Histologic findings after gastrocystoplasty in rabbits

Vajda, Péter; Pintér, Andrew; Magyarlaki, T.; Vastyan, Attila M.; Juhász, Zsolt; Oberritter, Zsolt; Fathi, Khaled

doi:10.1016/j.jpedsurg.2005.05.047

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…This hypothesis is based on the high incidence of chronic bacteriuria, found within this patient population [Husmann and Rathbun 2008]. In fact, it was originally hypothesized that gastrocystoplasties would be more resistant to malignant transformation than enteric cystoplasties due to the relative absence of chronic bacteriuria, 13% versus 55% respectively [Husmann and Rathbun, 2008;Baydar et al 2005;Vajda et al 2005]. Unfortunately as noted previously, this has not been found to be true.…”

Section: Etiology Of Cancer In Bladder Augmentationsmentioning

confidence: 82%

“…Gastric atrophy is a known premalignant condition that arises as a consequence of the Correa cascade. The latter phenomena is a multi-step process by which inflammation stimulates the host's immune response, the immunologic response can lead to gastric atrophy, intestinal metaplasia, epithelia dysplasia and eventually the development of invasive carcinoma [Take et al 2007;Vajda et al 2005;Qui et al 2003;Vajda and Kaiser, 2002]. An increased risk of cancer is also of concern in composite gastic enteric bladder augments, this procedure mimics that of Bilroth II procedures where gastroenterotomies (gastric jejunal anastamosis) were performed for benign disease, these procedures were later found to be associated with frequent cancer development [Husmann and Rathbun, 2008;Baydar et al 2005;Schafer et al 1983].…”

Section: Discussionmentioning

confidence: 99%

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Malignancy after gastrointestinal augmentation in childhood

Husmann

2009

Therapeutic Advances in Urology

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Patients augmented with ileal or colonic segment for a congenital bladder anomaly have a 7-8 fold and gastric augments a 14-15 fold increased risk for the development of bladder cancer over standard norms. Published data is however unable to determine if gastrointestinal bladder augmentation is an independent risk factor for cancer over the inherent risk of cancer arising from a congenitally abnormal bladder.

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Section: Etiology Of Cancer In Bladder Augmentationsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Malignancy after gastrointestinal augmentation in childhood

Husmann

2009

Therapeutic Advances in Urology

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“…This bad vascularization may be attributed to the tension lying on the long vascular pedicle of the gastric graft, by the surrounding organs. This was illustrated by Vajda et al (2005) who stated that the stomach graft has some potential disadvantages comprising a long vascular pedicle, acid secretion and theoretically Vitamin B12 malabsorption.…”

Section: Discussionmentioning

confidence: 99%

Gastric neobladder: an experimental study in dog

Seif

Aimen

Kamel

2007

Journal of Veterinary Medical Research

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The urinary bladder of 15 clinically normal dogs was excised and the ureters were implanted into an isolated, vagotomized gastric segment derived from the fundic region of the stomach. The gastric segment was closed to form a neobladder. Continence was maintained with a "nipple valve" created at the tubularized end of isolated segment of stomach. Clinical, radiological, ultrasonographical, urine and blood analysis and histopathological examination were carried out for assessment of the technique. Eleven cases showed an apparently normal bladder function. Two cases suffered from renal hydronephrosis and other two suffered from incontinence. It was concluded that gastric neobladder urinary diversion is satisfactory for clinical use in dogs.

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“…This is a multistep process by which inflammation stimulates the host's immune response. The immunologic response can lead to gastric atrophy, intestinal metaplasia, epithelia dysplasia, and eventually invasive carcinoma [17,[19][20][21]. Additionally, the gastric cystoplasty procedure mimics the Billroth II, in which a gastric-jejunal anastomosis is performed for benign disease, and has an increased frequency of cancer development [5••, 22].…”

Section: Risk Factorsmentioning

confidence: 99%

Bladder Augmentation and the Risk of Carcinoma

Padmanabhan

2011

Curr Bladder Dysfunct Rep

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Augmentation cystoplasty is the gold standard for increasing bladder capacity and improving bladder compliance in patients with refractory neurogenic bladder dysfunction. Significant long-term complications of this procedure do occur, however. The potential risk of bladder or bowel patch malignancy is concerning. The early literature has reviewed the associated risk involved with infectious sources of bladder dysfunction and augmentation. There is a paucity of data on outcomes of augmentation for noninfectious etiologies. This article reviews the pathophysiology, risk, and incidence rates as they correlate with bowel segment used, histology, risk factors, and screening recommendations for bladder augmentation-associated malignancies of noninfectious etiologies.

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Histologic findings after gastrocystoplasty in rabbits

Cited by 5 publications

References 16 publications

Malignancy after gastrointestinal augmentation in childhood

Malignancy after gastrointestinal augmentation in childhood

Gastric neobladder: an experimental study in dog

Bladder Augmentation and the Risk of Carcinoma

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