Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis

Peng, Chufang; Zhao, Yuming; Wang, Wenjun; Yuan, Yang; Qin, Man; Ge, Lihong

doi:10.1016/j.joen.2017.01.031

Cited by 39 publications

(40 citation statements)

References 27 publications

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“…Concerning the state of the pulp before the initiation of regenerative treatment, two teeth displayed irreversible pulpitis , nine had pulpal necrosis , and ten had apical periodontitis . Two teeth were completely healthy, and their pulps were extirpated , while one had previously initiated root canal treatment and lacked pulp tissue .…”

Section: Resultsmentioning

confidence: 99%

“…Then, 43 studies were excluded by title and 32 studies were excluded by abstract. Finally, 12 articles met the inclusion criteria after full‐text evaluation .…”

Section: Resultsmentioning

confidence: 99%

“…Two teeth were completely healthy, and their pulps were extirpated , while one had previously initiated root canal treatment and lacked pulp tissue . Twelve teeth were infected and two not infected . Three teeth had vital pulp or vital pulp remnants (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The radiographic findings from 12 teeth showed resolution of the apical lesion and continuation of root maturation with root lengthening, thickening of the dentinal walls and apical closure to different degrees, which were evaluated as successful by the authors . In one case, the tooth was extracted 3.5 weeks after REP, and consequently, there was insufficient time for root maturation .…”

Section: Resultsmentioning

confidence: 99%

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Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

2019

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The aim of this study was to systematically review the histological evidence of the neo-formed tissues inside the root canals of human teeth having previously received regenerative endodontic treatment. An electronic research was performed in the MEDLINE, Web of Science, Scopus and Cochrane Library databases using controlled vocabulary. The retrieved studies were screened by two reviewers according to the predetermined inclusion and extrusion criteria and were full-text-evaluated. Research resulted in 160 studies. Among them, twelve fitted the inclusion criteria and were critically appraised. The tissues formed in the root canals of immature human teeth treated with REP indicate repair or a combination of repair and regeneration. Pulp remnants and healthy periapical tissues seem to improve regeneration. The level of available evidence was low. Further clinical studies are needed in order to establish the appropriate treatment protocol related to the pretreatment status of the dental pulp and the periapical tissues.

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Section: Resultsmentioning

confidence: 99%

“…Then, 43 studies were excluded by title and 32 studies were excluded by abstract. Finally, 12 articles met the inclusion criteria after full‐text evaluation .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

2019

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“…Although this work demonstrated the potential for a pulp revascularization procedure to induce apical closure and continuous root formation in immature human teeth, the interest in this area diminished at that time [14]. Thirty years later, however, there is renewed interest in revitalization after human studies reported that connective tissues, blood vessels, dentin, and cementum-like tissues filled the root canal space after pulp revitalization procedures [15••, 16]. These data now suggest that this procedure has the potential to regenerate biological tissue if normal periapical tissues containing Hertwig’s epithelial root sheath and the apical papilla remain in a healthy state prior to a tissue engineering approach.…”

Section: Introductionmentioning

confidence: 99%

Growth Factors and Cell Homing in Dental Tissue Regeneration

Duncan

Kobayashi

Shimizu

2018

Curr Oral Health Rep

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Purpose of Review To summarize current views on the role and therapeutic potential of growth factors (GFs) within endodontic cell homing. Recent Findings Cell homing/revitalization techniques aim to regenerate dentin and pulp using endogenous cells. Clinically, revitalization has successfully created new vital tissue in necrotic permanent teeth with an open apex; however, there is no evidence of new odontoblasts, pulp tissue, or predictable extension in root length. Although the response is reparative rather than regenerative, exciting opportunities to improve these biologically-based strategies remain by (1) efficiently sequestering dentin-matrix-components (DMCs) using irrigants and dental materials (2) designing next-generation GF-releasing scaffold materials and (3) utilizing other sources of GF such as cells and plasma-rich plasma and plasma-rich fibrin. Summary GFs can promote reparative-dentinogenesis and pulp-like tissue formation. The future development and clinical approval of GF-functionalized-scaffolds is a priority; however, current focus should be to harness DMCs and target the interaction of stem cells and GFs.

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