Homeostasis, regeneration and tumour formation in the mammalian epidermis

Belokhvostova, Daria; Berzanskyte, Ieva; Cujba, Ana-Maria; Jowett, Geraldine M.; Marshall, Lucy R.; Prueller, Johanna; Watt, Fiona M.

doi:10.1387/ijdb.170341fw

Cited by 39 publications

(36 citation statements)

References 107 publications

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“…The skin epithelium renews throughout life in a continuous turnover ensured by stem and progenitor cells that balance proliferation and differentiation to replace dead and terminally differentiated cells 1,13,14 . Epithelial stem cells reside in a specific microenvironment called niche that is composed of a variety of cell types.…”

Section: Skin Epithelial Stem Cells During Homeostasis [H1]mentioning

confidence: 99%

“…Niche cells influence stem cell behaviour directly by cell contact or indirectly via ECM components and growth factors 15 . Although skin stem cells are able to regenerate the entire repertoire of skin epithelial lineages upon transplantation, lineage tracing has demonstrated that during physiological conditions, epidermal compartments are sustained by their own pool of resident stem cells [14][15][16] (Fig. 2a).…”

Section: Skin Epithelial Stem Cells During Homeostasis [H1]mentioning

confidence: 99%

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Stem cell dynamics, migration and plasticity during wound healing

2019

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Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other cell types including fibroblasts and immune cells is required to ensure efficient and harmonious wound healing. A complex crosstalk ensures the activation, migration and plasticity of these cells during tissue repair.

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Section: Skin Epithelial Stem Cells During Homeostasis [H1]mentioning

confidence: 99%

Section: Skin Epithelial Stem Cells During Homeostasis [H1]mentioning

confidence: 99%

Stem cell dynamics, migration and plasticity during wound healing

2019

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“…While the two principles are not mutually exclusive, an intrinsic niche is perhaps particularly suitable in the context of large SC populations that need to homogeneously generate progeny cells over extended distances, such as NSC niches or the interfollicular SC population in the adult mammalian skin (Belokhvostova et al, 2018;Blanpain and Fuchs, 2009). Interestingly, in the latter case, a recent study using intravital imaging showed that neighboring SCs coordinate their fate decisions to differentiate and divide (Mesa et al, 2018).…”

Section: Lineage-derived Inhibitory Feedbacks Generate An Intrinsic Nmentioning

confidence: 99%

Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

Dray

Mancini

Binshtok

et al. 2020

Preprint

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SUMMARYNeural stem cell (NSC) populations persist in the adult vertebrate brain over a life time, and their homeostasis is controlled at the population level. The nature and properties of these coordination mechanisms remain unknown. Here we combine dynamic imaging of entire NSC populations in their in vivo niche over weeks, pharmacological manipulations, mathematical modeling and spatial statistics, and demonstrate that NSCs use spatiotemporally resolved local feedbacks to coordinate their decision to divide. These involve a Notch-mediated inhibition from transient neural progenitors, and a dispersion effect from dividing NSCs themselves, exerted with a delay of 9-12 days. Simulations from a stochastic NSC lattice model capturing these interactions demonstrate that they are linked by lineage progression and control the spatiotemporal distribution of output neurons. These results highlight how local and temporally delayed interactions occurring between brain germinal cells generate self-propagating dynamics that maintain NSC population homeostasis with specific spatiotemporal correlations.

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“…Таким образом, репаративный потенциал кожи определяет характер ее морфофункциональных преобразований, косметический результат раневых процессов [57,79]. Концептуальный подход к пониманию молекулярных механизмов нейроиммуноэндокринной регуляции физиологических и патофизиологических процессов в коже [81,85,91,92,93,95] позволит расширить возможности управляемой регенерации в случае повреждения кожи, объективного контроля за течением репаративных процессов в ней.…”

Section: заключениеunclassified

Neuroimmunoendocrine Regulation of the Skin Functioning

et al. 2019

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The review deals with modern ideas of neuroimmunoendocrine regulation of physiological and pathophysiological processes in skin. The present data are provided which indicate to composite mechanisms of intercellular interactions in complex regulating systems (nervous, immune, endocrine) acting at the level of skin in normal conditions, as well during the posttraumatic period. We describe different modes for participation of endocrine and nervous systems in immunologically induced skin inflammation. The data are provided confirming localization of adrenergic receptors on membranes of immunocompetent cells and leukocytes, on regulatory effects of hypothalamus upon immune functions, about multidirectional actions upon inflammation of sympathetic and parasympathetic nervous system etc.There are sufficient data on promotion of pathophysiological changes and reconstitution processes in the skin due to effects of local immune cells and bioactive substances expressed by them. The course of skin wound regeneration depend on the type of damage, degree and a phase of healing process. Posttraumatic reparative potential of skin is often limited by the infectious processes initiated by local microflora, products of cell disintegration and necrotic tissues. The cause-effect relationship is proven by arising inflammation which is implemented by inclusion of immune protection responses. The increased necrotic area and suppuration of the wound occurs die to inhibition of system of the phagocytizing macrophages. However, activation of this system brings about formation of the connective tissue capsule around the inflammation focus within early terms.We also discuss the issues of reparative skin regeneration which of great medico-social value, in connection with considerable prevalence of traumatic events and their social consequences, followed by expressed cosmetic defects. Evolving neurocognitive problems lead to decreased quality of the patient’s life, development of social disadaptation and further deprivation. The role of nervous system and psychological frustration in genesis of skin manifestations requires future development of the modern scientific direction, i.e., psychodermatology.Understanding of molecular mechanisms regulating the neuroimmunocutaneous interactions offers new prospectives in treatment of some skin diseases, as well as activation of the damaged skin recovery. According to the data presented in the review article, one may conclude on relevance of further studies on reparative potential of skin under interactions of homeostatic regulatory systems.

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Homeostasis, regeneration and tumour formation in the mammalian epidermis

Cited by 39 publications

References 107 publications

Stem cell dynamics, migration and plasticity during wound healing

Stem cell dynamics, migration and plasticity during wound healing

Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

Neuroimmunoendocrine Regulation of the Skin Functioning

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