Histomorphological Spectrum of Central Nervous System Tumours- A Three-Year Retrospective Descriptive Study in a Tertiary Care Centre

Narmadha, R.; Dhanalakshmi, Samiappan; M, Priyadharshini; P, Rajesh Natraj A.; Subitha, Subitha; Padmavathi, S

doi:10.14260/jemds/2017/728

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…This amounted to a total of 50% cases. This was in concordance with a literature by Shrilakshmi et al [29], Gadgil NM et al [36], Patil, P. R et al [37], Raza AKMM et al [32], Jat KC et al [38], Narmadha R et al [39] and Samadi N.et al [40]. [26].…”

Section: Discussionsupporting

confidence: 90%

Clinicopathological study of Meningioma

Jansari

Patel

Chaudhari³

2020

Trop J Pathol Microbiol

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Introduction: Meningiomas are tumors that arise from the meningothelial cells. They are commonly located at intracranial, intraspinal or occasionally ectopic site. They show histological diversity and are categorized into three grades. This grading helps in predicting their behaviour and deciding treatment strategy. Aims and Objectives: To study the incidence, anatomical location, sex and age Predilection, histological variants and grading of meningiomas based on WHO 2016 classification. To correlate clinical features and radiological findings with those of histopathological findings. Materials and Methods: The study is carried out in the Department of Pathology, Dhiraj General Hospital, Piparia from November 2016 to July 2018. 30 tumors specimen diagnosed as meningioma by radiology and neurosurgery department, sent to department of pathology were included in the study. Analysis of histological features, typing and grading of all cases was done according to WHO 2016 classification of meningioma. Results: Total 30 meningioma tumors were included in the study. Most of them were intracranial, predominantly involving the posterior fossa of brain, females and the 41-60 age group. The most common histological subtype was psammomatous followed by meningothelial. Majority (93.33%) were benign grade I tumors. In 90% cases radiological diagnosis matched exactly with histopathological diagnosis. Conclusion: Meningiomas are slow growing tumors arising from the meningothelial cells accounting for 15-30 % of all CNS neoplasms showing a variety of histological patterns, more common in women, predominantly Grade I tumors. Recurrence of tumors depends on histological grade and extent of surgery.

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Section: Discussionsupporting

confidence: 90%

Clinicopathological study of Meningioma

Jansari

Patel

Chaudhari³

2020

Trop J Pathol Microbiol

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Trends in clinico-epidemiology profile of surgically operated glioma patients in a tertiary care center over 12 years—through the looking glass!

et al. 2021

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Background Hospital-based cancer registries can provide information on the magnitude and distribution of cancers in a given hospital. Hospital-based brain tumor registry data, focusing on glioma, from a tertiary care rural neurological center is lacking in the scientific literature. This data can be useful in understanding the need for research and funding required for these specific brain tumors. Data of patients operated for glioma, at our institute, was collected between January 2004 and December 2015. Patients’ clinical details and histopathological diagnosis were recorded. Data were analyzed and compared with that of previously published literature, and inferences were drawn on patterns of reporting and epidemiology. Results A total of 1450 cases of glioma, with a mean age of 39.3 (± 17.36 SD) years with males (66.6%) comprising more population as compared to females. Majority of patients 70.8% (n = 1027) belong to the economically active age group of country (18–60 years). Majority of cases (41.4%) were glioblastoma with the next common tumor (22.8%) being diffuse astrocytoma (n = 331) followed by pilocytic astrocytoma (6.2%) and oligodendroglioma (4.5%) in that order. While our data followed similar trends with other Indian data the average age of glioma was a decade younger to what is quoted earlier in Indian and international studies. Conclusion This data for glioma gives a glimpse of the prevalence of this tumor in a primarily rural population and highlights the need for a National Brain Tumor Registry with the need for the development of evidence-based policymaking and enhanced research into this particular ailment.

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An experience of Methylguanine-DNA Methylation Assay (MGMT) characterization in glial tumors

Kaler,

Thoma,

Suhas

et al. 2022

Journal of Precision Oncology

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Background: MGMT (O6-methylguanine DNA methyltransferase) is a DNA repair enzyme, that rescues tumor cells from damage by alkylating agents like temozolomide (TMZ). Promotor methylation of MGMT leads to epigenetic silencing and potentially increased sensitivity to TMZ. MGMT methylation (mMGMT) is an independent favorable prognostic factor, and has confounded its role as a predictive biomarker in making therapeutic decisions for glial tumors, particularly glioblastoma multiforme (GBM). Materials and Methods: This retrospective cross-sectional study was conducted for 5 years in high-grade tumors (HCG) Cancer Hospital between January 2016 and December 2020. Methylation-specific polymerase chain reaction of MGMT gene using bisulfite modification of tumor DNA was utilized to ascertain the methylation status of cases in the cohort. Results: A total of 54 glial tumors comprising 35 males and 18 females between the age group 11 years to 76 years underwent mMGMT testing. About 64.8% (35 cases) of all glial tumors demonstrated mMGMT in the cohort; GBM accounting for a majority of the cases (80.0%; 28 cases). The percentage of mMGMT cases in males and females was found to be 60.0% and 73.0% of cases, respectively. The confluent necrosis commonly seen in GBM is present in 41.0% of methylated cases and minimal in 77.3% of unmethylated cases with a significant P < 0.05. Conclusion: MMGMT is a valuable predictive biomarker and is essential in taking the therapeutic decision in newly diagnosed glial tumors. Necrosis can be used as an indicator of mMGMT status according to the present study.

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Histomorphological Spectrum of Central Nervous System Tumours- A Three-Year Retrospective Descriptive Study in a Tertiary Care Centre

Cited by 3 publications

References 15 publications

Clinicopathological study of Meningioma

Clinicopathological study of Meningioma

Trends in clinico-epidemiology profile of surgically operated glioma patients in a tertiary care center over 12 years—through the looking glass!

An experience of Methylguanine-DNA Methylation Assay (MGMT) characterization in glial tumors

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