HLA and Cancer in South African Negroes

Hammond, M. G.; Appadoo, B.; Brain, Peter

doi:10.1111/j.1399-0039.1977.tb01072.x

Cited by 21 publications

(5 citation statements)

References 3 publications

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“…A survey of cancer in the Negro and Indian populations of Durban (Schonland & Bradshaw 1968) showed that the overall cancer incidence in females of both races and in Negro males is as high as in most Western countries, but Indian males have a low overall cancer incidence which is not readily explained. We have previously reported our findings with regard to HLA and cancer in South African Negroes (Hammond et al 1977a). The Indian population can be divided into four major ethnic groups and we have shown that there are differences in the frequencies of the HLA antigens in these groups.…”

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confidence: 53%

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HLA and Cancer in South African Indians

Hammond¹,

Appadoo²,

Brain³

1979

Tissue Antigens

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Two‐hundred‐and‐forty‐nine Indian cancer patients were tested for 39 HLA antigens and the antigen frequencies were compared with those of 603 control subjects. Comparisons were also made between cancer patients and controls for each ethnic group and for each site of cancer. There was an increase in the frequency of the HLA antigens A11 and Bw52 in patients with malignancies. Heterozygosity at the B locus was significantly increased in patients with cancer of the breast. The Aw24, B17 haplotype was also associated with breast cancer.

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confidence: 53%

“…Their specificity was confirmed during the Sixth and Seventh Histocompatibility Workshops. The subdivision of Bw40 in Indians into Bw40.1, Bw40.2, and of B5 into four components was reported a t the Seventh Workshop (Hammond et al 1975(Hammond et al , 1977b. In this report, B5 cells that were not Bw51 or Bw52 were classed as Bw5 IND.…”

Section: Methodsmentioning

confidence: 77%

HLA and Cancer in South African Indians

Hammond¹,

Appadoo²,

Brain³

1979

Tissue Antigens

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“…The phenotypic combination Aw30, B7-Bw42 was also reduced in the patients (RR 0.22). Aw30 and Bw42, but not Aw30 and B7, are in positive linkage disequilibrium (Hammond et al 1977). When the combinations Aw30, B7 and Aw30, Bw42 were analysed separately, both were found to be reduced in frequency as compared to controls but not notably so, possibly bccause of the small number5 of subjects (Aw30, H7: 0% and 5.5%: Aw30, Bw42: 3.6% and 8.7% in patient and control groups respectively).…”

Section: Discussionmentioning

confidence: 86%

HLA antigens and Graves' disease in Black South Africans

et al. 1983

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This study concerns the frequencies with which 36 HLA‐A, ‐B and ‐C antigens occurred in 84 Black Africans with Graves' disease and in 311 Black controls. In the hyperthyroid patients significant reductions were found in the frequencies of HLA‐B7 (P<0.001, relative risk (RR) 0.33), HLA‐Bw42 (P <0.001, RR 0.32) and the HLA‐B7‐Bw42 crossreactive group (CREG) (P <0.0001, RR 0.27), and in the frequencies of the phenotypic combinations HLA‐A1, B7 (P <0.001) and Aw30, B7‐Bw42 (P <0.001). HLA‐B8 was increased in frequency (P <0.01, RR 2.84). In patients without circulating antithyroglobulin or antimitichondrial antibodies the frequencies of HLA‐A2 and B17 were increased when compared to those with antibodies or to the controls. In patients with and without clinically evident infiltrative ophthalmopathy the frequencies of HLA antigens were similar. In 62 Caucasian patients with Graves' disease, no antigens or phenotypic combinations occurred with increased or decreased frequency when compared to 278 controls. Analysis of the frequencies of 9 HLA antigens and phenotypic combinations common in Caucasians but rare in Blacks revealed that only two antigens (A2 and B8) occurred with increased frequency in Black patients, suggesting that a contribution of Caucasian genes to the Black thyrotoxic subjects was unlikely. Similarly, only one common Black antigen (A28) of 8 common antigens and phenotypic combinations, occurred in Caucasian patients with a frequency similar to that of Black controls. Thus it is unlikely that Black genes contributed to the lack of a significant increase of HLA antigens in the Caucasian thyrotoxic patients. The possession of HLA‐B7‐Bw42 CREG or related genes may be a protection against Graves' disease in Black Africans.

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“…The IDDM patients were characterized by onset under 35 years and a dependence on insulin for control of symptoms and for the prevention of basal ketosis (West 1978). The antigen frequencies were compared with those found in a healthy control population, many of whom were typed for Inter-national Workshops (Hammond et al 1975(Hammond et al , 1977.…”

Section: Methodsmentioning

confidence: 99%