HIV Infection Deregulates the Balance Between Regulatory T Cells and IL-2–Producing CD4 T Cells by Decreasing the Expression of the IL-2 Receptor in Treg

Méndez-Lagares, Gema; Jaramillo-Ruiz, Didiana; Pion, Marjorie; Leal, Manuel; Muñoz‐Fernández, María Ángeles; Pacheco, Yolanda M.; Correa‐Rocha, Rafael

doi:10.1097/qai.0000000000000092

Cited by 15 publications

(21 citation statements)

References 18 publications

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“…We have previously demonstrated that the depletion of Treg cells seems to be mediated by the direct HIV-1-infection of the Treg cells and the consequent disturbance of their phenotype expression and function [ 9 , 18 ], which has been also confirmed by other authors [ 27 ]. Therefore, new therapeutic approaches directed to impeding the Treg HIV-1 infection and to preserving this population of cells could be of great interest in the HIV-1-infected subjects.…”

Section: Discussionsupporting

confidence: 57%

“…Treg cells were purified by sorter as previously described [ 9 , 10 ]. Then, they were identified as CD4 + CD25 + CD127 low and flow cytometry analysis of isolated Treg cells indicates that >85% were Foxp3+.…”

Section: Methodsmentioning

confidence: 99%

“…The role of Treg cells in HIV-1 infection is critical because of their potential capacity to suppress HIV-1-specific immune responses [ 6 ], but also for their implication preventing hyperactivation of immune system and suppressing chronic inflammation [ 7 , 8 ]. We demonstrated that HIV-1 not only directly infects Treg cells, but also deregulates the function and phenotype that define these cells [ 9 , 10 ]. The loss of Treg suppressive function could be responsible for the hyperactivation of immune system associated to the disease, and could be determinant in the progression of AIDS.…”

Section: Introductionmentioning

confidence: 99%

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Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells

Jaramillo-Ruiz¹,

Mata

Gómez

et al. 2016

PLoS ONE

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BackgroundHIV-1 has proved to infect regulatory T cells (Treg) modifying their phenotype and impairing their suppressive capacity. As Treg cells are a crucial component in the preservation of the immune homeostasis, we researched that the antiviral capacity of carboxilan dendrimers prevents the HIV-1 infection of Treg and their effects. The phenotype and suppressive capacity of Treg treated or non-treated with carbosilane dendrimers were studied by flow cytometry. Treated and non-treated Treg from healthy donors were infected with HIV-1NL4.3. The infection of Treg cells by HIV-1, and protective effect of two dendrimers were determined by measuring antigen p24gag in the supernatant of the culture and intracellular.ResultsThe Treg cells were treated with cationic and anionic carbosilane dendrimers. The results showed that both dendrimers did not modify the phenotype and functionality of Treg cells compared with non- treated Treg cells. Anionic dendrimers showed high biocompatibility with normal activity of the Treg cells and in antiviral assays. These dendrimers were highly active against HIV-1 preventing the infection of Treg, and were able to protect the Treg from the Foxp3 downregulation induced by the HIV-1 infection.ConclusionsThis is the first work showing that the in vitro use of anionic dendrimers prevent the HIV-1 replication and the infection of expanded Treg cells in culture, which raises the possibility to use Treg cells therapeutically in HIV-1-infected subjects.

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Section: Discussionsupporting

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells

Jaramillo-Ruiz¹,

Mata

Gómez

et al. 2016

PLoS ONE

Self Cite

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“…46 Blocking antibodies against IL-2R is in use in organ transplantation follow-up treatment to control the numbers of activated anti-transplant T or B cells.…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Cytokines of the Immune System

Dembić

2015

The Cytokines of the Immune System

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“…Also, reduction in the expression of IL-2R α in Treg cells was observed in HIV-infected subjects with high viral load. This alteration could result in reduced Treg cells capacity function in these individuals, considering that the homeostatic role of this cells depends on IL-2 and the expression of IL-2R α at the cell surface [ 37 ].…”

Section: The Role Of Treg Cells On Hiv Infectionmentioning

confidence: 99%

New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression

Valverde-Villegas

Matte

Medeiros

et al. 2015

Journal of Immunology Research

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Treg and Th17 cell subsets are characterized by the expression of specific transcriptional factors and chemokine receptor as well as by secretion of specific cytokine and chemokines. These subsets are important to the differentiation, expansion, homing capacity, and recruitment of several different immune cell populations to the site of infection. Whereas Treg cells maintain self-tolerance and control the activation and expansion of autoreactive CD4+ T effector cells through an anti-inflammatory response, Th17 cells, in an exacerbated unregulated proinflammatory response, can promote autoimmunity. Despite such apparently opposite functions, Th17 and Treg cells share common characteristics, and their differentiation pathways are interconnected. Recent studies have revealed quite intricate relations between Treg and Th17 cells in HIV infection and progression to AIDS. Considering Treg cells, different subsets were already investigated in the context of HIV infection, indicating a fluctuation in the total number and frequency throughout the disease course. This review focuses on the recent findings regarding the role of regulatory T and Th17 cells in the context of HIV infection, highlighting the importance of the balance between these two subsets on disease progression.

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HIV Infection Deregulates the Balance Between Regulatory T Cells and IL-2–Producing CD4 T Cells by Decreasing the Expression of the IL-2 Receptor in Treg

Cited by 15 publications

References 18 publications

Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells

Nanotechnology as a New Therapeutic Approach to Prevent the HIV-Infection of Treg Cells

Cytokines of the Immune System

New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression

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