HLA‐DRw Antigens Associated with Acute Leukemia

Fliedner, Vladimir E. Von; Sultan-Khan, Z; Jeannet, M

doi:10.1111/j.1399-0039.1980.tb00321.x

Cited by 27 publications

(6 citation statements)

References 15 publications

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“…This may suggest a role for DRB1*07 allele in the development of CLL. Although we and others reported an increased frequency of DRB1*07 in CLL patients, conflicting results have been reported in ALL [31,32], CML [33], and Burkitt's lymphoma [34]. The frequency of DRB1*13 was also higher in our CLL patients, whereas the frequencies of DRB1*11, DRB1*15, DRB1*04, and DRB1*09 were higher in normal controls, although the frequency of none of these alleles reached statistical significance.…”

Section: Discussionmentioning

confidence: 85%

Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

et al. 2008

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Section: Discussionmentioning

confidence: 85%

Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

et al. 2008

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“…These studies showed that HLA-Cw3 and -Cw4 are both susceptibility markers for all the three major leukemia. HLA-DR studies in childhood ALL showed an increase for HLA-DR7 [17][18][19]. In one study, adult ALL showed a weak association with HLA-DRB1 *04 [27] and in another CLL was associated with HLA-DRB4*01 [28].…”

mentioning

confidence: 99%

HLA-A, -B, -DRB1 alleles and haplotypes frequencies in Moroccan patients with leukemia

Kabbaj

Oudghiri²,

Naya³

et al. 2010

Annales De Biologie Clinique

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Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. In Moroccan leukemic patients, the frequency of HLA alleles has not already been determined. We have analyzed HLA class I and class II alleles and haplotypes in 62 Moroccan leukemic patients and 98 unrelated normal subjects using PCR-SSO method. Significant positive association with the disease, in patients compared to controls, was found for three alleles: HLA-B*44 (12.7% vs 6.6%; p = 0.02), HLA-DRB1*13 (11.8% vs 9.79%; p = 0.04) and HLA-DRB *01 (4.5% vs 10.7%; p = 0.05). Regarding haplotypes analysis, no significant association was found between patients and control groups. It is suggested that HLA-B*44 and HLA-DRB1*13 alleles may play a presumptive predisposing factor while the HLA-DRB*01 allele could be a protective genetic factor against leukemia.Résumé. L'implication du système HLA dans le développement des leucémies ainsi que la susceptibilité et/ou la résistance à la maladie ont été largement étudiées dans diverses ethnies. Dans notre étude, les fréquences alléliques du système HLA de classe I et de classe II ont été analysées chez un groupe de patients leucémiques marocains. Tous ces cas ont été colligés au laboratoire d'immuno-histocompatibilité de l'Institut Pasteur du Maroc, et comparés à un groupe d'individus contrôle de donneurs sains de même ethnie. Le typage des antigènes HLA classe I (A et B), et classe II (DRB1) pour l'ensemble des patients a été réalisé par biologie moléculaire (PCR-SSO). L'analyse statistique des résultats obtenus (patients versus groupe contrôle sain), a montré d'une part, la forte expression de certains allèles, citons : HLA-B*44 (12,7 % vs 6,6 % ; p = 0,02) et HLA-DRB1*13 (11,8 % vs 9,79 % ; p = 0,04) et, d'autre part, la diminution de la fréquence aléllique du HLA-DRB1*01 (4,5 % vs 10,7 % ; p = 0,05). Ceci semble être en faveur d'une association statistiquement significative entre les différents types de leucémie et le système HLA. Par ailleurs, l'analyse des haplotypes HLA entre la population des malades et les contrôles n'a montré aucune association significative. Ces résultats suggèrent que les allèles HLA-B*44, HLA-DRB1*01 et HLA-DRB1*13 seraient associés aux différents types de leucémies chez les patients marocains, ce qui peut être en faveur soit d'une prédisposition soit d'une résistance à la leucémie. De plus larges études sont nécessaires pour décrire et confirmer le rôle de ces associations avec cette pathologie.

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“…Additional evidence specifically in childhood ALL was available shortly after based on studies by Von Fliedner et al, one of which confirmed the DR7 association (35) and the other showing a higher than expected sharing of DR antigens among parents of children with leukemia (26). …”

Section: Classical Hla Genesmentioning

confidence: 94%

“…Suggestion of a putative role of the HLA class II DR antigen on ALL risk was first reported in the late 1970s ( 34 ) and showed an association with DR7. Additional evidence specifically in childhood ALL was available shortly after based on studies by Von Fliedner et al, one of which confirmed the DR7 association ( 35 ) and the other showing a higher than expected sharing of DR antigens among parents of children with leukemia ( 26 ).…”

Section: Classical Hla Genesmentioning

confidence: 94%

Genetic Variation in the Extended Major Histocompatibility Complex and Susceptibility to Childhood Acute Lymphoblastic Leukemia: A Review of the Evidence

et al. 2013

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The enduring suspicion that infections and immunologic response may play a role in the etiology of childhood leukemia, particularly acute lymphoblastic leukemia (ALL), is now supported, albeit still indirectly, by numerous epidemiological studies. The cumulative evidence includes, for example, descriptive observations of a peculiar peak incidence at age 2–5 years for ALL in economically developed countries, clustering of cases in situations of population mixing associated with unusual patterns of personal contacts, associations with various proxy measures for immune modulatory exposures early in life, and genetic susceptibility conferred by variation in genes involved in the immune system. In this review, our focus is the extended major histocompatibility complex (MHC), an approximately 7.6 Mb region that is well-known for its high-density of expressed genes, extensive polymorphisms exhibiting complex linkage disequilibrium patterns, and its disproportionately large number of immune-related genes, including human leukocyte antigen (HLA). First discovered through the role they play in transplant rejection, the classical HLA class I (HLA-A, -B, and -C) and class II (HLA-DR, HLA-DQ, and HLA-DP) molecules reside at the epicenter of the immune response pathways and are now the targets of many disease susceptibility studies, including those for childhood leukemia. The genes encoding the HLA molecules are only a minority of the over 250 expressed genes in the xMHC, and a growing number of studies are beginning to evaluate other loci through targeted investigations or utilizing a mapping approach with a comprehensive screen of the entire region. Here, we review the current epidemiologic evidence available to date regarding genetic variation contained within this highly unique region of the genome and its relationship with childhood ALL risk.

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HLA‐DRw Antigens Associated with Acute Leukemia

Cited by 27 publications

References 15 publications

Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

HLA-A, -B, -DRB1 alleles and haplotypes frequencies in Moroccan patients with leukemia

Genetic Variation in the Extended Major Histocompatibility Complex and Susceptibility to Childhood Acute Lymphoblastic Leukemia: A Review of the Evidence

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