Histopathological spectrum of 364 prostatic specimens including immunohistochemistry with special reference to grey zone lesions

Garg, Monika; Kaur, Gurmeen; Malhotra, Vineeta; Rk, Garg

doi:10.12954/pi.13026

Cited by 20 publications

(23 citation statements)

References 14 publications

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“…There was no significant difference in the mean age between patients with benign and malignant lesions (p value 0.27). This finding is in agreement with the study by Garg M et al 7 . Benign lesions were common in the age group of 61-70 years whereas malignant lesions were common in the age group of 71-80 years which is in concordance with other studies.…”

Section: Discussionsupporting

confidence: 94%

“…Although tools such as trans-rectal ultrasound, prostate specific antigen (PSA) are used for screening of prostate cancer, biopsy still remains the gold standard for final diagnosis. 7 In our study most of the specimens received were TURP (88.54%), which was similar to other studies. 8,9 This could be due to the fact that TURP is a preferred surgery for nodular hyperplasia of prostate as it is a simple procedure with fewer complications.…”

Section: Discussionsupporting

confidence: 91%

“…Metaplasia in nodular hyperplasia of prostate is usually secondary to inflammation or injury. Garg M et al 7 and Abdollahi A et al 16 observed squamous metaplasia in 0.8% and 0.3% cases in their studies.…”

Section: Discussionmentioning

confidence: 75%

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Prostatic lesions: Histopathological study in a tertiary care hospital

Bhatta

Hirachan

2018

J. Manmohan Memorial Inst. Health. Sci.

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Background: Prostatic lesions like Nodular hyperplasia of prostate, inflammation and carcinoma are common causes of morbidity and mortality in males. The incidence of these lesions increases with age. This study was conducted with the objective of evaluating histopathological pattern of prostatic lesions.Methods: This was a retrospective study conducted at KIST Medical College from Jan 2014 to Jan 2018. The study included ninety six prostatic specimens received in department of pathology. Hematoxylin and Eosin stained slides were retrieved and reviewed. The specimens and slides were analyzed according to type of specimen, age of patient, histopathological pattern and final diagnosis. Results were analyzed using Statistical Package for Social Science (SPSS, version 21) for Windows. Independent t test was used to correlate the mean age between patients with benign and malignant lesions. P value less than 0.05 was considered as statistically significant.Results: The most common benign lesion was nodular hyperplasia of prostate 86(89.58%). Malignant lesions comprised 8 (8.34%) cases of all prostatic lesions. All the cases of prostate carcinoma were adenocarcinoma. The most frequent Gleason score was 9. Mean age for benign and malignant lesions were 69.6 ± 8.1 years and 72.9 ± 5.2 years respectively. There was no significant difference in the mean age between patients with benign and malignant lesions (p value 0.27).Conclusion: Benign lesions of prostate are more common than malignant lesions. Histopathological examination of prostate specimens have important role in diagnosing various benign and malignant lesions, especially to rule out incidental carcinoma.JMMIHS.2018;4(1):12-19

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

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Prostatic lesions: Histopathological study in a tertiary care hospital

Bhatta

Hirachan

2018

J. Manmohan Memorial Inst. Health. Sci.

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“…3,24 The incidence of AAH in our research was noted to be 1.22% which correlates with the findings reported by Puttaswamy K et al (2%) and Garg et al (1.65%). 21,25 PIN is defined as a cytological alteration in architecturally normal glands. Currently, it is grouped into two categories: LGPIN and HGPIN.…”

Section: Discussionmentioning

confidence: 99%

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

Sharma

Gandhi

et al. 2017

Int J Res Med Sci

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Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of these lesions increases with advancing age. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transurethral resection of prostate (TURP) is most frequently preformed surgical procedure in the clinical practice. The purpose of the study is to evaluate histomorphological spectrum of prostate lesions in TURP specimen with focus on premalignant lesions and incidental carcinomas.Methods: The present study includes 245 cases of TURP specimen from January 2015 to December 2016 received in the post graduate department of pathology, ASCOMS and Hospital. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies.Results: Of the total 245 TURP specimen, 223 (91.02%) were of nodular hyperplasia, 14 (5.71%) were of prostatic intraepithelial neoplasia and 8 (3.26%) cases were malignant. Benign hyperplasia of prostate (BHP) alone accounted for 91.02% of TURP specimen. Less frequent findings were granulomatous prostatitis in 3.70% and atypical adenomatous hyperplasia (1.22%). All the 8 cases of prostate cancer were incidental carcinoma, 5 of which were poorly differentiated and 3 were moderately differentiated adenocarcinoma.Conclusions: The present study showed that non-neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BHP, commonly seen in the age group of 61-70 years. The malignant lesions were common among the males of more than 60 years. TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.

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“…Carcinoma of prostate is most common internal malignancy among men in United State and is responsible for 10% of cancer deaths 5 .In India, prostate cancers constitute about 5% of all cancers in male 5,6 . Screening of prostatic lesions constitute prostate specific antigen, digital rectal examination, and transrectal ultrasound, but biopsy remains the gold standard diagnostic tool for final diagnosis.…”

Section: Introductionmentioning

confidence: 99%

"Study of Various Histopathological Patterns in Prostate Biopsy"

2017

IJCRR

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Introduction: Diseases of prostate gland are important source of morbidity and mortality in male patients. The spectrum of diseases consists of inflammatory conditions, nodular hyperplasia, malignancy etc. The risk of diseases increases with age. Prostate biopsy is essentially a test which detects cancer and other benign conditions of the prostate in patients who have specific indications for it. Other modalities of diagnosis also have been developed, comprising of radiological modalities and prostatic biomarkers. However, biopsy with histopathological examination is the gold standard for the final diagnosis.

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Histopathological spectrum of 364 prostatic specimens including immunohistochemistry with special reference to grey zone lesions

Cited by 20 publications

References 14 publications

Prostatic lesions: Histopathological study in a tertiary care hospital

Prostatic lesions: Histopathological study in a tertiary care hospital

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

"Study of Various Histopathological Patterns in Prostate Biopsy"

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