HIV-1 subtypes in Jayapura City, Papua Province Indonesia

Oktavian, Antonius; Kridaningsih, Tri Nury; Wibowo, Holy Arif; Widiyanti, Mirna; Wieke, I.; Fitriana, Eva

doi:10.1016/j.ijid.2012.05.747

Cited by 1 publication

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“…Jenis Subtipe dan karakteristik pasien dapat dilihat pada Tabel 1.PembahasanTabel 1 menunjukkan proporsi CRF01_AE lebih banyak ditemukan pada subyek perempuan, tidak memiliki pekerjaan, status menikah dari suku Papua dan faktor resiko heteroseksual. Pada penelitian ini, CRF01_AE didapatkan lebih banyak dibanding subtipe B. Subtipe ini ditemukan pada penelitian sebelumnya di Kota Jayapura dengan proporsi subtipe B sebesar 66.1% dan CRF01_AE sebesar 33.9%(12). Berbeda dengan hasil yang ditemukan di Kabupaten Jayapura oleh Widiyanti dkk (2013) bahwa subtipe CRF01_AE lebih banyak yaitu 86.1% dibandingkan subtipe B (13.9%)(13).…”

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Heterosexual Transmission as a CRF01_AE HIV-1 Spread Factor in Mimika Papua

Widiyanti

Ubra²,

Iriani

2018

Jour. Health Sci Prev

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The HIV epidemic has particular characteristic on each region. The genetic diversity of HIV-1 would affect variability of HIV virus that could potentially most virulent, pathogenic and high transmission rate. Thus it triggers the disease progresivity more rapidly and caused a new pandemic of HIV infection. The aim of the study is determine the genetic characteristics of HIV-1 on patient with heterosexual transmission based on gene fragment encoding the glycoprotein-41 (gp41) of HIV envelope. Descriptive analytic method and cross sectional design were attended on VCT clinic Mitra Masyarakat Mimika in March-May 2015. Samples of blood plasma from patient with HIV-1 sexual transmission wer amplified using RT-PCR and nested PCR. Genetic characteristics were analyzed with DNA Sequencing using software Bioedit and Mega 5. Identification using sequence analysis showed two subtypes of HIV patient in Mimika, which were CRF01_AE and B subtypes. There were 40 patients (87%) identified as having genetic characteristics CRF01_AE. Subtypes B was also identified in 6 heterosexual patients. This study suggest that CRF01_AE have heterosexual transmission risk higher than subtype B. Predominance of CRF01_AE contribute to the rapid spread of the HIV epidemic in Mimika

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