HLA‐B*4703: sequence confirmation, serology and distribution

Darke, C.; Guttridge, M. G.; Street, J.; Thompson, John; Thomas, Mélanie

doi:10.1034/j.1399-0039.1999.530611.x

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…These findings strengthen our view that, even in the era of DNA‐based typing, the careful evaluation of serological reaction patterns can be fruitful in the identification of new and rare alleles ( 19–21). They also suggest that the HLA‐A2403 specificity should now be appended to other HLA‐A*24 alleles.…”

Section: Detection Of the A * 2403/10/18/22/23/33 Allele Group And Itsupporting

confidence: 71%

Observations on the HLA‐A2403 specificity

et al. 2003

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We found HLA-A*2423 in a subject possessing the HLA-A2403 specificity. Consequently we delineated the A*24 alleles of 41 subjects previously assigned as 'A2403' by serology and/or 'low-resolution' PCR-SSP (allele group: A*2403/10/18/22/23/33) and found that 36 were A*2403, 3 were A*2410 and 2 were A*2433. The A*2410 and A*2433 subjects also typed as A2403. Several likely A*2410/23/33-bearing haplotypes were identified and the frequency of the A*2403/10/18/22/23/33 alleles was determined in 26,826 Welsh blood donors. We suggest that HLA-A9/A24 antibodies against epitope(s) involving 166D and 167G will fail to react with all A*2403/10/18/22/23/33 products. As it is this 'short' A9/A24 serological reactivity that defines HLA-A2403 all these products will be serologically designated as HLA-A2403.

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Section: Detection Of the A * 2403/10/18/22/23/33 Allele Group And Itsupporting

confidence: 71%

Observations on the HLA‐A2403 specificity

et al. 2003

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“…Nucleotide sequencing of B*4408 was performed using PCR‐generated templates from allele‐specific primer mixtures for exon 2 [containing primers 5Bin1‐TA and R219 (5′‐CCAGGTATCTGCGGAGCG‐3′)] and exon 3 [containing primers L243 (5′‐CGCGAGTCCGAGGATGGC‐3′) and 3Bin3‐37 (Cereb & Yang, 1997)] as previously described (Darke et al ., 1999; Guttridge et al ., 1999).…”

Section: Methodsmentioning

confidence: 99%

Immunogenetics of the rare HLA‐B allele B*4408^†

Street¹,

Downing²,

Darke³

2003

European Journal of Immunogenetics

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The nucleotide sequence of exons 2 and 3 of B*4408 has been confirmed. This allele has now been found in five, apparently unrelated, north-western European Caucasoid subjects, residing in Wales, on HLA haplotypes bearing: A*0201, Cw*0501 with DRB1*0401, DQA1*03, DQB1*0301 in four instances and DRB1*0701, DQA1*0201, DQB1*0202 in one instance. The unique serological reactivity of 'HLA-B44BO' was established using up to nine B*4408 subjects and was easily identified using a variety of B44 and B62 antisera. The phenotype and gene frequencies of B*4408, in a sample of 40 473 subjects residing in Wales, were 0.01235% and 0.00006, respectively.

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“…During routine ‘low resolution’ (minimum of ‘2‐digit” allele level) five‐locus HLA typing of patients, and blood donors enrolling on the Welsh Bone Marrow Donor Registry (WBMDR) (4) we identified two subjects who gave unexpected amplification patterns by polymerase chain reaction using sequence specific primers (PCR‐SSP). Nucleotide sequencing of exons 2 and 3 (5, 6) of the aberrant HLA‐A and B alleles identified two new class I alleles – A*0108 and B*0431 1 .…”

Section: Identification Of Hla‐a*0108 By Pcr‐sspamentioning

confidence: 99%

Immunogenetics of two new HLA alleles: A0108 and B4031

et al. 2003

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Two new alleles, HLA-A*0108 and B*4031, were identified in north-western European Caucasoid subjects. A*0108 differed from A*010101 by a single substitution (C to T) at position 216 in exon 3, resulting in an amino acid difference of Arg to Trp at position 163. It was present on a haplotype with B*1501/60/70/71; Cw*0303; DRB1*1301; DRB3*0202; DQA1*0103; DQB1*0603 and its product reacted as a normal HLA-A1 specificity. B*4031 differed from B*4001 by two nucleotides in exon 3 (positions 20 (G to C) and 69 (A to G)) resulting in two amino acid differences (Arg to Ser at position 97 and Asn to Asp at position 114). It was found on a haplotype with HLA-A*03; Cw*0304; DRB1*0404/32; DRB4*0101/3/5; DQA1*03; DQB1*0302 and has the HLA-B60 specificity. Both alleles have frequencies of < 0.0002 in the largely north-western European Caucasoid blood donor population resident in Wales.

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HLA‐B*4703: sequence confirmation, serology and distribution

Cited by 14 publications

References 20 publications

Observations on the HLA‐A2403 specificity

Observations on the HLA‐A2403 specificity

Immunogenetics of the rare HLA‐B allele B*4408^†

Immunogenetics of two new HLA alleles: A0108 and B4031

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HLA‐B*4703: sequence confirmation, serology and distribution

Cited by 14 publications

References 20 publications

Observations on the HLA‐A2403 specificity

Observations on the HLA‐A2403 specificity

Immunogenetics of the rare HLA‐B allele B*4408†

Immunogenetics of two new HLA alleles: A*0108 and B*4031

Contact Info

Product

Resources

About

Immunogenetics of the rare HLA‐B allele B*4408^†

Immunogenetics of two new HLA alleles: A0108 and B4031