Historical Medical Value of Donguibogam

Song, Bong‐Keun; Won, Jin-Hee; Kim, Sung‐Chul

doi:10.3831/kpi.2016.19.002

Cited by 32 publications

(20 citation statements)

References 2 publications

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“…Bangpungtongsung-san (BTS) is a traditional Korean medicine described in the Donguibogam, a well-documented textbook of traditional Korean medicine (Jun, 1980;Song et al, 2016). It was discovered while searching for a prescription for depression and comorbid diseases and acts as a 5-hydroxytryptamine (5-HT) 2C antagonist in 5-HT 2C receptor binding assays of our screening test.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

Park

Kim

et al. 2020

Front. Pharmacol.

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Bangpungtongsung-san (BTS) is a traditional Korean medicine consisting of 18 herbs, some which have antidepressant effects. Here, we used an animal model of reserpineinduced depression and lipopolysaccharide (LPS)-stimulated BV2 microglia to assess the antidepressant and anti-neuroinflammatory effects of BTS. Aside from a control group, C57BL/6 mice were administered reserpine (0.5 mg/kg) daily for 10 days via intraperitoneal injection. BTS (100, 300, or 500 mg/kg), vehicle (PBS), or fluoxetine (FXT, 20 mg/kg) was administered orally 1 h before reserpine treatment. Following treatment, a forced swimming test (FST), tail suspension test (TST), and open field test (OFT) were performed, and immobility time and total travel distance were measured. Administration of BTS not only reduced immobility time in the FST and TST but also significantly increased the total travel distance in the OFT. Furthermore, reserpine-treated mice showed significantly elevated serum levels of corticosterone, a stress hormone; however, treatment with BTS significantly reduced corticosterone levels, similar to FXT treatment. Serotonin in reserpine-treated mice was significantly reduced compared to that in control mice, while BTS mice exhibited increased serotonin levels. BTS mice showed increased expression of brain-derived neurotrophic factor (BDNF) and a higher ratio of phosphorylated cAMP response element-binding protein (p-CREB) to CREB (p-CREB/ CREB) in the hippocampus. Additionally, reserpine-treated mice exhibited significantly elevated mRNA levels of pro-inflammatory cytokines, but BTS mice showed reduced mRNA levels of interleukin (IL)-1b, IL-6, and tumor necrosis factor (TNF)-a in the hippocampus. To further demonstrate the anti-neuroinflammatory effects of BTS in vitro, we examined its anti-neuroinflammatory and neuroprotective effects in lipopolysaccharide (LPS)-stimulated BV2 microglia. BTS significantly reduced the levels of NO, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, TNF-a, IL-1b, and IL-6 in a dose-dependent manner via a decrease in the expression of nuclear factor (NF)-kB p65. Furthermore, the neuroprotective factor heme oxygenase-1 (HO-1) was upregulated via the nuclear factor-E2-related factor 2 (NRF2)/CREB pathway. Taken

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Section: Introductionmentioning

confidence: 99%

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

Park

Kim

et al. 2020

Front. Pharmacol.

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“…According to the original text of the Dongeuibogam, an encyclopedia of Oriental medical knowledge and techniques ( Song et al, 2016 ), the recipe for SJH should be subjected to natural fermentation to exert adequate medicinal effects based on its theory of orientalism (Yin/Yang theory) ( Heo, 1999 ). Based on the information and rationale mentioned above, we speculated that natural fermentation could improve the beneficial pharmacological properties of SJH, including hepatoprotective activities, and thereby potentiate the protective effects of this herb against HS as well.…”

Section: Introductionmentioning

confidence: 99%

A Controlled Fermented Samjunghwan Herbal Formula Ameliorates Non-alcoholic Hepatosteatosis in HepG2 Cells and OLETF Rats

Ansari

Bose²,

Patra

et al. 2018

Front. Pharmacol.

