HLA-G is associated with pemphigus vulgaris in jewish patients

Gazit, Ephraim; Slomov, Yelena; Goldberg, Ilan; Brenner, Sarah; Loewenthal, Ron

doi:10.1016/j.humimm.2003.09.019

Cited by 86 publications

(78 citation statements)

References 57 publications

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“…Further genotyping of Jewish patients and controls for HLA-G polymorphisms revealed significant differences in the 14-bp ins/del polymorphism [88]. On the other hand, no differences in the 14-bp polymorphism were observed between psoriatic patients and controls in a recent Italian study [89].…”

Section: Hla-g Polymorphism and Autoimmune Diseasementioning

confidence: 85%

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Larsen

Hviid

2009

Human Immunology

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Section: Hla-g Polymorphism and Autoimmune Diseasementioning

confidence: 85%

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Larsen

Hviid

2009

Human Immunology

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“…Most studies concern the Mediterranean Basin or Asia Minor (Bulgaria, Macedonia, Turkey, Israel, Iran, Tunisia and Greece) [1,2,4,5,6,7,8]. The crude incidence of auto-immune pemphigus in the world varies from 0.8 to 34/10 6 inhabitants [9,10,11,12,13]. Few studies have been performed with individual validation of the cases and calculation of the standardized incidence of the pemphigus.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

et al. 2009

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Introduction: Auto-immune pemphigus is an organ-specific immune disorder due to pathogenic auto-antibodies. Both genetic and environmental factors have been associated with the occurrence of auto-immune pemphigus. Little is known about the epidemiology of auto-immune pemphigus in western Europe. Objective: To evaluate the incidence of auto-immune pemphigus in south-western France (namely the Midi-Pyrénées region) in a 5-year period between 2002 and 2006. Materials and Methods: We performed a retrospective study of the annual incidence of auto-immune pemphigus diagnosed in the Midi-Pyrénées region, between January 1, 2002, and December 31, 2006. Possible cases of pemphigus were initially selected using skin direct immunofluorescence (DIF) databases from all laboratories in the Midi-Pyrénées region. Systematic validation of all cases was performed by two of the authors (N.M., M.T.). To qualify as a case of auto-immune pemphigus, patients had to fulfil the following criteria: history of clinical signs of pemphigus as assessed by a dermatologist and a positive DIF. To be included in the study, validated cases of auto-immune pemphigus had to fulfil the following criteria: the date of first positive skin DIF between January 1, 2002, and December 31, 2006, and patient living in the Midi-Pyrénées region at the time of the first positive skin DIF. Results: Between 2002 and 2006, 91 patients with positive DIF were identified. Fifty-four patients with positive DIF did not meet the validation criteria for the study. Thirty-seven cases were included in the analysis. The crude annual mean incidence of auto-immune pemphigus between 2002 and 2006 was 2.7 cases/10⁶ inhabitants/year (95% CI: 1.87–3.69). The world-population-standardized annual mean incidence of auto-immune pemphigus was 1.55 (95% CI: 0.99–2.11). Conclusion: We report a 1.55/10⁶ inhabitants/year world-population-standardized incidence of auto-immune pemphigus in the south-west of France. A nationwide epidemiological study of pemphigus should be performed in France.

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“…Both studies showed consistent results: there was no difference between genotype and allelic frequencies for this polymorphism. A single study for each of the associations between this polymorphism and JIR, multiple sclerosis, ulcerative colitis, Crohn's disease, idiopathic dilated cardiomyopathy, pemphigus vulgaris, and non-segmental vitiligo has been reported (Gazit et al, 2004;Glas et al, 2007;Kroner et al, 2007;Lin et al, 2007;Veit et al, 2008;Jeong et al, 2014). Thus, we did not perform AID subtype analyses of these cases, and the results should be interpreted cautiously.…”

Section: Discussionmentioning

confidence: 97%

Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis

Sk¹,

Jeong²,

Ij³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and EMBASE databases was conducted to identify eligible studies investigating the association of the HLA-G 14-bp INS/DEL polymorphism with AID. Our analysis included 11 publications involving a total of 6462 individuals. Overall, no significant association between the HLA-G 14-bp INS/DEL polymorphism and AID was detected in any comparison model. Further subgroup analyses based on AID types and ethnicity also revealed no significant associations. Our results suggest that the HLA-G 14-bp INS/DEL polymorphism is unrelated 15839-15847 (2015) to the development of AID. Further studies including larger sample sizes are warranted to confirm these results.

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HLA-G is associated with pemphigus vulgaris in jewish patients

Cited by 86 publications

References 57 publications

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis

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