Hollow Porous Polymeric Nanospheres of a Self-Enhanced Ruthenium Complex with Improved Electrochemiluminescent Efficiency for Ultrasensitive Aptasensor Construction

Chen, Anyi; Zhao, Min; Zhuo, Ying; Chai, Yaqin; Yuan, Ruo

doi:10.1021/acs.analchem.7b02003

Cited by 71 publications

(52 citation statements)

References 40 publications

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“…Recently, we developed a self-enhanced ECL emitter by synthesizing a kind of hollow multihole polymeric nanosphere, which decreased the inner filter effect of the bulk nanomaterials and achieved the enhancement on ECL efficiency. 19 However, the materials preparation was uncontrollable due to the successive wrapping of polyelectrolyte on SiO 2 nanoparticles. More importantly, the low space utilization of the hollow structure caused the decrease of loading capacity to limit the improvement of ECL signal.…”

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confidence: 99%

“…Since Bard’s group reported the first ECL study on quantum dots (QDs), miscellaneous nanomaterials were extensively applied as ECL emitters. − Although these nanomaterials have the advantages of excellent immobilization capacity, the dense nanomaterials caused a serious inner filter effect to reduce the ECL efficiency. Recently, we developed a self-enhanced ECL emitter by synthesizing a kind of hollow multihole polymeric nanosphere, which decreased the inner filter effect of the bulk nanomaterials and achieved the enhancement on ECL efficiency . However, the materials preparation was uncontrollable due to the successive wrapping of polyelectrolyte on SiO 2 nanoparticles.…”

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confidence: 99%

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Three-Dimensional Cadmium Telluride Quantum Dots–DNA Nanoreticulation as a Highly Efficient Electrochemiluminescent Emitter for Ultrasensitive Detection of MicroRNA from Cancer Cells

et al. 2019

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In this work, a novel three-dimensional cadmium telluride quantum dots–DNA nanoreticulation (3D CdTe QDs–DNA-NR) was used as a signal probe with the dual-legged DNA walker circular amplification as target conversion strategy to establish a pioneering electrochemiluminescence (ECL) biosensing strategy for ultrasensitive detection of microRNA-21 form cancer cells. Herein, such a 3D luminous nanomaterial with reticular structure not only supported abundant CdTe QDs to avoid the inner filter effect for obtaining a high ECL efficiency but also contained the hemin/G-quadruplex as coreaction accelerator in the 3D CdTe QDs–DNA-NR/S2O8 2– system for the enhancement of ECL intensity. Furthermore, with the target-induced dual-legged DNA walker circular amplification strategy, a mass of output DNA was produced to connect with the 3D CdTe QDs–DNA-NR for the construction of the ECL biosensor, which realized the ultrasensitive detection of microRNA-21 from 100 aM to 100 pM and the detection limit down to 34 aM. Significantly, this work could be readily extended for the detection of other biomolecules to provide a neoteric channel for disease diagnosis.

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Three-Dimensional Cadmium Telluride Quantum Dots–DNA Nanoreticulation as a Highly Efficient Electrochemiluminescent Emitter for Ultrasensitive Detection of MicroRNA from Cancer Cells

et al. 2019

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“…Meanwhile, the CV response and ECL−potential profile of the Zr‐TCBPE‐PEI‐Ag NPs are shown in Figure S8C (Supporting Information). On the basis of previous reports, [ 45,46 ] the speculated mechanism for the intramolecular self‐catalytic ECL system was listed as the following equations:

\begin{matrix} Zr - TCBPE - PEI - 2 {normale}^{-} \to Zr - {TCBPE}^{+} - {PEI}^{• +} \end{matrix}

\begin{matrix} Zr - {TCBPE}^{+} - {PEI}^{• +} \to Zr - {TCBPE}^{+} - {PEI}^{•} + {normalH}^{+} \end{matrix}

\begin{matrix} Zr - {TCBPE}^{+} - {PEI}^{•} \to Zr - {TCBPE}^{*} - PEI \end{matrix}

\begin{matrix} Zr - {TCBPE}^{normal*} - PEI \to Zr - TCBPE - PEI + hv \end{matrix}

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Section: Resultsmentioning

confidence: 99%

“…Generally, the ECL emission efficiency of luminophor would play a key role in improving the sensitivity of constructed On the basis of previous reports, [45,46] the speculated mechanism for the intramolecular self-catalytic ECL system was listed as the following equations:…”

Section: Biosensing Applicationmentioning

confidence: 99%

Dumbbell Plate‐Shaped AIEgen‐Based Luminescent MOF with High Quantum Yield as Self‐Enhanced ECL Tags: Mechanism Insights and Biosensing Application

