Histological and histochemical changes in experimental manganese encephalopathy in rabbits

Chandra, Satya V.

doi:10.1007/bf00316512

Cited by 27 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of excellent reports dealing with metabolic alterations induced by the administration of ethanol or manganese along to the experimental animals have appeared in the literature (Israel & Hardone 1971 ;Mustafa & Chandra 1971 ;Chandra 1972;Singh et al 1974). Almost similar changes in the biological system have been observed in the present study when the metal or ethanol is administered alone to the rats.…”

Section: Discussionmentioning

confidence: 99%

The Interaction Between Manganese and Ethanol in Rats

Shukla

Singh

Chandra

1978

Acta Pharmacologica et Toxicologica

Self Cite

View full text Add to dashboard Cite

The effects of manganese and ethanol interaction on some chemical constituents of the liver and serum of rats were investigated in order to assess the influence of these substances in inducing susceptibility to manganese poisoning. Manganese and ethanol alone or in combination were administered to the rats as drinking solutions for a period of 30 days. Both the chemicals had a synergistic effect in altering the activity of SDH and ATPase in the liver of rats. The combined treatment also produced significant increase in the activity of adenosine deaminase and α‐amylase in the liver and serum respectively. Furthermore, the accumulation of manganese in the liver and the increase in the calcium content of the serum were significantly greater after combined ethanol and manganese administration – than either of them alone. These alterations indicate that the toxic effects of manganese are enhanced when the metal and ethanol interact in the biological system.

show abstract

Section: Discussionmentioning

confidence: 99%

The Interaction Between Manganese and Ethanol in Rats

Shukla

Singh

Chandra

1978

Acta Pharmacologica et Toxicologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lindahl, et al (1999) reported that astrocytes can accumulate lead up to 24 times more than neurons. Studies have also showed that astrocytes accumulated manganese by a high affinity, high capacity, and specific transport system (Chandra, 1972). These findings suggest that astrocytes may be an initial target for insult.…”

Section: Introductionmentioning

confidence: 90%

The protective role of chelators and antioxidants on mancozeb-induced toxicity in rat hippocampal astrocytes

Tsang

Trombetta

2007

Toxicol Ind Health

View full text Add to dashboard Cite

Mancozeb, manganese ethylene-bis-dithiocarbamate with zinc salts, is one of the most commonly used fungicides in the United States. Epidemiological and experimental data showed that mancozeb causes detrimental effects on various organ systems including the reproductive, endocrine, immune, and central nervous system. Increasing evidence has shown a strong association between pesticides and neurodegenerative diseases. In this study, we examined the neurotoxic potential of mancozeb in rat hippocampal astrocytes. The cytotoxicity of mancozeb was found to be dose dependent and recovery studies showed that cells exposed to mancozeb for 1 h did not recover from mancozeb-induced insult. Atomic absorption data showed a significant accumulation of manganese in astrocytes after 1 h of treatment. This study further investigated whether various chelators and antioxidants could prevent mancozeb-induced cytotoxicity. Our data reported that butylated hydroxytoluene (BHT) was the most effective agent in protecting against mancozeb insult. BHT also increased total cellular antioxidants of astrocytes after 1-h mancozeb exposure. In summary, this study reported for the first time that the manganese portion of mancozeb might be, at least in part, responsible for the toxicity. Mancozeb-induced cytotoxicity in astroyctes can be protected by BHT and that this antioxidant increased the total cellular antioxidant capacity.

show abstract

“…Manganese intoxication produces morphological changes in the central nervous system of experimental animals (Mella 1924;Pentschew et al 1963;Chandra 1972). It has also been observed that behavioural changes appear much earlier than the histological alterations after manganese exposure to the animals .…”

mentioning

confidence: 99%

Effect of Manganese on Synthesis of Brain Catecholamines in Growing Rats

Chandra

Shukla

1981

Acta Pharmacologica et Toxicologica

Self Cite

View full text Add to dashboard Cite

The effect of short‐term exposure of manganese on the synthesis of brain catecholamines in growing rats has been investigated by using two methods, 1) measuring the amount of conversion of 3,5‐3H‐tyrosine to 3H‐labelled dopamine and norepinephrine, and 2) measuring the rate of decline of endogenous dopamine and norepinephrine following inhibition of their synthesis with α‐methyl‐p‐tyrosine. The magnitude of conversion of 3,5‐3H‐tyrosine to 3H‐dopamine and 3H‐norepinephrine in the brain at 60 min after the administration of labelled amino acid to the manganese treated rats (1 mg MnCl2.4H2O/ml of water for 30 days) was significantly greater than observed in control rats. Manganese also increased turnover of dopamine and norepinephrine to a greater extent in the brains of treated animals.

show abstract

Histological and histochemical changes in experimental manganese encephalopathy in rabbits

Cited by 27 publications

References 16 publications

The Interaction Between Manganese and Ethanol in Rats

The Interaction Between Manganese and Ethanol in Rats

The protective role of chelators and antioxidants on mancozeb-induced toxicity in rat hippocampal astrocytes

Effect of Manganese on Synthesis of Brain Catecholamines in Growing Rats

Contact Info

Product

Resources

About