HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

Arnaiz‐Villena, Antonio; Karin, Meina; Bendikuze, N.; Gómez-Casado, Eduardo; Moscoso, Juan; Silvera, Carlos; Oğuz, Fatma; Diler, A. Sarper; Pacho, A.; Allende, Luis M.; Guillén, J.; Laso, J. Martínez

doi:10.1034/j.1399-0039.2001.057004308.x

Cited by 94 publications

(104 citation statements)

References 23 publications

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“…Thus, the genetic data support the hypothesis that present day Iranian main genetic stock comes from the ancient autochthonous people and a genetic input from eastern people would be a minor one (Arnaiz-Villena et al 2001c;Arnaiz-Villena et al 2002). …”

Section: Discussionsupporting

confidence: 63%

“…Genetic substratum of Anatolian people (Turkish) has been defined as Mediterranean with a little genetic but a high cultural influence of Oghuz Turks (Arnaiz-Villena et al 2001c;Arnaiz-Villena et al 2002). Despite several Anatolian invasions (Sellier and Sellier, 1993), the present day Turkish HLA profile reflects an older Mediterranean substratum not far from Cretans, Sardinians, Macedonians and Croatians (Fig 2 and Fig 3).…”

Section: Azeris and Anatolian And Caucasus Populationsmentioning

confidence: 99%

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Origin of Azeris (Iran) according to HLA genes

Arnaiz‐Villena¹,

Palacio-Grüber²,

Muñiz³

et al. 2017

Int.J.Mod.Anthrop

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Section: Discussionsupporting

confidence: 63%

Section: Azeris and Anatolian And Caucasus Populationsmentioning

confidence: 99%

Origin of Azeris (Iran) according to HLA genes

Arnaiz‐Villena¹,

Palacio-Grüber²,

Muñiz³

et al. 2017

Int.J.Mod.Anthrop

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“…The similarity of the Lebanese alleles to those of the above-mentioned eastern Mediterranean countries as well as other countries, including Algeria (13) and Hungary (29), may be explained by the admixture brought about by the migration of Phoenicians (ancestors of present-day Lebanese) to North Africa and southern Europe. Analysis of the Bahraini HLA class II alleles and haplotypes revealed some relatedness to their Lebanese counterparts and also to those of neighboring and distant ethnic groups, as exemplified by DRB1*1101 and DRB1*16011 (6,27), which suggests the influence of these populations on this distinct Arab population. The strongest similarity that the Bahrainis had was with their related Arabian Gulf neighbors, as exemplified with DRB1*030101, which is also highly frequent among healthy Saudi (2) and Kuwaiti (3,15) Arabs.…”

Section: Discussionmentioning

confidence: 99%

“…This has significant implications for analyzing human migration trends throughout history (14). Studies of the HLA origin of Arabs are scanty, but studies of related eastern and western Mediterranean groups including Turks, Iranians, Jews, Lebanese, and others suggest a common ancestry (6,8,24). Variation in HLA class II distribution among these populations can be explained by the admixture of the ancient population with invading and migratory societies, which may have given rise to present-day racial and ethnic groups (8).…”

