HLA-B27 and Ankylosing Spondylitis

Tsai, Wen-Chan

doi:10.5772/30113

Cited by 2 publications

(2 citation statements)

References 71 publications

(56 reference statements)

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“…The prevalence of males over women for this condition (ranges from 2.6:1 to 5:1) is higher in the second or third decade, and the immediate relations of affected individuals have a 12% prevalence of SpA. 5,6 The most prevalent subgroup of SpA is ankylosing spondylitis, and it has a high relationship with HLA-B27, which has been noted in various research for more than 30 years. Several investigations have also demonstrated the infective significance of the gene B27 from the onset of AS.…”

Section: Introductionmentioning

confidence: 99%

“…Several investigations have also demonstrated the infective significance of the gene B27 from the onset of AS. 6,7 Identification of HLA-B27 has been considered a genetic marker that significantly aids in detecting illness. [8][9][10] The correlation between ankylosing spondylitis and HLA B27 was initially noted in 1973 11 and subsequently proven to be connected to different forms of spondyloarthritis by many researchers.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Thulukanam¹,

Leela²,

Venkatesan³

et al. 2023

J. Pure Appl. Microbiol.

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Human leukocyte antigens (HLA) are genetically derived proteins in the major histocompatibility complex. They help distinguish “self” and “non-self” antigens and are essential in interacting with the immune cells inside the body. The present research work examines the prevalence of HLA-B27 among patients suspected of Spondyloarthritis (SpA), which has also been correlated with Interleukin-17/23 Inflammatory Markers and other clinical manifestations and was carried out between August 2017 to January 2021. The patient’s blood samples were collected and tested for HLA-B27 and Interleukin-17/23 inflammatory markers. Among 289 SpA patients, 60% (172) were males, and 40% (117) were females, with a ratio of 1.5:1. Ankylosing Spondylitis (65.1%) was found to be the most prevalent subgroup of SpA among the patients, closely followed by reactive arthritis (21%), psoriatic arthritis (10.7%), undifferentiated spondyloarthritis (2.1%), and inflammatory bowel disease with associated arthritis (1%). HLA-B27 was found to be positive in 54% (156) out of 289 patients. Normal IL-17 ranges were seen in 42% of HLA-B27- positive patients, while increased IL-17 was seen in 58% of the population with positive HLA-B27 cases. IL-23 was found within normal ranges in 40% of positive HLA-B27 cases, while it was found to be increased in 60% of the positive HLA-B27 positive subjects. We concluded that HLA-B27 was found to be positive among more than half of the patient population with SpA. The early detection of HLA-B27 may aid in changing lifestyle to prevent Spondyloarthritides.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Thulukanam¹,

Leela²,

Venkatesan³

et al. 2023

J. Pure Appl. Microbiol.

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A case of ankylosing spondylitis from the excavations at Kılıçlı Necropolis (Sinope, Northern Turkey) and its implications on the antiquity of the disease in Anatolia

Duyar

2019

Intl J of Osteoarchaeology

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Ankylosing spondylitis (AS) is a chronic, inflammatory, and progressive rheumatic disease that is a member of a family of disease referred to as spondyloarthritis. Although the prevalence estimates of AS vary from 0.25% up to 4.5% in living human populations, the frequency of the disease in the past has not yet been determined. Some suspected AS cases have been reported only based on the vertebral ankyloses or fusions of sacroiliac joints dating from the Neolithic period to the Middle Ages among ancient Anatolian populations, but the AS diagnosis has not been definitively revealed in these cases. In this study, we aimed to identify an AS case that has AS‐originated pathological changes on a relatively well‐preserved middle‐aged male skeleton, recovered from the archaeological excavation of Kılıçlı Church, Sinope, Northern Turkey and dated to the 18–9th centuries. In addition, we made a differential diagnosis with other pathologies such as diffuse idiopathic skeletal hyperostosis, reactive arthritis, and psoriatic arthritis. In the specimen, there are four macroscopic features that are diagnostic of AS: (a) both sacroiliac joints were symmetrically obliterated, (b) spinal fusion was observed without skipping any vertebrae, (c) the spine has “bamboo spine” appearance, and (d) the vertebral syndesmophytes caused squaring of the vertebral bodies. We conclude that the Kılıçlı skeleton, one of the few archaeological specimens showing all symptoms of AS disease, is the first convincing case in Anatolia.

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HLA-B27 and Ankylosing Spondylitis

Cited by 2 publications

References 71 publications

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

A case of ankylosing spondylitis from the excavations at Kılıçlı Necropolis (Sinope, Northern Turkey) and its implications on the antiquity of the disease in Anatolia

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