Histologic evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide in beagles

Lu, Yu; Liu, Tianjia; Li, Xiuqun; Li, Haolai; Pi, Gen-li

doi:10.1016/j.tripleo.2006.02.020

Cited by 41 publications

(36 citation statements)

References 15 publications

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“…However, similar to GI/RMGI, adhesives are acidic and have no bactericidal effects. Dental adhesives exhibited poor pulpal healing, chronic inflammation, and lack of dentin bridge formation, while the control calcium hydroxide demonstrated good pulpal healing, dentin bridge formation and no or slight inflammation 2,[49][50][51][52][53] . It is interesting to note that pulp capped directly with non-acidic bonding resin or resin composite showed a trend towards better pulp response than the ones capped with acidic primers or adhesives 51) .…”

Section: Other Materials For Pulp-cappingmentioning

confidence: 99%

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Chen¹,

Suh²

2017

Dental Materials Journal

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Direct pulp capping is the placement of a dental material directly over exposed pulp to prevent dental pulp from dying and avoid the need for root canal treatments. Calcium hydroxide and calcium silicates/mineral trioxide aggregates (MTA) have been commonly used for direct pulp capping with great success clinically. In recent years, resin-modified calcium hydroxide and calcium silicates have been developed with the advantages of precise placement, command set, and superior physical strength. As pulp capping materials would be in direct contact with the pulp, the cytotoxicity and biocompatibility is of particular importance in order to avoid pulp irritation and maintain pulp vitality. Therefore, this review article will summarize the cytotoxicity and biocompatibility of direct pulp capping materials, particularly resin-modified materials.

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Section: Other Materials For Pulp-cappingmentioning

confidence: 99%

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Chen¹,

Suh²

2017

Dental Materials Journal

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“…In recent years, dentin bonding systems (DBSs) have been examined in humans [1,4,7,[12][13][14][15][16][17][18][19] and animals [2,5,[9][10][11][20][21][22][23][24][25][26][27][28][29] as potential direct capping materials due to their superior ability to adhere to demineralised dentin tissues. Hybridisation of DBSs and diffusion of adhesives into the dentin tubules may protect the dentin against bacterial leakage and reduce secondary pulpal inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…However, long periods of cellular exposure to these monomers resulted in a significantly increased cytotoxicity [32][33][34]. Studies of human [1,4,12,15], dog [2,[22][23], monkey [24] and cat [25] teeth have reported adverse effects of the application of DBSs as pulp capping agents. Etch-andrinse bonding agents applied on pulp exposed following acid etching elicited a moderate inflammatory response in a short-term evaluation, which sometimes led to pulp necrosis [1,4,12,16].…”

Section: Introductionmentioning

confidence: 99%

“…In general, animal studies are necessary since they provide results generating a wealth of valuable information from which it is possible to extrapolate results to humans. In the animal model, it is possible to treat all the teeth identically, controlling their history, care, and extraction under laboratory conditions to provide comparative evaluation of the biocompatibility of different dental materials [23,26]. The present investigation performed on animals was aimed to provide direct information about the biocompatibility of dental materials and avoiding the exposure of humans to potentially harmful agents.…”

Section: Introductionmentioning

confidence: 99%

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Pulpo-dentin complex response after direct capping with self-etch adhesive systems

Nowicka

Parafiniuk²,

Lipski³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:The purpose of the present study was to evaluate morphologically the response of feline teeth pulp to direct pulp capping with two different self-etch adhesive systems. Twenty-four cavities in feline teeth were mechanically exposed and assigned to one of two experimental groups: AdheSE + Tetric Ceram (the ASE group), or Adper Prompt L-Pop + Filtek Supreme (the APLP group). There was also a control group Dycal Ca(OH) 2 liner + Amalgam (the CH group eight teeth), and six teeth were used as an intact control group. The animals were sacrificed after 40 days. The teeth were removed and processed for standard histological evaluation, using a scoring system for inflammatory cell response, pulp tissue disorganisation, reparative tissue formation, and the presence of bacteria. Statistical analysis revealed no significant differences between the ASE and APLP selfetching resin systems during the observation period. The majority of the specimens presented inflammatory pulp response with tissue disorganisation and a lack of dentinal bridge formation. CH capping resulted in a significantly smaller inflammatory pulp response and a considerably higher incidence of reparative dentin formation. ASE and APLP were comparably effective as direct pulp capping materials, but their application resulted in significantly greater pulp tissue damage than CH capping. Further in vivo human studies are necessary to determine which adhesive resin systems should be clinically used for direct pulp capping without incurring severe damage to the pulpal tissue.

