History of Bioimpedance and Bioelectricity

Grimnes, Sverre; Martinsen, Ørjan Grøttem

doi:10.1016/b978-0-12-374004-5.00010-6

Cited by 333 publications

(547 citation statements)

References 0 publications

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“…Promjene u strukturi i/ili kemijskom sastavu rezultirat će promjenom električne otpornosti tkiva. Na tom principu zasniva se primjena EI-ja u dijagnostičke svrhe u medicini i stomatologiji (1,2). Dijagnostičkim metodama koje se temelje na mjerenju EI-ja koristimo se u različitim područjima medicine.…”

Section: Uvodunclassified

“…Murdoch i suradnici (18) izvijestili su o značajno nižim vrijednostima EI-ja u slučaju oralnih karcinoma i lezija s teškom displazijom, u usporedbi s umjerenom displazijom i zdravom oralnom sluznicom. Zbog neinvazivnosti, metode temeljene na EI-ju imaju određenu prednost nad invazivnim metodama -jednostavnije se obavljaju, ugodnije su pacijentu i manji su problem kad je riječ o dezinfekciji, sterilizaciji i kontroli infekcije (1,16,19). Da bismo se EI-jom mogli koristiti u dijagnostici patoloških promjena oralne sluznice, potrebne su polazišne osnove za komparaciju tj.…”

Section: Richter I Surunclassified

“…Murdoch et al (18) reported significantly lower values of EI in oral cancer and severely dysplastic lesions compared to mild dysplasia and healthy oral mucosa. Being non-invasive, methods based on EI have certain advantages over invasive methods: they are simpler to perform, more comfortable for the patient and pose a lesser problem regarding disinfection, sterilization and infection control (1,16,19). In order to use EI spectroscopy in the diagnostics of oral mucosal lesions, initial values for the comparison are needed i.e.…”

Section: Postupcimentioning

confidence: 99%

“…Structural and/or chemical changes result in changes in the electrical resistance of the tissue. The application of EI in medical and dental diagnostics is based on this principle (1,2). Diagnostic methods based on EI measurement are used in different fields of medicine.…”

Section: Introductionmentioning

confidence: 99%

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Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Richter

Alajbeg

Boras

et al. 2015

Acta Stomatol Croat

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Adresa za dopisivanje izv. prof. dr. sc. Vlaho Brailo Stomatološki fakultet Sveučilišta u Zagrebu Zavod za oralnu medicinu Gundulićeva 5, 10 000 Zagreb brailo@sfzg.hr Sažetak Svrha ispitivanja: Bioimpedancija je otpor prolasku električne struje kroz tkivo i ovisi o njegovoj strukturi i kemijskom sastavu. Svrha istraživanja bila je mapirati bioimpedancijske spektre za svaku regiju usne šupljine. Ispitanici i postupci: U mjerenju bioimpedancije sudjelovalo je tridesetero ispitanika s urednim nalazom oralne sluznice, a obavljalo se na 14 lokalizacija u usnoj šupljini s lijeve i desne strane te je ponovljeno nakon sedam i četrnaest dana. Rezultati: Najniže vrijednosti izmjerene su na dorzumu jezika, a najviše na tvrdom nepcu. Nije ustanovljena statistički značajna razlika između mjerenja na lijevoj i desnoj strani. Statistički značajno više vrijednosti izmjerene su ženama na sluznici gornje usne, dorzumu jezika i na ventralnom dijelu jezika. Utvrđena je statistički značajna razlika između nepušača i pušača na sluznici donje usne i sluznici dna usne šuplji-ne. Vrijednosti bioimpedancije bile su u negativnoj korelaciji s količinom sline na sluznici gornje usne, na tvrdom nepcu, dorzumu jezika i na podjezičnoj sluznici. Mjerenja pri niskim frekvencijama imala su veću varijabilnost. Zaključak: Vrijednosti bioimpedancije najčešće ovise o stupnju keratinizacije sluznice. Na njihove vrijednosti vjerojatno utječu demografski i klinički čimbenici, što je potrebno razjasniti u daljnjim studijama s većim brojem ispitanika. Ključne riječi električna impedancija, oralna sluznicaZavod za oralnu medicinu Stomatološkog fakulteta Sveučilišta

