Hofmeister series: An insight into its application on gelatin and alginate-based dual-drug biomaterial design

Das, Sougat; Giri, Lopamudra; Majumdar, Saptarshi

doi:10.1016/j.eurpolymj.2023.111961

Cited by 15 publications

(11 citation statements)

References 51 publications

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“…The chaotropic anions have a smaller hydration radius and greater mobility, allowing them to easily diffuse into the gelatin chains and screen the charges more effectively. [38] On the other hand, kosmotropes have a higher number of positive charges on the gelatin chains because they are unable to screen them due to their larger hydrodynamic radius, lower mobility, and repulsions from the amide bonds of gelatin. [55] As a result, there are more positively charged amines available for interaction with kosmotropes.…”

Section: Drug Release and Swelling/degradation Resultsmentioning

confidence: 99%

“…The author's previous publication emphasised the effect of these salts on the liquid-based gelatin alginate dual drug formulations. [38] This article emphasises the effect of different Hofmeister salts and their mixtures on the gelatin-alginate cross-linker-free hydrogels for the delivery of naproxen. This study considers two kosmotropes (Na 2 SO 4 and CH 3 COONa) and two chaotropes (NaCl and NaNO 3 ) to study the same.…”

Section: Introductionmentioning

confidence: 99%

“…This range of salts modulates the physical interactions between the polymers, resulting in changes in the properties of the prepared hydrogels. The author's previous publication emphasised the effect of these salts on the liquid‐based gelatin alginate dual drug formulations [38] . This article emphasises the effect of different Hofmeister salts and their mixtures on the gelatin‐alginate cross‐linker‐free hydrogels for the delivery of naproxen.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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The cross‐linker‐free hydrogels have gained attention due to their lack of need for chemically modified polymers, resulting in better biocompatibility. The hydrogel properties can be enhanced by altering physical forces such as electrostatics and H‐bonds. Tuning the physical interactions between polymers, salts, and plasticisers can unlock new horizons in material properties. This article examines four different salts and mixtures to determine their impact on gelatin‐alginate biomaterial design. Drug release, swelling, and rheological properties are represented using a 3‐D plot, and optimum samples are identified. It is concluded that kosmotropes yield better release and swelling results than chaotropes. The physical interactions of these salts with polymers are explained using DLS and FTIR/ATR studies, and these findings are corroborated with release, swelling, and rheological analyses. Another aspect of the biomaterial, self‐healing property, is also considered. A 3‐D plot is prepared using release kinetics, gel strength, and recovery percentage (three important factors for self‐healing hydrogels). Chaotropes are identified as better candidates for self‐healing behaviour. However, when considering gel strength, release, and self‐healing, kosmotropes are favourable. Hence, different salts can be selected based on the desired application for hydrogels. It is also concluded that electrostatic forces hinder the formation of H‐bonds between polymer chains.

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Section: Drug Release and Swelling/degradation Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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“…This would allow one not only to determine protein stability or aggregation in the presence of different salt, but also to design biomaterials of customized characteristics. 15,16 Thus, investigating ion-protein/ion-RNA interaction under specific conditions is crucial to understand disease mechanisms and possible therapeutic measures.…”

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confidence: 99%

Unraveling fluctuation in gelatin and monovalent salt systems: coulombic starvation

2023

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“…Salts are broadly classified into two categories: kosmotropes and chaotropes. Kosmotropes (K 2 SO 4 , KH 2 PO 4 , and CH 3 COOK) lead to precipitation, and chaotropes (KCl, KBr, and KNO 3 ) lead to the solvation of proteins, respectively. − The phase-separation/precipitation of proteins occurs at high salt concentrations due to the higher ionic strength induced by salts …”

mentioning

confidence: 99%

Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

Das,

Basu,

Majumdar

2023

ACS Macro Lett.

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Hydration of the protein/polymer is the most important aspect of stability. It is well-known that salts alter the charged polymer's electrostatic forces, ultimately impacting its conformations in solution. The solvent effects lead to certain conformational fluctuations. Previous studies have shown the screening of electrostatic repulsion within the charge-imbalanced protein following charge inversion owing to counterion condensation and phase separation. This article studies conformation stability and phase separation of charge-balanced gelatin (a protein polymer at the isoelectric point) with the addition of different salts. A phenomenon has been reported where the electrostatic effect of salts results in conformational fluctuations in gelatin due to its insufficient hydrations (termed as starvation), which scales with salt concentration. This article also presents different transition states for charge-balanced proteins prior to phase separation. It is concluded that phase separation of a charge-balanced protein passes through a stable state followed by an unstable transition state, where certain unique interactions with salts occur.

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Hofmeister series: An insight into its application on gelatin and alginate-based dual-drug biomaterial design

Cited by 15 publications

References 51 publications

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Unraveling fluctuation in gelatin and monovalent salt systems: coulombic starvation

Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

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