Histopathological features of intra-ductal carcinoma of prostatic and high grade prostatic intraepithelialneoplasia and correlation with PTEN and P63

Torabinezhad, S; Malekmakan, Leila; Mashayekhi, Mohadese; Daneshian, Arghavan

doi:10.1002/pros.23130

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…With PTEN loss in two third of the cases, the concordance between IDC-P and adjacent carcinoma was 81% [69]. PTEN loss has also been observed in almost 90% of 40 IDC-P cases compared to 0% of 40 HGPIN cases [77]. Downes et al [74] further verified the concordance of ERG and PTEN expression patterns in IDC-P, CC and the adjacent invasive carcinoma in a cohort of 57 PCa cases with cribriform morphology.…”

Section: Pten and Erg (Tmprss2:erg)mentioning

confidence: 90%

“…Contrary to PTEN, TM-PRSS2:ERG fusion or ERG expression has not been clearly linked to PCa outcome and is mostly used as a diagnostic marker [93][94][95][96][97]. Since the expression of ERG and PTEN can be evaluated by IHC, a very accessible histopathology technique, these two markers are the most studied in IDC-P [66][67][68][69][70][71][72][74][75][76][77][78]98].…”

Section: Pten and Erg (Tmprss2:erg)mentioning

confidence: 99%

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Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

Pantazopoulos

Diop

Grosset

et al. 2022

Cancers

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Intraductal carcinoma of the prostate (IDC-P) is one of the most aggressive types of prostate cancer (PCa). IDC-P is identified in approximately 20% of PCa patients and is associated with recurrence, metastasis, and PCa-specific death. The main feature of this histological variant is the colonization of benign glands by PCa cells. Although IDC-P is a well-recognized independent parameter for metastasis, mechanisms by which IDC-P cells can spread and colonize other tissues are not fully known. In this review, we discuss the molecular portraits of IDC-P determined by immunohistochemistry and genomic approaches and highlight the areas in which more research is needed.

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Section: Pten and Erg (Tmprss2:erg)mentioning

confidence: 90%

Section: Pten and Erg (Tmprss2:erg)mentioning

confidence: 99%

Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

Pantazopoulos

Diop

Grosset

et al. 2022

Cancers

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“…Although the biological nature of IDC‐P is an enigma, recent studies have indicated that the IDC‐P component is endowed with resistance to androgen deprivation therapy (ADT) and a high invasive capacity. In addition, several studies have shown that PTEN loss is more enriched in IDC‐P components than in ordinary invasive PCa 7–14 . PTEN is a tumor suppressor and one of the most frequently genetically altered genes in advanced PCa 15 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, several studies have shown that PTEN loss is more enriched in IDC-P components than in ordinary invasive PCa. [7][8][9][10][11][12][13][14] PTEN is a tumor suppressor and one of the most frequently genetically altered genes in advanced PCa. 15 PTEN loss has also been shown to induce resistance to ADT combined with TP53 and/or Rb alterations.…”

Section: Introductionmentioning

confidence: 99%

PTEN loss in intraductal carcinoma of the prostate has low incidence in Japanese patients

Ito,

Takahara,

Taniguchi

et al. 2023

Pathology International

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Clinical and genomic features of prostate cancer (PCa) vary considerably between Asian and Western populations. PTEN loss is the most frequent abnormality in intraductal carcinoma of the prostate (IDC‐P) in Western populations. However, its prevalence and significance in Asian populations have not yet been well studied. In the present study, we evaluated PTEN expression in IDC‐P in a Japanese population and its association with ERG expression. This study included 45 and 59 patients with PCa with and without IDC‐P, respectively, who underwent radical prostatectomy. PTEN loss was observed in 10 patients with PCa with IDC‐P (22%) and nine patients with PCa without IDC‐P (17%). ERG expression was relatively frequent in patients with PCa with PTEN loss, although a significant difference was not observed. The co‐occurrence of PTEN loss and ERG expression was observed in four patients with PCa with IDC‐P and one without IDC‐P. PTEN loss and ERG expression did not affect progression‐free survival, regardless of the presence of IDC‐P. The frequency of PTEN loss in IDC‐P is lower in Asian patients than in Western patients. Our results indicate that mechanisms underlying IDC‐P in Asian populations are different from those of Western populations.

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Foamy gland high-grade prostatic intraepithelial neoplasia on core biopsy and subsequent radical prostatectomy: An in depth case report of a rare variant

Friedman

Costa

Kapur

2017

Human Pathology: Case Reports

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Histopathological features of intra-ductal carcinoma of prostatic and high grade prostatic intraepithelialneoplasia and correlation with PTEN and P63

Abstract: We found that IDC-P had a unique histoclinical feature and was strongly associated with poor prognostic factors. Diagnosis and report of IDC-P should be considered in all prostate specimens. Also, we recommend PTEN IHC application for differentiated IDC-P from HGPIN in biopsies.

Cited by 8 publications

References 28 publications

Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

PTEN loss in intraductal carcinoma of the prostate has low incidence in Japanese patients

Foamy gland high-grade prostatic intraepithelial neoplasia on core biopsy and subsequent radical prostatectomy: An in depth case report of a rare variant

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