Histopathological characteristics of female breast carcinomas seen at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Gogo-Abite, M; Nwosu, SO

doi:10.4314/njm.v14i1.37139

Cited by 5 publications

(6 citation statements)

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“…who reported prevalent Grade II tumors. This finding, however, contrasts with the reported predominance of Grade III cancers by Gogo-Abite et al [22]. and Bewtra [19], and the findings by Imam et al 28 who reported Grade I tumors as the majority in their study.…”

Section: Resultscontrasting

confidence: 75%

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria; A 9-year Review

Biswas¹

2022

JSPC

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Background: The breast is affected by several diseases, including developmental, inflammatory, and neoplastic. While benign breast neoplasms are usually more common, breast cancer is the most common nonskin cancer and the leading cause of cancer-related deaths in women after lung cancer in the world. Objective: The review aimed to assess the histopathological diagnosis of breast lesions over a period of 9years Methods: This was a retrospective review of eight hundred and fourteen histopathologic cases of breast lesions accessed through laboratory records of all breast lesions cases seen. The demographic data were obtained and the patient’s histology slides were reviewed. The tumors were classified according to the WHO International Classification of breast tumors and Malignant breast tumors were graded according to the Nottingham grading system. Data were analyzed using SPSS version 25. Results: The majority of breast cancer cases were seen in patients below 40 years, malignant cases were predominant in older age groups (40 – 59 years; 57.4%, 60 years and above; 23.3%) and malignancy was significantly associated with age group, p-value < 0.05. The prevailing neoplasm was Benign type (68.3%) while malignant neoplasm accounted for 30.2% and invasive ductal carcinoma (89.1%) was most prevalent. Moreso, the majority were in grade 2; 152 (76.8%) using the Nottigham grading system. However, the commonest benign neoplasm was fibroadenoma (53.7%) followed by fibrocystic change (20.1%). Conclusion: Breast lesions are common in this environment. Benign breast neoplasms are commoner than malignant diseases. One in three of every sub-Saharan woman diagnosed with malignant breast lesion may not survive five years post-diagnosis. The prognosis of breast malignancies in sub-Saharan is poor due to late Presentation, ignorance and poverty.

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Section: Resultscontrasting

confidence: 75%

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria; A 9-year Review

Biswas¹

2022

JSPC

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“…The higher rates reported by Nwafor and Udo, in Uyo (44.3%), [10] Ogbuanya et al, in Abakaliki (43.7%), [13] and Eke et al, in Makurdi (43.6%) [7] are in the minority, and the reason is not immediately apparent. Irabor et al [21] documented an unusually low proportion of 10.6%. This may be due to the design of their study which examined only breast lumps from an arm of their general surgery unit.…”

Section: Discussionmentioning

confidence: 94%

“…Comparative to the rate of 3.3% reported in Calabar [20] and 2.3% in Abakaliki, [13] it is noteworthy that proliferative lesions (intraductal papilloma, atypical ductal hyperplasia sclerosing adenosis, and flat epithelial hyperplasia) in this study comprised 2.1% of BBNs. These lesions are believed to carry a relative risk for developing invasive breast carcinoma of 1.5% to 2% [2,21].…”

Section: Discussionmentioning

confidence: 99%

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria: A 9-year Review

Ayo-Aderibigbe

Oloyede²,

Adekunle

et al. 2022

JCTI

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Background: The breast is affected by several diseases, including developmental, inflammatory, and neoplastic. While benign breast neoplasms are usually more common, breast cancer is the most common nonskin cancer and the leading cause of cancer-related deaths in women after lung cancer in the world. Objective: The review aimed to assess the histopathological diagnosis of breast lesions over a period of 9years Methods: This was a retrospective review of eight hundred and fourteen histopathologic cases of breast lesions accessed through laboratory records of all breast lesions cases seen. The demographic data were obtained and the patient’s histology slides were reviewed. The tumors were classified according to the WHO International Classification of breast tumors and Malignant breast tumors were graded according to the Nottingham grading system. Data were analyzed using SPSS version 25. Results: The majority of breast cancer cases were seen in patients below 40 years, malignant cases were predominant in older age groups (40 – 59 years; 57.4%, 60 years and above; 23.3%) and malignancy was significantly associated with age group, p-value < 0.05. The prevailing neoplasm was Benign type (68.3%) while malignant neoplasm accounted for 30.2% and invasive ductal carcinoma (89.1%) was most prevalent. Moreso, the majority were in grade 2; 152 (76.8%) using the Nottigham grading system. However, the commonest benign neoplasm was fibroadenoma (53.7%) followed by fibrocystic change (20.1%). Conclusion: Breast lesions are common in this environment. Benign breast neoplasms are more commoner than malignant diseases. One in three of every sub-Saharan woman diagnosed with malignant breast lesion may not survive five years post-diagnosis. The prognosis of breast malignancies in sub-Saharan is poor due to late Presentation, ignorance, and poverty.

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“…Aggressive breast cancer, has an early onset, a high proliferation ratio, poor host cellular immune reaction, high grade, is node positive, hormone receptor-negative, and has a poor prognosis for survival (Gogo-Abite and Nwosu, 2005;Fregene and Newman, 2005). These clinical characteristics are relatively similar for many African and African American women and their frequency serves to distinguish these women from their European American compatriots.…”

Section: Local Ancestral Foundersmentioning

confidence: 99%

Ancestral links of Chesapeake Bay region African Americans to specific Bight of Bonny (West Africa) microethnic groups and increased frequency of aggressive breast cancer in both regions

Jackson

2008

American J Hum Biol

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The high frequency of aggressive, early onset, and highly fatal breast cancer among Chesapeake Bay region African Americans suggests that there may be a contributing ancestral component. This study identifies the region's founding African, European, and Native American Indian populations using ethnogenetic layering and identifies the microethnic substructure of each founding continental aggregate. The largest component (38%) of the enslaved Africans brought to the Chesapeake Bay originally came from the coastal and hinterlands of the Bight of Bonny, a region with very high rates of aggressive, early onset breast cancer. Ethnogenetic layering is applied a second time to reveal the microethnic groups of the Bight of Bonny hinterlands with historical links to the Chesapeake Bay region. These analyses identify the specific microethnic groups within this region of Africa that may be the sources of relevant polymorphisms contributing to the etiology of aggressive breast cancer in the Chesapeake Bay. This report suggests a historical link between specific African microethnic groups and a US health disparity.

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Histopathological characteristics of female breast carcinomas seen at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Cited by 5 publications

References 0 publications

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria; A 9-year Review

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria; A 9-year Review

Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria: A 9-year Review

Ancestral links of Chesapeake Bay region African Americans to specific Bight of Bonny (West Africa) microethnic groups and increased frequency of aggressive breast cancer in both regions

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