Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Abstract

Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of these lesions increases with advancing age. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transurethral resection of prostate (TURP) is most frequently preformed surgical procedure in the clinical practice. The purpose of the study is to evaluate histomorphological spectrum of prostate lesions in TURP specimen with focus on premalignant lesions and incidental carcinomas.Methods: The present study includes 245 cases of TURP specimen from January 2015 to December 2016 received in the post graduate department of pathology, ASCOMS and Hospital. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies.Results: Of the total 245 TURP specimen, 223 (91.02%) were of nodular hyperplasia, 14 (5.71%) were of prostatic intraepithelial neoplasia and 8 (3.26%) cases were malignant. Benign hyperplasia of prostate (BHP) alone accounted for 91.02% of TURP specimen. Less frequent findings were granulomatous prostatitis in 3.70% and atypical adenomatous hyperplasia (1.22%). All the 8 cases of prostate cancer were incidental carcinoma, 5 of which were poorly differentiated and 3 were moderately differentiated adenocarcinoma.Conclusions: The present study showed that non-neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BHP, commonly seen in the age group of 61-70 years. The malignant lesions were common among the males of more than 60 years. TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.

Prostatic lesions: Histopathological study in a tertiary care hospital

“…The finding of HGPIN along with elevated serum PSA is an indication of repeat biopsy and follow up. 4,10,17 In our study 2(2.08%) cases showed HGPIN similar to the study by Sharma A et al 12 who have found 2.04% HGPIN in their studies. Our study showed 8(8.34%) of prostate carcinoma which was similar to other studies.…”

“…Benign lesions were common in the age group of 61-70 years whereas malignant lesions were common in the age group of 71-80 years which is in concordance with other studies. 8,11,12 Among the benign lesions nodular hyperplasia of prostate was the most frequent histo-pathological diagnosis in our study accounting for 89.58% cases. Bal et al 13 and Dawam et al 14 observed Nodular hyperplasia of prostate in 87% and 86% cases respectively which is similar to our study.…”

“…In our study 7 out of 8 carcinoma were incidental carcinoma which accounts for 7.29% of all cases. Sharma et al 12 found all prostate carcinoma as incidental carcinoma in their study. Dellavedova T et al 21 reviewed 100 TURP specimens and found incidental cancer detection rate of 7% similar to our study.…”

“…Patel SK et al 11 and Josephine A 15 have reported chronic prostatitis associated with nodular hyperplasia of prostate in 26.78% and 25.31% cases respectively. Sharma A et al 12 found prostatitis in 33.06% cases of Nodular hyperplasia of prostate out of which 86.42% cases were chronic non-specific prostatitis, 9.88% were acute prostatitis and 3.7% were granulomatous prostatitis. Squamous metaplasia associated with nodular hyperplasia of prostate was seen in 1(1.04%) case in the current study.…”

Spectrum of Prostatic Lesions in a Tertiary Care Hospital- A 5½-Year Retrospective Descriptive Study

“…2018;7(36):3991-3995, DOI: 10.14260/jemds/2018/891 BACKGROUND Prostate is one of the most commonly affected organs in males. 1 The incidence of prostatic lesions increases with increasing age. 2,3 The most important diseases of prostate are inflammatory lesions (Prostatitis), nodular hyperplasia (Benign prostatic hyperplasia) and carcinoma.…”