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Section: Uvodunclassified

Section: Richter I Surunclassified

Section: Postupcimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Richter

Alajbeg

Boras

et al. 2015

Acta Stomatol Croat

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“…A body of literature exists that has both measured and modelled the electrical changes in cells and tissue both in vivo and in vitro, as well as provided correlations between electrical properties and cell types; this work has been summarized previously [6][7][8][9][10][11] . From an electrical perspective, a cell can be represented as an ion-rich conductive centre (cytoplasm) embedded in an ion-rich conductive medium (extracellular fluid), separated by a relatively non-conductive barrier (cell membrane).…”

mentioning

confidence: 99%

Impedance sensing device enables early detection of pressure ulcers in vivo

et al. 2015

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When pressure is applied to a localized area of the body for an extended time, the resulting loss of blood flow and subsequent reperfusion to the tissue causes cell death and a pressure ulcer develops. Preventing pressure ulcers is challenging because the combination of pressure and time that results in tissue damage varies widely between patients, and the underlying damage is often severe by the time a surface wound becomes visible. Currently, no method exists to detect early tissue damage and enable intervention. Here we demonstrate a flexible, electronic device that non-invasively maps pressure-induced tissue damage, even when such damage cannot be visually observed. Using impedance spectroscopy across flexible electrode arrays in vivo on a rat model, we find that impedance is robustly correlated with tissue health across multiple animals and wound types. Our results demonstrate the feasibility of an automated, non-invasive 'smart bandage' for early detection of pressure ulcers.

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All Biodisintegratable Hydrogel Biohybrid Neural Interfaces with Synergistic Performances of Microelectrode Array Technologies, Tissue Scaffolding, and Cell Therapy

Lei,

Peng,

Chiu

et al. 2023

Adv Funct Materials

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Biohybrid neural interfaces (BHNIs) are a new class of neuromodulating devices that integrate neural microelectrode arrays (MEAs) and cell transplantation to improve treatment of nerve injuries and disorders. However, current BHNI devices are made from abiotic materials that are usually bio‐passive, non‐biodisintegratable, or rigid, which restricts encapsulated cell activity and host nerve reconstruction and frequently leads to local tissue inflammation. Herein, the first MEA composed of all disintegratable hydrogel tissue scaffold materials with synergistic performances of tissue conformal adhesiveness, MEA technologies, tissue scaffolding and stem cell therapy on a time scale appropriate for nerve tissue repair is proposed. In particular, the MEA conductive tracks are made from extracellular matrix (ECM)‐based double‐cross‐linked dual‐electrically conductive hydrogel (ECH) systems with robust tissue‐mimicking chemical/physical properties, electrical conductivity, and an affinity for neural progenitor stem cells. Meanwhile, the MEA hydrogel substrate prepared from transglutaminase‐incorporated gelatin/silk precursors simultaneously promotes gelation and interfacial adhesion between all MEA stacks, leading to rapid and scalable device integration. When the full hydrogel MEA is subjected to various mechanical stimuli and moisture, it is structurally stable with a low impedance (4 ± 3 kΩ) comparable to a recently reported benchmark. With seamless lamination around peripheral nerve fibers, the device permits successive neural signal monitoring for wound condition evaluation, while demonstrating synergistic effects of spatiotemporally controlled electrical stimulation and cell transplantation to accelerate restoration of motor function. This BHNI is completely degraded by 1 month thus eliminating the need for surgical retrieval to stably remain, interact, and further fuse with host tissues, successfully exhibiting compatible integration of biology and an implanted electrical system.

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History of Bioimpedance and Bioelectricity

Cited by 333 publications

References 0 publications

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Impedance sensing device enables early detection of pressure ulcers in vivo

All Biodisintegratable Hydrogel Biohybrid Neural Interfaces with Synergistic Performances of Microelectrode Array Technologies, Tissue Scaffolding, and Cell Therapy

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