Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk

Casas-Bedoya, Alvaro; Garay, Jone; Sanzòn, Fernando; Bravo, Luis Eduardo; Bravo, Juan Carlos; Correa, Hernán; Craver, Randall; Fontham, Elizabeth; Du, Joanna X.; Correa, Pelayo

doi:10.1053/hupa.2003.43

Cited by 39 publications

(47 citation statements)

References 19 publications

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“…Enhanced macrophage infiltration in gastric mucosa of H. pylori-infected children has also been observed in other studies, where CD68 or KP-1 was used as cell markers [31][32][33]. When, however, CD14-staining was carried out, this association was not so evident [34,35].…”

Section: Discussionmentioning

confidence: 50%

Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression

Dzierżanowska-Fangrat

Michałkiewicz²,

Cielecka-Kuszyk³

et al. 2008

European Journal of Gastroenterology & Hepatology

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Section: Discussionmentioning

confidence: 50%

Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression

Dzierżanowska-Fangrat

Michałkiewicz²,

Cielecka-Kuszyk³

et al. 2008

European Journal of Gastroenterology & Hepatology

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“…The mild intensity of the inflammatory response occurs despite variations in the prevalence of H. pylori infection among different ethnic groups and geographic regions. In Columbia, Bedoya and colleagues [4] found a high H. pylori infection prevalence linked to an intense inflammatory response. The current study showed a significant difference between its study populations and the one in Colombia.…”

Section: Discussionmentioning

confidence: 98%

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Jaramillo-Rodríguez

Nares-Cisneros²,

Martínez-Ordaz³

et al. 2011

Pediatr Dev Pathol

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The objective of this study was to analyze the histopathological patterns of inflammation, distribution, severity, and degree of gastric mucosa of Helicobacter pylori (Hp)-infected children in Northern Mexico, as well as the correlation between colonization density and inflammation intensity. We carried out a cross-sectional study of gastric biopsies performed on children ranging from 2 to 17 years of age who underwent upper gastrointestinal endoscopy for diverse gastroduodenal disorders. This study includes only children who were found to be Hp carriers, with positive results for tests of Hp antigens in feces and in gastric biopsy studies. We studied 107 patients (age 8.2 ± 3.7 years). In 47.7% of patients, the density of Hp colonization was low; only 21.5% had a marked density. Mononuclear leukocyte infiltration showed a similar distribution. Thirty-seven percent of patients had follicular gastritis. An acute inflammatory response was absent in 65% and mild in 20.6% of patients. When inflammation was present, it was primarily located in the antrum (79%). There were no cases of intestinal metaplasia or atrophy. A link was found between Hp density and age, infiltration by mononuclear cells, the presence of follicular gastritis, and the level of neutrophil infiltration (P = 0.001). Despite the high rates of Hp infection in the region, the histopathological findings in these children were mild and were limited primarily to the antral mucosa. These data indicate the need to study the behavior of this disease in children in diverse study populations to provide localized prevention and treatment strategies.

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“…Em pacientes adultos, tem-se evidenciado predomínio de infiltrado polimorfonuclear 25 , enquanto que, em crianças, o infiltrado inflamatório é geralmente mais crônico, com um número significativamente maior de células linfoplasmocitárias em relação ao de células polimorfonucleares 21 . Porém, os achados histológicos em crianças infectadas não são uniformes, parecendo depender da condição socioeconômica 26 .…”

Section: Discussionunclassified

Clinical and histological features of duodenal ulcer in children and adolescents

Kawakami¹,

Machado²,

Fonseca³

et al. 2004

J Pediatr (Rio J)

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Objective: To evaluate clinical and histological features of duodenal ulcer in children and adolescents.Methods: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6 year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection.Results: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/43, 74 ResumoObjetivo: Avaliar as características clínicas e histológicas de crianças e adolescentes com úlcera duodenal.Métodos: Foram avaliadas prospectiva e consecutivamente 43 pacientes com úlcera duodenal ao longo de 6 anos (7,2 pacientes por ano). A avaliação consistiu de questionário clínico de sintomas dispép-ticos, exame físico e endoscopia digestiva com biópsias gástricas para exame histológico e detecção do Helicobacter pylori.Resultados: A idade no diagnóstico variou de 4 anos e 8 meses a 17 anos e 4 meses (mediana = 12 anos e 4 meses ARTIGO ORIGINALGastrite crônica associada à infecção por Helicobacter pylori está presente na grande maioria das crianças com úlcera duodenal primária, havendo consenso para o tratamento de erradicação da bactéria, pela diminuição acentuada do índice de recidivas ulcerosas 1 . A colonização da mucosa gástrica por H. pylori, bacilo gram-negativo, microaerofílico, espiralado, atualmente ocorre em uma minoria das crianças de países desenvolvidos, ao contrário das crianças de países em desenvolvimento, sendo a prevalên-cia até 10 anos de idade de 5-10% e até 80%, respectivamente 2 . Os principais fatores de risco para contrair a infecção são: viver em país em desenvolvimento e ser criança com pais infectados e de baixo poder aquisitivo 3 . A maioria dos pacientes é assintomática, estimando-se que cerca de 15% evoluem para úlcera péptica e 1% para câncer gástrico 4 . Após a instalação da gastrite, a bactéria geralmente persiste por toda a vida, sendo rara a erradicação espontânea. Não há conclusão definitiva a respeito da influência dos fatores de virulência da bactéria, assim como da resposta do hospedeiro ou das condições ambientais que poderiam interferir no curso evolutivo desta afecção.

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Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk

Cited by 39 publications

References 19 publications

Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression

Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Clinical and histological features of duodenal ulcer in children and adolescents

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