Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats

Abstract

Fluorides have been a cause of concern for scientists and environmentalists for the long because of their harmful effects on the human and animal life but the problem was highlighted during the twentieth century because of great increase in the human population and industrialization. Since fluorides accumulate in calcified and hard tissues of the body such as bone and teeth and can be detected easily in these tissues, so most of the previous studies focused on the effects of fluorides on these tissues. However, during the past decade researchers all over the world have felt that there is a need to study the effects of fluorides on various other tissues of the body including CNS as fluoride intake for prolonged period is known to cause abnormal behavioural pattern, grave implications for Alzheimer’s Disease, Dementia, Attention deficit disorder and reduced I.Q in children as the fluorides are known to cross blood brain barrier. Hence the present study has thrown light on the involvement of brain in chronic fluoride toxicity. The target organ of studied was cerebrum. In the Study, albino rats were exposed to 30 or 100 ppm fluoride (asNaF) in drinking water for 3 months. Rats exposed to 30 ppm fluoride did not show any notable alterations in brain histology, whereas rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in lhe motor cortex.Changes included decrease in size and number of neurons in all the regions, signs of chromatolysis and gliosis in the motor cortex. These histological changes suggest a toxic effect of high-fluoride intake & on chronic use. [J Interdiscipl Histopathol 2012; 1(1.000): 30-34

Effect of sodium fluoride on the grey matter of spinal cord in the albino rat and the protective role of green tea extract

“…However, during the past decade researchers all over the world have felt that there is a need to study the effects of fluorides on other tissues of the body including central nervous system, as the fluorides are known to cross blood brain barrier. [21] In the present study, the animals of negative control subgroup showed a significant increase in the body weight at the end of the experiment. This was in agreement with Soliman et al [18] who reported that balanced diet feeding resulted in a significant increase in the body weight of rats.…”

Neurotoxicity induced by Fluoride in Rat Cerebral Cortex

“…Some pyramidal neurons showed chromatolysis (Trivedi et al, 2012), and were shrunken with vacuolation around them. These results are in accord with the results of Ge et al(2005), Fattah et al, (2010), Hamid et al, (2012 and Shashi and Sharma (2015), who documented distinct morphological alterations in the brain including effects on neurons of the cerebrum. In other study on amygdala, motor cortex, cerebellum, hippocampus (Shivarajashankara et al, 2002), and the cerebrovascular integrity after chronic administrations of sodium fluoride or aluminum fluoride (Varner et al, 1998) comparable results was obtained.…”