Histologic Comparison of Autologous Graft-vs-Host Reaction and Cutaneous Eruption of Lymphocyte Recovery

Bauer, Diane J.; Hood, Antoinette F.; Horn, Thomas

doi:10.1001/archderm.1993.01680280043007

Cited by 47 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, we need to acknowledge that genetically identical twins are not always genetically identical. 31 Bauer et al 32 analyzed skin biopsies from 38 persons receiving autotransplants or intensive chemotherapy but no transplant for diverse cancers. In one-third of cases the reviewers were unable to distinguish the histological features of skin biopsies in those without GVHD from those reported as having grade-2 GVHD.…”

Section: Can Acute Gvhd Be Accurately Diagnosed Based On Clinical or mentioning

confidence: 99%

Autologous GVHD?

Otegbeye

Lazarus

2014

Bone Marrow Transplant

View full text Add to dashboard Cite

Section: Can Acute Gvhd Be Accurately Diagnosed Based On Clinical or mentioning

confidence: 99%

Autologous GVHD?

Otegbeye

Lazarus

2014

Bone Marrow Transplant

View full text Add to dashboard Cite

“…These areas contain large numbers of stem cells, which suggests that the target cells may be the less-differentiated epithelial stem cells, with primitive surface antigens (Sale et al, 1985). The skin changes of acute GVHD may be histologically indistinguishable from those seen in association with the eruption of lymphocyte recovery (Bauer et al, 1993). However, patients with the latter condition do not develop diarrhea or liver abnormalities.…”

Section: (B) Orial Presentationmentioning

confidence: 99%

Graft-vs.-Host Disease

Woo

Lee

Schubert

1997

Critical Reviews in Oral Biology & Medicine

134

View full text Add to dashboard Cite

Bone marrow transplantation (BMT) is the treatment of choice for many leukemias, lymphomas, bone marrow failure syndromes, and immundeficiency disorders, and is the primary and salvage therapy for many solid malignancies. With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing frequency. Graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to 70% of patients despite GVHD prophylaxis, with the skin, gastro-intestinal tract, and liver as primary target organs. Oral findings are seen in both acute and chronic GVHD. In acute GVHD, the oral lesions are often painful, erythematous, ulcerative, and desquamative. In chronic GVHD, they are lichenoid with associated erythema and ulcerations; additionally, they may be associated with a sicca syndrome characterized by xerostomia and progressive salivary gland atrophy. General principles of BMT are discussed, as are systemic and local therapeutic options for oral GVHD.

show abstract

“…5 The foregoing might be explained by the presence of a greater number of autoreactive T lymphocytes, probably involved in ES, as a result of the less intensive prior immunosuppression therapy for solid tumors than is used in hematologic malignancies. 5,19,20 Busulphan-based conditioning regimens have been described previously as related to ES development; 6 however since only 12 patients received a non-busulphan-based conditioning in this series, this association could not be studied.…”

Section: Discussionmentioning

confidence: 93%

Engraftment syndrome in children undergoing autologous peripheral blood progenitor cell transplantation

Madero

Vicent

Sevilla

et al. 2002

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:There is limited experience on engraftment syndrome (ES) in children. The present study analyzes the characteristics of ES in pediatric patients undergoing autologous peripheral blood progenitor cells transplantation (PBPCT). From 1993 to 2001, 30 of 156 patients (19.2%) who underwent PBPCT developed ES (skin rash which involved more than 27% of the body surface and temperature Ͼ38.3؇C with no compatible infectious disease etiology, during neutrophil recovery). Of the 30 patients who developed ES, 20 (66%) developed hypoxia and/or pulmonary infiltrates, seven (23%) had hepatic dysfunction, six (20%) developed renal insufficiency, 16 (53%) showed weight gain and three (10%) experienced transient encephalopathy. Multivariate analysis showed that the only positive predictive factor for developing ES was mobilization with high-dose G-CSF (12 g/kg twice daily) (RR 3.88, CI 95% 1.73-8.67; P Ͻ 0.0005). The overall transplant-related mortality (TRM) was 8.33% and this was significantly higher in the patients who developed ES than in those who did not (23% vs 4.76%; P Ͻ 0.0001). We also found a higher morbidity in patients who developed ES, expressed as a statistically significant increase in supportive care (transfusion requirement, parenteral nutrition) and increase in the length of hospital stay. In summary, we have found ES to be the most important cause of morbidity and mortality in children undergoing autologous PBPCT.

show abstract

Histologic Comparison of Autologous Graft-vs-Host Reaction and Cutaneous Eruption of Lymphocyte Recovery

Cited by 47 publications

References 7 publications

Autologous GVHD?

Autologous GVHD?

Graft-vs.-Host Disease

Engraftment syndrome in children undergoing autologous peripheral blood progenitor cell transplantation

Contact Info

Product

Resources

About