Hodgkin's Disease: Retrospective clinico-pathologic study in 149 patients

Landberg, T.; Larsson, Lars‐Erik

doi:10.3109/02841866909134467

Cited by 23 publications

(6 citation statements)

References 21 publications

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“…Since the survival rate of Stage 1-2 and I1 were very close, Carbone et al (1971) had recommended that the old Rye Stage 1-2 should be combined with Stage 11. with nodular sclerosis had the best prognosis and those with lymphocytic depletion, the poorest. Many other authors (Chawla et al, 1970;Franssila et al, 1967;Fuller et al, 1971;Cough, 1970;Hamann et al, 1970;Keller et al, 1968;and Landberg and Larsson, 1969) observed that a highly significant correlation exists between the survival rate and different histological types and between age and histological types (Newell et al, 1970).…”

Section: Discussionsupporting

confidence: 79%

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Prognostic factors in Hodgkin's disease

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Lee

Hori

et al. 1975

Journal of Surgical Oncology

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The clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of radiotherapy and chemotherapy. Statistical studies were carried out in order to evaluate the independent prognosis significance of each of these factors. All of the lesions were reclassified according to the Lukes proposal which was modified and recommended at the 1965 Rye classification (except for hepatomegaly which was included in Stage IV). This is a retrospective study, and the modern techniques of staging were rarely used in pretreatment studies (since 1965, only ten patients have had an abdominal exploration). The basic work-up consisted of a complete blood count, urinalysis, blood type, chest X ray, and EKG. Lymphangiogram and radioisotope liver scans were used on less than 10% of the patients. About 30% of the patients had gastrointestinal X rays and 70% had IVP. Bone marrow biopsies -- the majority of which were done by needle aspiration -- were obtained for approximatley 50% of the patients. Clinical stage, histological type, and presence of absence of systemic symptoms appeared to be themost significant prognostic factors. The classification of systemic symptoms according to the criteria of either the Rye or Ann Arbor conferences showed no particular difference in determining the survival rate. Among the systemic symptoms, fever appeared to be the most important for survival rate. Survival rates were higher in nonanemic and nonlymphocytopenic patients. Eosinophilia, blood group, and Rh factor had no prognostic significance. The relapse-free interval was an important indicator of long-term prognosis. The unfavorable influence of relapse in ultimate prognosis was clearly seen; however, the extent of the relapse site was shown to have no significant influence on survival.

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Section: Discussionsupporting

confidence: 79%

“…Most authors (Chawla et al, 1970;Kaplan, 1970;Landberg and Larsson, 1969;Musshoff and Boutis, 1968;Peters, 1950;and Westling, 1965) …”

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confidence: 99%

Prognostic factors in Hodgkin's disease

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Lee

Hori

et al. 1975

Journal of Surgical Oncology

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“…As such factors may determine the prognosis of the disease, knowledge about the composition of the materials is essential for comparison of the results of treatment. In Table 6 some information of prognostic importance from our patient material is compared with the material from Denmark (LYGRA project 1976); South Sweden (Landberg & Larsson 1969; Norway (Host 1977); Stanford, California (Kaplan 1973). 50 % of our patients were classified as MC and LD (39 and 11 % respectively).…”

Section: Lymphangiographymentioning

confidence: 99%

Prognostic Factors in Hodgkin's Disease

Björkholm

Holm

Mellstedt

et al. 1977

Scandinavian Journal of Haematology

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An unselected material of 83 consecutive and previously untreated adult patients with Hodgkin's disease (HD) from the Stockholm area is presented. The distribution of patients according to age was characteristically bimodal. The histopathological subtypes were 16 % lymphocyte predominance (LP), 33 % nodular sclerosis (NS), 37 % mixed cellularity (MC) and 11 % lymphocyte depletion (LD). The patients were treated with aggressive megavoltage irradiation and multidrug chemotherapy. Major factors affecting prognosis were age, clinical stage and constitutional symptoms. Patients with LP and NS subtypes had only slightly better prognosis than patients classified as MC and LD. The overall survival was 68 % at 4½ years, which is close to that reported from other groups with similar composition of their materials with regard to age, histopathology and stage.

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“…In Dorfman's series [l] of 185 patients, only three (1.6%) had epitrochlear adenopathy during their illness. Of the 149 patients reported by Landberg and Larsson [2,3], two had involvement of epitrochlear nodes. By comparison, involvement of the epitrochlear nodes by nodular lymphoma, particularly as a site of relapse, has been reported in 23 % of patients [9].…”

Section: Introductionmentioning

confidence: 99%

“…Cervical and supraclavicular nodes are most commonly involved, followed in frequency by axillary and mediastinal nodes [2,8].…”

Section: Introductionmentioning

confidence: 99%

Hodgkin's disease presenting in epitrochlear nodes

Steinfeld

1984

Med. Pediatr. Oncol.

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Two cases of Hodgkin's Disease (HD) presenting in epitrochlear nodes are described, and compared to four similar cases gleaned from the literature. The nodular sclerosis type of HD was present in 5 of the 6 patients. Of the four patients staged with laparotomy, two had infradiaphragmatic disease. A treatment approach using radiation alone for patients with disease limited to the epitroclear region is presented, and anatomical considerations of the treatment technique are given.

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Hodgkin's Disease: Retrospective clinico-pathologic study in 149 patients

Cited by 23 publications

References 21 publications

Prognostic factors in Hodgkin's disease

Prognostic factors in Hodgkin's disease

Prognostic Factors in Hodgkin's Disease

Hodgkin's disease presenting in epitrochlear nodes

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