mentioning

confidence: 99%

HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs

Almawi

Busson

Tamim

et al. 2004

Clin Vaccine Immunol

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The gene frequencies of HLA class II alleles were studied in 95 healthy Lebanese Arab and 72 healthy Bahraini Arab subjects. Our aim was to establish the genetic relationship between Bahraini and Lebanese Arabs in terms of HLA class II gene and haplotype frequencies and to compare these results with frequencies for other countries with populations of Caucasian and non-Caucasian descent. Subjects were unrelated and of both sexes, and HLA-DRB1 and -DQB1 genotyping was done by the PCR sequence-specific primer technique. Comparative analysis of the HLA-DR and -DQ alleles revealed differences in the allelic distribution among Bahraini and Lebanese subjects. Analysis of the 25 HLA-DRB1 alleles that have been investigated showed that the DRB1*040101 and DRB1*110101 alleles were more frequent among Lebanese, whereas DRB1*030101 and DRB1*160101 alleles were more frequent among Bahrainis. Similarly, of the seven HLA-DQB1 alleles analyzed, the presence of DQB1*0201 was more frequent among Bahrainis, whereas DQB1*030101 was more frequent among Lebanese. The DRB1*160101-DQB1*050101 (0.1318 versus 0.0379%) and DRB1*030101-DQB1*0201 (0.1202 versus 0.0321%) haplotypes were more frequent among Bahrainis, while the DRB1*110101-DQB1*030101 (0.3142 versus 0.1198%) and DRB1*040101-DQB1*0302 (0.1416 versus 0.0278%) haplotypes were more frequent in Lebanese subjects. Furthermore, a high prevalence of the DRB1*040101-DRB1*110101-DQB1*0302-DQB1*030101 (12.63 versus 1.35%, P ‫؍‬ 0.015) and the homozygous DRB1*110101-DRB1*110101-DQB1*030101-DQB1*030101 (7.37 versus 0.00%, P ‫؍‬ 0.046) genotypes was seen among Lebanese, and DRB1*070101-DRB1*160101-DQB1*0201-DQB1*050101 (6.76 versus 0.00%, P ‫؍‬ 0.034) was seen more frequently among Bahraini subjects. Our results underline significant differences between these two populations in HLA class II distribution, provide basic information for further studies of major histocompatibility complex heterogeneity among Arabic-speaking countries, and serve as a reference for further anthropological studies.

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“…[3][4][5][6][7] Limited data are available on the frequencies of HLA class I and class II antigens and haplotype profiles in small populations within Turkey. [8][9][10][11][12][13] Our aim was to assess the frequency of HLA-matched family donors in the Turkish population and to identify the HLA antigens and haplotypes that are most frequent in Turkey.…”

Section: Introductionmentioning

confidence: 99%

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Kaya

Gönen²,

Çalışkan³

et al. 2019

Exp Clin Transplant

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Objectives: Allogeneic hematopoietic stem cell transplant is a life-saving treatment, but donor numbers in Turkey do not meet the increasing demand for this procedure. Here, our objectives were (1) to assess the frequency of HLA-matched related donors in the Turkish population and (2) to identify the HLA antigens and haplotypes that are most frequent in Turkey. Materials and Methods: The HLA genotypes of 841 consecutive recipients and 3071 family members were retrospectively reviewed. Results: Matched related donors were identified for 368/841 recipients (44%). Extended family donor searches were performed for 111/181 pediatric recipients (61%), with nonsibling matched related donors found for 23 patients (21%). Matched related donors were found for a significantly higher proportion of pediatric patients (52%) than adult patients (41%) (odds ratio of 2.5; 95% confidence interval, 1.9-4.1; P = .02). The percentage of pediatric versus adult patients with 3 or more siblings was 13% versus 46% (odds ratio of 5.6; 95% confidence interval, 3.6-8.5; P = .001). The most frequent HLA class I antigens at each locus were HLA-A*02 (20.2%), HLA-B*35 (19.5%), and HLA-C*07 (19.8%). The most frequent HLA class II antigens at each locus were HLA-DRB1*11 (21.6%) and HLA-DQB1*03 (40.2%). The most common 3-locus haplotypes were HLA-A*24 B*35 DRB1*11 (F:0.020) and HLA-A*01 B*08 DRB1*03 (F:0.015). When adult and pediatric groups were combined, the most common locus haplotypes were found in 43/345 sibling donors (12%) and in 7/23 nonsibling pediatric donors (30%) (odds ratio of 2.7; 95% confidence interval, 1.2-6.4; P = .02). Conclusions:The results indicate that, in Turkey, it can be beneficial to revise donor search algorithms to include an extended family donor search before an unrelated donor search. This type of search can be effective because of the HLA haplotype diversity in Turkey, the frequency of consanguinity, and the country's limited donor pool.

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HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

Cited by 94 publications

References 23 publications

Origin of Azeris (Iran) according to HLA genes

Origin of Azeris (Iran) according to HLA genes

HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

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