HLA-DQA1 and -DQB1 allele typing in southern Taiwanese women with breast cancer

Chen, Po-Chih; Tsai, Eing‐Mei; Er, Tze‐Kiong; Chang, Su-Jen; Chen, Bai-Hsiun

doi:10.1515/cclm.2007.132

Cited by 9 publications

(15 citation statements)

References 22 publications

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“…Despite a 4-fold increase in breast cancer incidence from 1979 to 2003 in Taiwan, 48.2% of female breast cancer cases diagnosed in 2005 remained under the age of 50 years, indicating that the preponderance of breast cancer in young females has not changed as lifestyle changes. To explain this early age of tumor onset, genetic polymorphisms (23,(33)(34)(35)(36) and the association between lipid profiles and breast cancer (37) have been rigorously studied; however, the etiologic factors remain obscure. Exploring the pathogenesis of second primary cancers might provide some insight into breast cancer etiologies in this region.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Lee

Chen

Chan

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Studies conducted in Western countries have reported excess risks for second primary malignancies after breast cancer. However, there is little documentation of ethnic differences in these excess risks. Asian women are characterized by younger age at diagnosis of breast cancer, but very few reports are available on the incidences and risks for second primary cancers in this region. Using population-based data from the Taiwan National Cancer Registry (TNCR) for the period 1979 to 2003, we quantified standardized incidence ratios and cumulative incidence of second cancers among 53,783 women with initial diagnoses of breast cancer. Age-specific incidences showed peaks among women in their 40s, and 1,085 cases (2.02%) developed nonbreast second primary cancers. The risk for second cancers differs significantly according to age at diagnosis of breast cancer. In comparison with women diagnosed when z50 years (standardized incidence ratio, 0.96; 95% confidence interval; 0.89-1.04), there were significantly greater risks for bone, corpus uterine, ovarian, thyroid, esophageal, kidney and lung cancers, nonmelanoma skin cancer, and leukemia or lymphoma in women diagnosed when <50 years (standardized incidence ratio, 1.43; 95% confidence interval, 1.29-1.58). The survival probabilities differed between breast cancer patients with and without second cancers (P < 0.001). After diagnosis of the second cancer, the median survival time was only 2.87 years. In conclusion, we confirmed that young age at diagnosis of breast cancer predicted a subsequently increased risk for second malignancies, and the second cancers indeed worsen survivorship in patients who survived breast cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2647 -55)

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Section: Discussionmentioning

confidence: 99%

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Lee

Chen

Chan

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In contrast to other studies carried out among Taiwan (Chen et al, 2007) and Chinese (Yang et al, 2011). Chen et al (2007) used PCR-SSP typing for HLA-DQB1 locus in order to compare the allele frequencies between breast cancer patients and healthy controls in southern Taiwan.…”

Section: Hla-dqb1 and Hla-drb1 Mhc Class-ii Alleles And Breast Cancermentioning

confidence: 57%

“…Chen et al (2007) used PCR-SSP typing for HLA-DQB1 locus in order to compare the allele frequencies between breast cancer patients and healthy controls in southern Taiwan. They showed that HLA-DQB1*05 had higher frequencies but not statistically significant among control compared to the patient.…”

Section: Hla-dqb1 and Hla-drb1 Mhc Class-ii Alleles And Breast Cancermentioning

confidence: 99%

“…HLA class II alleles play an important role in immunity (Chen et al, 2007) and tumor surveillance since the function of the products of the highly polymorphic MHC loci is to present peptide fragments including tumor antigens to the cells of immune system. MHC class II regulate the immune response against tumors (Redondo et al, 2003), by guiding the activation of CD4+ T helper lymphocytes (Alfonso et al, 2000;Scanlan et al, 2001;Goa et al, 2003;Horton et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Negative Association of the HLA-DQB1^*02 Allele with Breast Cancer Development among Jordanians

Atoum

Tanashat²,

Mahmoud³

2013

Asian Pacific Journal of Cancer Prevention

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“…Each individual inherits specific combinations of HLA alleles known as haplotypes [8]. The correlation of certain HLA‐class I and HLA class‐II haplotypes with tumorigenesis has been documented in a variety of tumors [6,9–12]. Kubler et al.…”

Section: Introductionmentioning

confidence: 99%

Association between HLA‐DQA1, HLA‐DQB1 and oral cancer

Tsai

Sheen

Chen

2011

The Kaohsiung J of Med Scie

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Cancer is one of the most common causes of morbidity and mortality. Genes whose products play a critical role in regulation of the immune response include the HLA antigen and cytokine families of genes. Oral cancer is common in men in developing countries, and its frequency is increased by using betel-quid, tobacco, and alcohol. The association between certain HLA Class I and Class II haplotypes and cancer has been documented in a variety of tumors. There was no previous data concerning the association of specific HLA Class II DQA1, DQB1 alleles, or haplotypes with oral cancer patients. In this study, we enrolled 134 Taiwanese patients with histologically confirmed oral cancer and 268 age- and gender-matched healthy Taiwanese adults as control group to investigate the association between HLA-DQA1, HLA-DQB1 allele frequencies and oral cancer patients by using polymerase chain reaction with sequence-specific primers. We found that both HLA-DQA1* and HLA-DQB1* allele frequencies in oral cancer patients revealed no significant difference from those of control groups. Haplotype frequencies of HLA*DQA1-0103-DQB1*0601 in oral cancer patients were significantly lower than those of the control group (odds ratio: 0.18, 95% confidence interval: 0.054-0.583, p(c)=0.02). Our data suggest that HLA DQA1*0103-DQB1*0601 haplotype may be protective with regard to the development of oral cancer.

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HLA-DQA1 and -DQB1 allele typing in southern Taiwanese women with breast cancer

Abstract: We have established a significant lack of HLA-DQA1 and -DQB1 association with breast cancer in southern Taiwanese women. The results of this study may provide information for further clarification of the etiology of breast cancer in this region.

Cited by 9 publications

References 22 publications

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Negative Association of the HLA-DQB1^*02 Allele with Breast Cancer Development among Jordanians

Association between HLA‐DQA1, HLA‐DQB1 and oral cancer

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HLA-DQA1 and -DQB1 allele typing in southern Taiwanese women with breast cancer

Abstract: We have established a significant lack of HLA-DQA1 and -DQB1 association with breast cancer in southern Taiwanese women. The results of this study may provide information for further clarification of the etiology of breast cancer in this region.

Cited by 9 publications

References 22 publications

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan

Negative Association of the HLA-DQB1*02 Allele with Breast Cancer Development among Jordanians

Association between HLA‐DQA1, HLA‐DQB1 and oral cancer

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Negative Association of the HLA-DQB1^*02 Allele with Breast Cancer Development among Jordanians