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Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against a number of metabolic diseases, including obesity. Herbal drugs, enriched with numerous bioactive substances, possess health-protective benefits. Meanwhile, fermented herbal products enriched with probiotics are known to improve metabolic processes. Additionally, current lines of evidence indicate that probiotics-derived metabolites, termed as postbiotics, produce the same beneficial effects as their precursors. Herein, the anti-HS effects of 5-weeks naturally fermented SJH (FSJH) was investigated with FSJH-mixed chow diet in vivo using Otsuka Long-Evans Tokushima Fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats as animal models of HS and controls, respectively. In parallel, the anti-HS effects of postbiotic-metabolites of three bacterial strains [Lactobacillus brevis (LBB), Lactococcus lactis (LCL) and Lactobacillus plantarum (LBP)] isolated from FSJH were also evaluated in vitro using the FFAs-induced HepG2 cells. Feeding OLETF rats with FSJH-diet effectively reduced body, liver, and visceral adipose tissue (VAT) weights, produced marked hypolipidemic effects on serum and hepatic lipid parameters, decreased serum AST and ALT levels, and upregulated the HMGCOR, SREBP, and ACC, and downregulated the AMPK and LDLR gene expressions levels. Additionally, exposure of FFAs-induced HepG2 cells to postbiotic metabolic media (PMM) of bacterial strains also produced marked hypolipidemic effects on intracellular lipid contents and significantly unregulated the HMGCOR, SREBP, and ACC, and downregulated the AMPK and LDLR genes expressions levels. Overall, our results indicate that FSJH enriched with fermented metabolites could be an effective anti-HS formulation.

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“…Various insect components, such as their bodies, eggs, egg shells, cocoons, exuviae, secretions, and toxins, have been used in traditional medicine [3]. The nymphal exuviae of the cicada are common insect-derived medicine; they are included in the ancient Korean medical book Dongui Bogam by Jun Heo [5]. In the Korean Herbal Pharmacopoeia, the exuviae of Cryptotympana dubia (Haupt, 1917) or Cryptotympana pustulata (Fabricius, 1787) are referred to as cicadidae periostracum (CP; sun-tae in Korean and chantui in Chinese) [6,7].…”

Section: Introductionmentioning

confidence: 99%

Rapid and Simple Species Identification of Cicada Exuviae Using COI-Based SCAR Assay

Noh

Kim

Song

et al. 2020

Insects

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Cicadidae periostracum (CP), the medicinal name of cicada exuviae, is well-known insect-derived traditional medicine with various pharmacological effects, e.g., anticonvulsive, anti-inflammatory, antitussive, and anticancer effects; it is also beneficial for the treatment of Parkinson’s disease. For appropriate CP application, accurate species identification is essential. The Korean pharmacopoeia and the pharmacopoeia of the People’s Republic of China define Cryptotympana atrata as the only authentic source of CP. Species identification of commercially distributed CP based on morphological features, however, is difficult because of the combined packaging of many cicada exuviae in markets, damage during distribution, and processing into powder form. DNA-based molecular markers are an excellent alternative to morphological detection. In this study, the mitochondrial cytochrome c oxidase subunit I sequences of C. atrata, Meimuna opalifera, Platypleura kaempferi, and Hyalessa maculaticollis were analyzed. On the basis of sequence alignments, we developed sequence-characterized amplified-region (SCAR) markers for efficient species identification. These markers successfully discriminated C. atrata from the three other cicada species, and detected the adulteration of market CP samples. This SCAR assay is a rapid, simple, cheap, reliable, and reproducible method for species identification, regardless of sample form and status, and contributes to CP quality control.

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Historical Medical Value of Donguibogam

Cited by 32 publications

References 2 publications

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

A Controlled Fermented Samjunghwan Herbal Formula Ameliorates Non-alcoholic Hepatosteatosis in HepG2 Cells and OLETF Rats

Rapid and Simple Species Identification of Cicada Exuviae Using COI-Based SCAR Assay

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