HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: evidence from a family‐based and case‐control study

Howell, W. M.; Turner, Stephen J.; Hourihane, Jonathan; Dean, Tara; Warner, J. O.

doi:10.1046/j.1365-2222.1998.00224.x

Cited by 103 publications

(72 citation statements)

References 34 publications

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“…[5][6][7] An association has been previously demonstrated between DQB1 allele and PA by Howell et al 7 The present results do not replicate the increase of the DQB1*04 allele in PA cases as previously published; 7 however, we showed an increase of the DQB1*06:03P allele and a decrease of the DQB1*02, DQB1*03:02P, DQB1*05 and DQB1*05:01P alleles in PA subjects compared with controls. The association of the DQB1*06:03P and DQB1*02 alleles with PA remained significant after adjusting for asthma status and sex.…”

Section: Discussioncontrasting

confidence: 51%

“…3 Genes of the HLA family, which are part of the major histocompatibility complex (MHC) locus, are involved in antigen presentation to T cells. As asthma and food allergy are known to be clinically correlated, 4 a few studies have examined MHC class II genes (HLA-DR, -DQ and -DP families) in the context of PA [5][6][7] but only one study has shown a link between these genes and hypersensitivity to peanut. 7 To better understand the genetic component of PA, we compared the HLA-DQB1 allele and genotype frequencies in children with PA and children without PA and demonstrated an association between the HLA-DQB1 gene and this disease.…”

Section: Introductionmentioning

confidence: 99%

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HLA-DQB102 and DQB106:03P are associated with peanut allergy

et al. 2013

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Peanut allergy (PA) is a common and serious food allergy and its prevalence has increased in the past decade. Although there is strong evidence of inheritance, the genetic causes of this disease are not well understood. Previously, a large-scale genomewide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls. Firth's logistic regression analyses showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P ¼ 1.1 Â 10 À8 , odds ratio (OR) ¼ 0.09 (CI ¼ 0.03-0.23)) and DQB1*06:03P alleles (P ¼ 2.1 Â 10 À2 , OR ¼ 2.82 (CI ¼ 1. 48-5.45)). This study of HLA in PA demonstrates specific association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and DQB1*06:03P) and PA, highlighting its possible role in the development of this disease.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

HLA-DQB102 and DQB106:03P are associated with peanut allergy

et al. 2013

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“…6,23 Previous studies have provided evidence for association between susceptibility to allergy (with or without asthma-related symptoms), and HLA-DR4 and/or the DR7 allele. 24 Howell et al 25 have also demonstrated significant increase in HLA-DRB1*08, and the DQB1*04 allele in peanut allergy patients.…”

Section: Discussionmentioning

confidence: 93%

Polymorphism in the STAT6 gene encodes risk for nut allergy

et al. 2002

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“…Regarding a food allergy diagnosis, although children were not food challenged, the definition of food allergy for this study was more stringent than most published large-scale epidemiologic studies of food allergy. [23][24][25][26][27] A unique strength of this study was that families of children with food allergy were enrolled along with their siblings, who may or may not had allergic diagnoses. The subjects and controls were of similar genetic makeup and were raised similarly.…”

Section: Discussionmentioning

confidence: 99%