Hodgkin’s lymphoma and its association with EBV and HIV infection

Grewal, Ravnit; Irimie, Alexandra Iulia; Naidoo, Nasheen; Mohamed, Nooroudien; Petrushev, Bobe; Chetty, Manogari; Tomuleasa, Ciprian; Abayomi, E. A.

doi:10.1080/10408363.2017.1422692

Cited by 25 publications

(13 citation statements)

References 106 publications

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“…Moving away from the clinical implications, it also must be considered that formalin-fixed paraffin embedded (FFPE) samples can be stored for longer, therefore ensuring that retrospective studies can be conducted when compared to flow cytometry. Thus, whilst histology remains the recommended tool for accurate diagnosis of lymphoma, flow cytometry does aid in quick assessments, especially when the clinical presentation requires immediate results [32][33][34][35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Griesel

Desmirean

Esterhuizen

et al. 2020

JCM

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Introduction: Fine needle aspiration (FNA) is frequently the first noninvasive test used for the diagnostic workup of lymphadenopathy. There have been many studies showing its usefulness, especially in conjunction with other techniques for the diagnosis of lymphoma, but it remains inferior to histological examination. The data regarding this subject have mostly been reported mostly from first-world countries, but are scarce for emerging economies. Thus, the current study assesses the agreement between fine needle aspiration flow cytometry (FNA FC) and histology in the aforementioned region. Material and Methods: We conducted a retrospective study including the FNA FC adenopathy diagnoses made between January 2011 and December 2016 at the Tygerberg Hospital, Cape Town, South Africa. Additional variables included were the histological diagnosis, sex and age of the included patients. Results: In the descriptive part of the current study, 269 FNA FC samples were included. The most frequent diagnoses made on these were represented by B-cell lymphoma, reactive adenopathy, no abnormality detected (NAD), and non-hematological malignancy. In the analytical part of the current study, there were 115 cases included that had both valid FNA FC and histological diagnoses. It could be observed that FNA FC can correctly diagnose B-cell lymphoma in most cases, but it is a poor diagnostic tool especially for Hodgkin lymphoma in this setting as only a four-color flow cytometer was available for diagnosis. Moreover, FNA FC diagnosis of reactive adenopathy and of no abnormalities detected was shown to frequently hide a malignant disease. Conclusion: In countries with scarce resources, FNA FC represents a useful diagnostic tool in the case of B-cell lymphoma, but may misdiagnose reactive adenopathy. Thus, FNA FC should be used in a case-specific manner, in addition to as a screening tool, with the knowledge that in cases with a high clinical suspicion of lymphoma, histological diagnosis is a necessity.

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Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Griesel

Desmirean

Esterhuizen

et al. 2020

JCM

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“…CD3+/CD4+/CD8− shows a less aggressive type of PTCL-NOS, as compared with CD8 strongly positive PTCL-NOS. An aggressive type of PTCL-NOS is also characterized by positivity for granzyme B [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Clinical Remission in a 72-Year-Old Patient with a Massive Primary Cutaneous Peripheral T-Cell Lymphoma-NOS of the Eyelid, Following Combination Chemotherapy with Etoposide Plus COP

et al. 2020

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Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is the rarest subtype of primary cutaneous lymphoma, accounting for approximately 2% of cutaneous lymphomas. The rarity of primary cutaneous PTCL-NOS means that there is a paucity of data regarding clinical and histopathological features and its clinical course. This malignancy is an aggressive and life-threatening hematological malignancy that often presents mimicking other less severe plaque-like skin conditions. Due to the nonspecific nature of these lesions, CD4-positive cutaneous T-cell lymphoma (CTCL) is often misdiagnosed as either mycosis fungoides or Sezary syndrome. We describe a patient who presented with a large tumoral mass in the right frontal area, with involvement of the right upper eyelid and the ocular globe, causing loss of vision greatly impacting the quality of life. Biopsy revealed primary cutaneous PTCL-NOS, treated successfully with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus etoposide combination chemotherapy. As elderly patients are indicated to receive attenuated doses of chemotherapy, CHOP-based regimens represent viable options.

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“…The diagnosis procedure is complex and is built around the histology of the lymphoma and of the aberrant expression of CD20. Thus, the differential diagnosis for lymphoma was established taking into consideration angioimmunoblastic lymphoma, Lennert’s lymphoma and a peripheral T cell lymphoma, NOS [11–13]. The diagnosis of a peripheral T-cell lymphoma, NOS is confirmed by the absence of a more prominent network of vascular structures, with thick hyaline fibers, as well as due to the negative staining of the malignant cells for CD10, corroborated with the paucity of hyperplastic follicular dendritic cells.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic hypereosinophilia in a patient with peripheral T cell lymphoma, not otherwise specified

Desmirean

Deak

Rus

et al. 2019

Medicine and Pharmacy Reports

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Under normal physiological conditions, the bone marrow (BM) will have between 1% and 6% eosinophils, translating into a peripheral count of 0.05 – 0.5 ×109/L eosinophils in the blood smear. This process is coordinated by transcription factors with specific roles in differentiation and activation. Secondary eosinophilia may be a paraneoplastic syndrome, related to the presence of a subsequent malignancy, as presented in this case report. Such paraneoplastic manifestations should be addressed properly in order for the patient to receive the best treatment of choice. Even if eosinophilia was associated with B-cell malignancies before, this is a report associating this symptom to a peripheral T-cell lymphoma, not other specified, thus emphasizing the importance of a complex approach for the management of the oncological patient.

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Hodgkin’s lymphoma and its association with EBV and HIV infection

Cited by 25 publications

References 106 publications

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Differential Diagnosis of Malignant Lymphadenopathy Using Flow Cytometry on Fine Needle Aspirate: Report on 269 Cases

Clinical Remission in a 72-Year-Old Patient with a Massive Primary Cutaneous Peripheral T-Cell Lymphoma-NOS of the Eyelid, Following Combination Chemotherapy with Etoposide Plus COP

Paraneoplastic hypereosinophilia in a patient with peripheral T cell lymphoma, not otherwise specified

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