Jia

Ren

et al. 2022

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low background interference, and easy operation. [4][5][6][7] Nowadays, ECL with these favorable benefits has become one powerful analytical technique applied in biomarkers, food safety, and environmental pollutants analyses. [8][9][10][11] As it is well known, the high sensitivity for the ECLbased immunoassays was mainly attributable to the excellent luminophores. [12] At present, most of the reported methods used nanomaterials like multi-porous nanoparticles (NPs) [13,14] or metal−organic frameworks (MOFs) [15][16][17] as carriers to immobilize the typical ECL emitters, including luminol, tris-bipyridyl ruthenium (Ru(bpy) 3 2+), and their derivatives. [1] In particular, MOFs have received intense attention in ECL analysis because of their high poriness, easy functionalization, and ultrahigh surface area. [18][19][20] Nonetheless, these nanomaterials based strategies for luminophores immobilization by postmodification or encapsulation, still exist some shortcomings when used in aqueous phase. For instance, the poor stability of MOFs in water would result in leakage of ECL chromophores, and the large steric hindrance of organic luminophores limited the loading capacity to some extent, which both abridged their in-depth application in ECL bioassays. Thus, without the trivial post-synthetic steps, it seems an ideal way to design innovative ECL luminophores based MOFs that emitted light by themselves.Currently, some groups have reported that the Ru(bpy) 3 2+ derivatives, could be employed as organic ligands to fabricate MOFs with self-luminescent properties. [21,22] To some extent, the aggregation-caused quenching (ACQ) effect [23,24] was unavoidable due to the π-π stacking of the aggregated luminescent centrosome. Fortunately, aggregation-induced emission (AIE), which was proposed by Tang and co-workers in 2001, [25] paved a new avenue to resolve this problem. So far, a variety of AIE luminogens (AIEgens)-based nanomaterials have been widely applied in the fields of solid-state optoelectronic devices, [26,27] fluorescence imaging, [28] and biosensors, [29][30][31] because the AIEgens displayed strong emission in aggregated state but almost nonemissive in diluted solution with molecule-free state. [32] Inis widely known that high-performance electrochemiluminescence (ECL) emitters play a crucial part in improving the detection sensitivity of the ECL strategy. Through the combination of aggregation-induced emission luminogens (AIEgens), 1,1,2,2-tetra(4-carboxylbiphenyl)ethylene (H 4 TCBPE) with Zr(IV) cations, a dumbbell plate-shaped metal−organic framework (MOF) with high luminous efficiency is synthesized as ECL tags. The resultant MOF exhibits stronger ECL activity than those of H 4 TCBPE monomers and aggregates. Herein, this phenomenon is defined as the coordination-triggered electrochemiluminescence (CT-ECL) enhancement effect. Furthermore, the nearly matched ECL and photoluminescence (PL) spectra imply the bandgap emission mechanism. Remarkably, polyethyleneimine (PEI) as the coreactant is covalently connected ...

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“…4 However, the involvement of nanomaterials might cause the potential problems of (i) ECL quenching owing to the energy transfer between AuNPs and Ru(bpy) 3 2+ , 5 and (ii) poor ECL efficiency of the internal ECL lumiphore. 6 More importantly, ECL intensity does not always increase linearly with amount of Ru(bpy) 3 2+ ; thus only enriching the amount of Ru(bpy) 3 2+ will lead to bottlenecks in achieving enhanced ECL intensity. 7 Herein, we note that the TPrA radical (TPrAc) can also play a crucial role in boosting the ECL emission of Ru(bpy) 3 2+ , since the excited states of Ru(bpy) 3 2+ are generated through the interaction between the active intermediates of Ru(bpy) 3 2+ and TPrAc.…”

Section: Introductionmentioning

confidence: 99%

Covalent organic frameworks as micro-reactors: confinement-enhanced electrochemiluminescence

et al. 2020

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Hollow Porous Polymeric Nanospheres of a Self-Enhanced Ruthenium Complex with Improved Electrochemiluminescent Efficiency for Ultrasensitive Aptasensor Construction

Cited by 71 publications

References 40 publications

Three-Dimensional Cadmium Telluride Quantum Dots–DNA Nanoreticulation as a Highly Efficient Electrochemiluminescent Emitter for Ultrasensitive Detection of MicroRNA from Cancer Cells

Three-Dimensional Cadmium Telluride Quantum Dots–DNA Nanoreticulation as a Highly Efficient Electrochemiluminescent Emitter for Ultrasensitive Detection of MicroRNA from Cancer Cells

Dumbbell Plate‐Shaped AIEgen‐Based Luminescent MOF with High Quantum Yield as Self‐Enhanced ECL Tags: Mechanism Insights and Biosensing Application

Covalent organic frameworks as micro-reactors: confinement-enhanced electrochemiluminescence

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