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“…Although there is no accepted experimental mode for the early experimental assessment of restorative systems, and clinical trials still remain the ultimate test, [3][4] experimental in vitro/in vivo bond testing may predict the results of clinical studies to a certain degree. 1,[4][5] Between bond strength measurements on enamel and dentin [6][7][8] and studies related to the biocompatibility of system components [9][10][11] and spectroscopic investigations, [12][13] numerous imaging methods can help to characterize restoration systems in great detail by investigating phenomena, such as marginal integrity, microleakage and the mechanisms of mechanical adhesion (interlocking/hybridization of enamel and dentin). 14 Such experimental screenings include investigating tooth substrates of different qualities (sound/carious dentin) 8,[15][16][17][18][19] and C-factors, [20][21][22] simulation of pulpal pressure and the oral environment, [23][24][25] the application of thermal and occlusal stresses, fatigue simulation [26][27] or, for better simulation of the clinical situation, studies on in vivo restored teeth that have been in use for a certain period of time.…”

Section: Introductionmentioning

confidence: 99%

Effect of Operator-specific Handling on Tooth-composite Interface and Microleakage Formation

Schneider

Busch²,

Busch³

et al. 2009

Operative Dentistry

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SUMMARYThe aim of this in vitro study was a comparative investigation of tooth-composite interface morphology and microleakage formation after the calibrated restoration of Class II cavities with a proven multi-component, three-step, total-etch adhesive system by three experienced operators. The current study also aimed to acquire data about the well-tried adhesive system under defined laboratory conditions for further comparative assessments with other adhesives. H Schneider • I Busch • M Busch H Jentsch • M Häfer Clinical RelevanceAfter calibration of the restoration procedure, three operators experienced differences in toothcomposite interface morphology and microleakage formation. These differences reflect technique-sensitivity of the etch-and-rinse adhesive. The lowest microleakage on dentin was related to an enhanced interface integrity. After additional application of an adhesive component, sealing of the enamel and dentin was partially enhanced, but microleakage formation did not decrease. These results are helpful in the comparative evaluation of other bonding systems. Schneider & Others: Effect of Operator-specific Handling on Tooth-composite Interface & Microleakage FormationForty Class II cavities were prepared on extracted, caries-free molars. In the first study (Part A), 24 cavities were restored (n=8 each) according to the manufacturers' instructions.In the second study (Part B), 16 teeth (n=6, 4, 6) were filled in the same way; however, the last component of the same adhesive system was applied twice. The teeth were prepared for microleakage testing and morphological assessment of the composite-tooth interface by scanning electron microscopy. The three operators had differences with regard to adhesive layer formation, inter-/peritubular adhesive penetration and the formation of adhesive failures on the dentin interface and microleakage on dentin. The lowest microleakage on dentin was related to enhanced peritubular and intertubular adhesive penetration.After double application of an adhesive component (Part B), the sealing of the enamel and dentin with adhesive increased partially, and adhesive failures on dentin were partly diminished, but no distinct effects on microleakage formation were found.The results confirm the technique-sensitivity of the etch-and-rinse adhesive related to interface morphology and microleakage formation. These results are helpful in the comparative evaluation of other bonding systems.

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Histologic evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide in beagles

Cited by 41 publications

References 15 publications

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Pulpo-dentin complex response after direct capping with self-etch adhesive systems

Effect of Operator-specific Handling on Tooth-composite Interface and Microleakage Formation

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