HL-A antigens in patients with guttate psoriasis

Williams, Robert C.; McKenzie, A L; Roger, James; Joysey, V.

doi:10.1111/j.1365-2133.1976.tb00820.x

Cited by 41 publications

(30 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another disease manifestation is guttate psoriasis that presents itself as sudden dissemination of small, red, and scaly papules. Guttate psoriasis is frequently identified as the first manifestation of the disease in younger individuals and is reported to develop into chronic plaque psoriasis in a large proportion of patients (Williams et al, 1976). Flares of guttate psoriasis can also occur in individuals with chronic plaque psoriasis.…”

mentioning

confidence: 99%

Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis

Carlén

Sánchez

Bergman

et al. 2005

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Psoriasis is a disease with considerable heterogeneity in clinical presentation. This is the first study using two-dimensional gel electrophoresis to compare global protein expression patterns in lesional and non-lesional skin from subjects with acute guttate psoriasis associated with streptococcal throat infection and chronic plaque psoriasis. Samples from experimentally induced contact eczema and normal skin from healthy controls were also included. Proteins with statistically significant differences in expression were used in hierarchical cluster analyses resulting in separation of the different samples into groups. Chronic plaque and guttate psoriasis samples were distinctly separated, indicating that they represent discrete phenotypes at the protein expression level. Interestingly, there was a trend in which guttate psoriasis lesions clustered closer to eczema than to chronic plaque psoriasis lesions, indicating that the duration of the inflammatory reaction may affect clustering. Several of the differentially expressed proteins were identified by mass spectrometry.

show abstract

mentioning

confidence: 99%

Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis

Carlén

Sánchez

Bergman

et al. 2005

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…The predominant phenotype, however, may change into other types in the course of disease. For example, chronic plaque psoriasis may transform into inflamed guttate lesions; conversely, guttate psoriasis develops into plaque psoriasis in approximately 70% of patients8. The mechanism underlying this change in psoriatic phenotype is not clearly understood, but it may be related to a hyperactive immune pathology associated with intercurrent infections, differences in susceptibility or disease-modifying genes5.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients

et al. 2017

View full text Add to dashboard Cite

BackgroundAlthough phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines.ObjectiveTo investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy controls, and 2) between patients with different psoriasis phenotypes.MethodsTwenty-five patients with psoriasis (10 with guttate psoriasis and 15 with plaque psoriasis) and 5 healthy volunteers were enrolled in this study. The mRNA levels of circulating cytokines (interleukin [IL]-2, IL-12p40, interferon-γ, IL-17A, IL-22, and IL-23R) were measured by real-time reverse transcription polymerase chain reaction.ResultsThe comparison between psoriatic and healthy control samples revealed that IL-12p40, IL-17A, and IL-22 mRNA levels were significantly higher (approximately 4∼6 folds) in the patients with psoriasis. The mRNA levels of these six cytokines in the blood did not differ between the guttate and plaque psoriasis groups.ConclusionWe found that the mRNA levels of blood inflammatory cytokines (IL-12p40, IL-17A, and IL-22) were significantly elevated in patients with psoriasis compared to the levels in healthy controls, but they did not significantly differ between patients with guttate and plaque type psoriasis.

show abstract

“…Associations between HLA anti gens and infection-related exacerbation [Karvonen, 1975], streptococci-related guttate psoriasis [Schoejim'M.vetal., 1974;Williams et al, 1976] and the humoral immune response to streptococcal antigens [Bertrams et al, 1974] have also been reported in psoriasis.…”

Section: Introductionmentioning

confidence: 99%

HLA-Related Lymphocyte Responsiveness in Psoriasis

Gross¹,

Vorwerk²,

Westphal³

et al. 1983

Int Arch Allergy Immunol

View full text Add to dashboard Cite

In order to find associations among the genetic, immunological and environmental factors that might be important in the pathogenesis of psoriasis, the relationship between streptococcal antigen- or mitogen-induced lymphocyte responses in vitro and HLA phenotypes was studied in 23 patients with psoriasis. Patients showed an elevated lymphocyte response to somatic A-streptococcal antigens when compared with healthy controls. In contrast, the response to mitogens (PHA, Con A, PWM) was impaired in patients with psoriasis. The impaired mitogen-induced lymphocyte transformation was found mostly in psoriatics with HLA-B13/B17. The elevated cellular immune response to somatic A-streptococcal antigens, on the other hand, was observed mainly in psoriatics without HLA-B13/B17. The results indicate that gene products of the HLA region known to be associated with psoriasis are involved in the cellular immune response, as expected from clinical trials. These findings also provide further evidence of at least two different subtypes of psoriasis, characterized by genetically and immunologically defined markers.

show abstract

HL-A antigens in patients with guttate psoriasis

Cited by 41 publications

References 15 publications

Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis

Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis

Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients

HLA-Related Lymphocyte Responsiveness in Psoriasis

Contact Info

Product

Resources

About