The acrylic cage showed significantly higher mechanical stiffness and less subsidence than bone grafting. Additional studies with more subjects and longer follow-up periods are needed to compare the cost effectiveness of acrylic cages and polyetheretherketone devices.

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We found that IDC-P had a unique histoclinical feature and was strongly associated with poor prognostic factors. Diagnosis and report of IDC-P should be considered in all prostate specimens. Also, we recommend PTEN IHC application for differentiated IDC-P from HGPIN in biopsies.

Cytomegalovirus infection (CMV) is a well-known consequence of immunosuppression and one of the expected pathogens in recipients of solid organs such as renal transplant recipients (RTRs). Infection by CMV in immunocompromised settings can be life-threatening since many organs are involved and affected. Skin involvement has been rarely reported. In this report, we present a highly immunosuppressed RTR with CMV infection manifested as ulcerative skin lesions on the face, along with allograft dysfunction diagnosed by biopsy of the skin and the renal allograft, in addition to the presence of viral DNA in the tissue and antigenemia, which resolved following antiviral treatment. To the best of our knowledge, this is the first report in the literature of facial skin involvement induced by CMV in an RTR. This report emphasizes the value of early biopsy in RTRs with skin lesions and highlights CMV infection as a possible etiology.

Background: Several studies reported that endometriosis is associated with an increased risk of ovarian cancer. Atypical endometriosis is common in patients with endometriosis-associated ovarian, which might be considered as a precancerous lesion. Objectives: This study aimed to assess ki67 and PTEN expression in endometriosis associated ovarian cancer (EAOC), atypical endometriosis, and typical endometriosis. Methods: In this study, all H & E slides of 260 ovarian endometriosis cases were reviewed. And 25 cases were diagnosed with atypical endometriosis. Forty-one typical endometrioses and 24 ovarian cancers with endometriosis were included. We assessed PTEN and Ki67 immunoexpression in epithelial and stromal cells. Results: The prevalence of atypical endometriosis was about 9%. PTEN loss was found in 12 (out of 24 or 50%) of EAOC, 2 (out of 25; 8%) of atypical endometriosis, and none of the typical endometriosis. In all 12 PTEN loss cases, the PTEN loss pattern in endometriosis adjacent to ovarian cancer was similar to that of ovarian cancer. A total of 7.3% of typical endometriosis and 8% atypical endometriosis and 33.3% of EAOC had Ki67 staining in more than 50% of the epithelial component. Both typical and atypical endometriosis showed similar PTEN loss and Ki 67 staining (in more than 50% of the epithelial component) (P value > 0.05), and both of them were different from EAOC (P value < 0.05). Conclusions: The PTEN loss pattern in endometriosis adjacent to ovarian cancer was similar to that of ovarian cancer. The result indicated that PTEN loss could be an early event in the tumor development pathway from endometriosis to ovarian cancer.