastric mucosa in the part of the anastomosis change with increasing postoperative interval? 2. Is there a result of variations in the proliferative kinetics of the anastomotic distant mucosa of the fundus? To find an answer to these questions, 75 Wistar-rats out of 231 operated rats (Billroth's 1st principle) were selected for histoautographic analysis. The laboratory animals were killed at fixed points of time in a postoperative interval of 104 weeks of experiment and the gastrointestinal preparations were worked up and interpreted for the histoautographic analysis. During the postoperative period the 3H-labelling-indices showed a characteristic course in the part of the gastric anastomosis. After a continuous increase of the 3H-labelling indices up to the fourfold of standard values two years after the operation there was a slight decrease of the proliferative activity. But it still remained twice the normal value. In addition, extended displacements and decompositions of gastric anastomosis mucosa could be observed. However, the proliferative activity in the anastomotid distant mucosa remained unchanged. A cell proliferation of gastric anastomosis increasing considerably and demonstrated in our experiment has to be considered as promotion factor of cancer development. Anastomotic carcinomas developing during the total experiment give evidence for this.

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Histogenesis of Carcinoma in the Glandular Stomach of the Rat After B I Resection

Cited by 14 publications

References 94 publications

Duodenogastric reflux and gastric stump carcinoma

Duodenogastric reflux and gastric stump carcinoma

Role of intestinal metaplasia in the histogenesis of gastric carcinoma.

Histoautoradiographische Untersuchungen im Billroth-I-operierten Rattenmagen in Abh�ngigkeit vom postoperativen Intervall

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